sdü tıp fak derg

Medical Journal of Süleyman Demirel University

2602-2109

Süleyman Demirel Üniversitesi

10.17343/sdutfd.1629663

Health Services and Systems (Other)

Sağlık Hizmetleri ve Sistemleri (Diğer)

Neuroprotective Effects of Dexpanthenol Against Chest Trauma-Induced Brain Injury in Rats

https://orcid.org/0000-0002-1469-3464

Taşan

Şerife

MEHMET AKIF ERSOY UNIVERSITY

https://orcid.org/0000-0002-1283-2096

Aşcı

Sanem

Private Meddem Hospital

https://orcid.org/0000-0002-1545-035X

Aşçı

Halil

Department of Pharmacology, Faculty of Medicine, Süleyman Demirel University

09 09 2025

32 3 184 190 01 30 2025 06 11 2025

1994

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Objective: Chest trauma-induced brain injury (CTB) occurs as a result of the formation of inflammatory markers in the lung and blood. Vitamin B5, derived from dexpanthenol (DEX), has antioxidant, anti-inflammatory, and antiapoptotic properties. This study aimed to investigate the protective effects of DXP on CTB.Materials and methods: Forty Wistar Albino males were divided into four groups as sham, CTB (Dropping a 200g weight from a height of 1 meter onto the anterior chest wall), CTB+DXP (500mg/kg, ip), and DXP. After 48 hours, rats were sacrificed under anesthesia, and the brain tissues were put into 10% formaldehyde solution for histopathological and immunohistochemical examination.Results: In the CTB group, rats exhibited significant hemorrhage, increased TNF-α, Cas-3, and decreased MBP expressions in the brain compared to the control group. DXP treatment significantly reducted hemorrhage areas and reversed immunoexpressions. Conclusion: CTB may develop in brain tissue by causing inflammation, apoptosis, and myelin sheath damage. These adverse effects can be reversed with DXP treatment.

acute cheast trauma brain dexpanthenol inflammation apoptosis

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