sdü tıp fak derg

Medical Journal of Süleyman Demirel University

2602-2109

Süleyman Demirel Üniversitesi

10.17343/sdutfd.1614378

Cell Metabolism Gene Expression Neurogenetics

Hücre Metabolizması Gen İfadesi Nörogenetik

Effect of Ascorbic Acid on SH-SY5Y Cells at Different pH Levels

https://orcid.org/0000-0001-7935-5004

Sancer

Okan

SÜLEYMAN DEMİREL ÜNİVERSİTESİ

https://orcid.org/0000-0003-2602-5145

Aslan Koşar

Pınar

SULEYMAN DEMIREL UNIVERSITY

03 27 2025

32 1 89 94 01 06 2025 03 23 2025

1994

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Objective: Cancer is a complex disease, and many different methods are used to treat it. Ascorbic acid is one of the nutritional supplements used to prevent the proliferation of cancer cells. Therefore, the effect of ascorbic acid at different pH levels on SH-SY5Y cells was investigated. Material and Method: The cytotoxic effect of ascorbic acid at different pH levels and concentrations, and its effect on cell proliferation and gene expression were studied on SH-SY5Y cells.Results: The pH and ascorbic acid levels that decreased the viability of the SH-SY5Y cell line and inhibited migration in wound healing were pH:8 and IC50:4.15. In addition, it was determined that p53 expression level increased (p

Ascorbic acid Migration pH Proliferation Viability

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