sdü tıp fak derg

Medical Journal of Süleyman Demirel University

2602-2109

Süleyman Demirel Üniversitesi

10.17343/sdutfd.1482851

Brain and Nerve Surgery (Neurosurgery)

Beyin ve Sinir Cerrahisi (Nöroşirurji)

Inflammation and Apoptosis-Related Damage in Lung, Liver, and Kidney Tissues due to Subarachnoidal Hemorrhage

https://orcid.org/0000-0002-1735-4062

Oğuzoğlu

Ali Serdar

Süleyman Demirel Üniversitesi Tıp Fakültesi

https://orcid.org/0000-0002-1545-035X

Aşçı

Halil

SÜLEYMAN DEMİREL ÜNİVERSİTESİ

https://orcid.org/0009-0005-7279-0026

Canan

Musa

SÜLEYMAN DEMİREL ÜNİVERSİTESİ

https://orcid.org/0000-0002-1714-3150

Şenol

Nilgün

SÜLEYMAN DEMİREL ÜNİVERSİTESİ

https://orcid.org/0000-0002-1835-1082

Özmen

Özlem

BURDUR MEHMET AKİF ERSOY ÜNİVERSİTESİ

12 26 2024

31 4 310 317 05 20 2024 09 19 2024

1994

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Objective: Oxidant and inflammatory substances released into the blood due to subarachnoidal hemorrhage (SAH) can pass into the peripheral compartment, causing distant organ damage due to blood-brain barrier permeability caused by oxidative stress, inflammation, and apoptosis. This study aimed to demonstrate the secondary damage to peripheral organs, including the lung, kidney, and liver, resulting from SAH.Material and Method: Twenty rats were divided into sham and SAH groups, each consisting of ten animals. In the SAH group animals, 0.3 mL autologous blood taken from the tail artery was injected into the cisterna magna for 2 minutes. Seven days after SAH formation, all animals were euthanized under anesthesia. Following decapitation, brain tissues, lung, liver, and kidney tissues were placed in 10% formaldehyde for histopathological and immunohistochemical analysis.Results: In the SAH group, neuronal degeneration in the cerebral cortex, and hyperemia and hemorrhage in the lung, kidney, and liver were observed histopathologically. In immunohistochemical examinations, decreased expression of brain-derived neurotrophic factor (BDNF) and neurofilament (NF) in the cerebral cortex, cerebellum, and hippocampus sections; In lung tissues, enhanced caspase (Cas)-3, hypoxia-inducible factor 1 alpha (Hif-1α) and nuclear factor kappa beta (NF-κB) expressions in the lung, Cas-5, cyclooxygenase-1 (Cox-1) and interleukin (IL)-1 expressions in the liver, Cas-3, Cox-1 and IL-3 expressions in the kidney were observed.Conclusion: Following SAH, in addition to damage to brain tissue, peripheral tissues such as the lung, kidney, and liver can also be damaged through inflammation and apoptosis.

Subarachnoid hemorrhage Liver Lung Kidney inflammation apoptosis

This study was supported by the Suleyman Demirel University Scientific Research Projects Coordination Unit (Project code: TSG-2022-8783).

TSG-2022-8783

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