sdü tıp fak derg

Medical Journal of Süleyman Demirel University

2602-2109

Süleyman Demirel Üniversitesi

Behçet hastalığı patogenezindeki yenilikler

Yıldırım

Mehmet

Kılınç

Yıldız

Ceyhan

Ali

09 30 2009

16 3 29 34 11 06 2009

1994

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Behçet hastalığı tekrarlayan oro-genital ülserler, üveit, deri ve mukoza bulguları, eklem, nörolojik, ürogenital, vasküler, intestinal ve pulmoner tutulum ile karakterize olabilen sistemik bir vaskülittir. Günümüze kadar etyolojinin aydınlatılmasına yönelik çok sayıda çalışma yapılmış olmasına rağmen, hastalığın patogenezi halen kesin olarak bilinmemektedir. Bu makalede Behçet hastalığının patogenezindeki yenilikler literatür ışığında gözden geçirilmiştir. Anahtar kelimeler: Behçet hastalığı, etyopatogenez, AbstractNew advances in the pathogenesis of Behçet's diseaseBehçet's disease is a systemic vasculitis characterized by recurrent oral and genital ulcers, relapsing uveitis, mucocutaneous, articular, neurologic, urogenital, vascular, intestinal and pulmonary manifestations. Although several etiological factors have been investigated in detail for several years, the exact pathogenesis of Behçet's disease is still unknown. In this article, new advances in the pathogenesis of Behçet's disease were reviewed in the light of the literature.Keywords: Behçet's disease, etiopathogenesis,

Behçet hastalýðý etyopatogenez

Evereklioglu C. Current concepts in the etiology and treatment of Behcet disease. Surv Ophthalmol 2005;50:297-350.

Onder M, Gurer MA. The multiple faces of Behcet's disease and its aetiological factors. J Eur Acad Dermatol Venereol 2001;15:126-36.

Ghate JV, Jorizzo JL. Behcet's disease and complex aphthosis. J Am Acad Dermatol 1999;40:1-18.

Yurdakul S, Tüzün Y, Mat MC, Özyazgan Y, Yazýcý H. Behçet sendromu. In: Tüzün Y, Kotoðyan A, Aydemir EH, Baransü O, (eds). Dermatoloji. 2. Baský. Ýstanbul, Nobel Týp Kitapevleri, 1994; 393-9.

Arca E, Gür AR. Behçet Hastalýðý. T Klin J Med Sci 2003;23:261-8.

Doðanavþargil E, Keser G. Behçet Hastalýðý. T Klin J Int Med Sci 2005;1:80-91.

Boyvat A. Behçet hastalýðýnýn etiyopatogenezi. T Klin J Dermatol 2004;1415-21.

Yurdakul S, Hamuryudan V, Yazici H. Behcet syndrome. Curr Opin Rheumatol 2004;16:38-42.

Gul A, Ozbek U, Ozturk C, Inanc M, Konice M, Ozcelik T. Coagulation factor V gene mutation increases the risk of venous thrombosis in Behcet's disease. Br J Rheumatol 1996;35:1178-80.

Pay S. Behçet hastalýðý: etiyoloji ve patogenez. T Klin J Int Med Sci 2005;1:10-8.

Reynolds N. Vasculitis in Behçet's syndrome: evidence- based review. Curr Opin Rheumatol 2008;20(3):347- 52.

Önder M, Gürer MA. Ülkemizde Behçet hastalýðý epidemiyolojisi. T Klin J Int Med Sci 2007;3:4-7.

Saylan T, Mat C, Fresko I, Melikoglu M. Behcet's disease in the Middle East. Clin Dermatol 1999;17:209- 23.

Doðanavþargil E, Keser G, Behçet hastalýðý. In: Gümüþdiþ G, Doðanavþargil E, (eds). Klinik Romatoloji, 1. Baský. Ýstanbul, Deniz matbaasý, 1999; 423-39.

Zouboulis CC. Epidemiology of Adamantiades-Behcet's disease. Ann Med Interne 1999;150:488-98.

Marshall SE. Behcet's disease. Best Pract Res Clin Rheumatol 2004;18:291-311.

Pamuk ÖN, Çakýr N. Behçet hastalýðý epidemiyolojisi. T Klin J Int Med Sci 2005;1:3-9.

Zouboulis CC, May T. Pathogenesis of Adamantiades- Behcet's disease. Adv Exp Med Biol 2003;528:161- 71.

Gul A, Inanc M, Ocal L, Aral O, Konice M. Familial aggregation of Behcet's disease in Turkey. Ann Rheum Dis 2000;59:622-5.

Lehner T. Immunopathogenesis of Behcet's disease. Ann Med Interne 1999;150:483-7.

Durrani K, Papaliodis GN. The genetics of Adamantiades-Behcet's disease. Semin Ophthalmol. 2008;23(1):73-9.

Verity DH, Wallace GR, Vaughan RW, Stanford MR. Behcet's disease: from Hippocrates to the third millennium. Br J Ophthalmol 2003;87:1175-83.

Krause I, Weinberger A. Behçet's disease. Curr Opin Rheumatol. 2008;20(1):82-7

Direskeneli H. Behcet's disease: infectious aetiology, new autoantigens, and HLA-B51. Ann Rheum Dis 2001;60:996-1002.

Zierhut M, Mizuki N, Ohno S, Inoko H, Gul A, Onoe K, Isogai E. Immunology and functional genomics of Behçets disease. Cell Mol Life Sci 2003;60:1903-22.

Hamzaoui K, Hamzaoui A, Guemira F, Bessioud M, Hazma M, Ayed K. Cytokine profile in Behçets disease patients. Scand J Rheumatol 2002;31:205-10.

Evereklioglu C, Er H, Turkoz Y, Cekmen M. Serum levels of TNF-alpha, sIL-2R, IL-6, and IL-8 are increased and associated with elevated lipid peroxidation in patients with Behcet's disease. Mediators Inflamm 2002;11:87-93.

Ilhan F, Demir T, Türkçüoðlu P, Turgut B, Demir N, Gödekmerdan A. Th1 polarization of the immune response in uveitis in Behçet's disease.Can J Ophthalmol. 2008;43(1):105-8.

Duygulu F, Evereklioglu C, Calis M, Borlu M, Cekmen M, Ascioglu O. Synovial nitric oxide concentrations are increased and correlated with serum levels in patients with active Behcet's disease: a pilot study. Clin Rheumatol 2005;24:324-30.

Evereklioglu C, Inaloz HS, Kirtak N, Doganay S, Bulbul M, Ozerol E, Er H, Ozbek E. Serum leptin concentration is increased in patients with Behcet's syndrome and is correlated with disease activity. Br J Dermatol 2002;147:331-6.

Evereklioglu C, Turkoz Y, Er H, Inaloz HS, Ozbek E, Cekmen M. Increased nitric oxide production in patients with Behcet's disease: is it a new activity marker? J Am Acad Dermatol 2002;46:50-4.

Yildirim M, Baysal V, Inaloz HS, Doguc D. The significance of serum nitric oxide levels in Behcet's disease and recurrent aphthous stomatitis. J Dermatol 2004;31:983-8.

Yilmaz G, Sizmaz S, Yilmaz ED, Duman S, Aydin P. Aqueous humor nitric oxide levels in patients with Behcet disease. Retina 2002;22:330-5.

Donmez A, Aksu K, Celik HA, Keser G, Cagirgan S, Omay SB, Inal V, Aydin HH, Tombuloglu M, Doganavsargil E. Thrombin activatable fibrinolysis inhibitor in Behcet's disease. Thromb Res 2005;115:287-92.

Aksu K, Turgan N, Oksel F, Keser G, Ozmen D, Kitapcioglu G, Gumusdis G, Bayindir O, Doganavsargil E. Hyperhomocysteinaemia in Behcet's disease. Rheumatology 2001;40:687-90.

Er H, Evereklioglu C, Cumurcu T, Turkoz Y, Ozerol E, Sahin K, Doganay S. Serum homocysteine level is increased and correlated with endothelin-1 and nitric oxide in Behcet's disease. Br J Ophthalmol 2002; 86: 653-7