sdü tıp fak derg Medical Journal of Süleyman Demirel University 2602-2109 Süleyman Demirel Üniversitesi Evcil hayvanlarda MRSA taşıyıcılığı Kireçci Ekrem 12 30 2009 16 4 45 49 01 01 2010 Copyright © 1994, Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 1994 Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Metisiline dirençli stafilokoklar (MRSA), insanlarda ve hayvanlarda son derece önemli bir patojen haline gelmiştir. Bu bakteriler ile gelişen bulaşma ya da hastalıklar sonucunda, hayvanların taşıyıcı olması direk olarak insan sağlığını tehdit etmektedir. Özellikle de veteriner hekimler, hayvan bakıcıları ve aileleri hayvanlarla yakın temas halindedirler. İnsan ve hayvanların karşılıklı olarak bu patojeni bulaştırabilmesi ile toplum kökenli metisiline dirençli stafilokoklar (TK- MRSA) geniş bir rezervuar potansiyeline ulaşmaktadır. Günümüzde TK- MRSA' lara karşı yeterli önlemin alınmamasının yanı sıra mücadelenin de zor olması nedeniyle bu bakteriler gelecekte ciddi sağlık sorunları oluşturabilecektir. Anahtar Kelimeler: Evcil hayvanlar, MRSA, TaşıyıcılıkAbstractThe Carrier of MRSA in domestic animalsThe meticilline resistant staphylococcus (MRSA) has become an extremely important pathogen in humans and animals. With these bacteria develop as a result of the infection or transmission, animals as carriers to be directly threatening to human health. In particular, veterinary doctors, animal carers and their families are into close contact with animals. The origin of communty MRSA (Co-MRSA) is a large reservoir reach because it can be mutually transmitted between human and animal. Currently, because of Co-MRSAs without taking adequate measures as well as difficulty of the measures, serious health problems related with these bacteria will further be created.Key words: Domestic animal, MRSA, Carrier

 Evcil hayvanlar MRSA Taþýyýcýlýk Çetinkaya Y, Ünal S. Metisilin dirençli Staphylococcus aureus infeksiyonlarý: epidemiyoloji ve kontrol. Flora1996;1;3 (ek):3-16. Kapuaðasý A, Aðalar C, Apaydýn N, Türkyýlmaz R. Çeþitli klinik örneklerden izole edilen stafilokok suþlarýnýn antibiyotik direnç oranlarýnýn deðerlendirilmesi. Ankara Üniversitesi Týp Fakültesi Mecmuasý 1997;50(2):105-08. Kollef MH, Micek ST. Methicillin-resistant Staphylococcus aureus: a new comunity-acquired pathogen? Current Opinion in Infectious Disease 2006;19(2):161-68. Aygün F, Hatipoðlu N, Somer A, Keser M, Tuðrul MZ, Salman N ve ark. Toplum Kökenli MRSA; Bir Olgu Sunumu. Ulusal Çocuk Enfeksiyon Hastalýklarý Kongresi Poster Bildiriler 1. Bölüm, Çocuk Enf Derg 2007;1:107-25. O’Rourke K. Methicillin-resistant Staphylococcus aureus: an emerging problem in horses? J Am Vet Med Assoc 2003;223(10):1399-01. Centers for disease control and prevention: antibiotic resistance,cdc,website (www.cdc.gov/ncidod/ dhqp/ar_MRSA_ca_clinicians.html). Bochev I, Russenova N. Resistance of staphylococcus spp. strains isolated from goats with subclinical mastitis. Bulgarian journal of veterinary medicine 2005;8(2):109- 18. Loo I, Huijsdens X, Tiemersma E, Neeling A, Sande- Bruinsma N, Beaujean D, et al. Emergence of methicillin-resistant Staphylococcus aureus of animal origin in humans. Emerg Infect Dis 1997;13(12):834- 39. Seguin JC, Walker RD, Caron JP, Kloos WE, George CG, Hollis RJ, et al. Methicillin-resistant Staphylococcus aureus outbreak in a veterinary teaching hospital: potential human-to-animal transmission. J Clin Microbiol 1999;37 (5):1459–63. Manian FA. Asymptomatic nasal carriage of mupirocin- resistant, methicillin-resistant Staphylococcus aureus (MRSA) in a pet dog associated with MRSA infection in household contacts. Clin Infect Dis 2003; 36:26–8. Duijkeren E, Wolfhagen M, Box ATA, Heck M, Wannet WJB, Fluit AC. Human-to-Dog Transmission of Methicillin-Resistant Staphylococcus aureus. Emerg Infect Dis 2004;10(12):2235-37. Gortel K, Campbell KL, Kakoma I, Whittem T, Schaeffer DJ, Weisiger RM. Methicillin resistance among staphylococci isolated from dogs. Am J Vet Res 1999;60(12):1526-30. Frank LA, Kania SA, Hnilica KA, Wilkes RP, Bemis DA. Isolation of Staphylococcus schleiferi from dogs with pyoderma. J Am Vet Med Assoc 2003;222(4):451- 54. Kawano J, Shimizu A, Saitoh Y, Yagi M, Saito T, Okamoto R. Isolation of methicillin-resistant coagulase- negative staphylococci from chickens. J Clin Microbiol. 1996;34(9):2072-77. Lee JH. Methicillin (Oxacillin)-resistant Staphylococcus aureus strains isolated from major food animals and their potential transmission to humans. Appl Environ Microbiol 2003;69(11):6489-94. Goni P, Vergara Y, Ruiz J, Albizu I, Vila J, Gomez- Lus R. Antibiotic resistance and epidemiological typing of Staphylococcus aureus strains from ovine and rabbit mastitis. Int J Antimicrob Agents 2004;23(3):268-72. Leonard FC, Abbott Y, Rossney A, Quinn PJ, O’Mahony R, Markey BK. Methicillin-resistant Staphylococcus aureus isolated from a veterinary surgeon and five dogs in one practice. Vet Rec.2006;158(5):155-59. Devriese LA, Hommez J. Epidemiology of methicillin- resistant Staphylococcus aureus in dairy herds. Res Vet Sci 1975;19:23-7. Weese JS, Rousseau J, Willey BM, Archambault M, McGeer A, Low DE. Methicillin-resistant Staphylococcus aureus in horses at a veterinary teaching hospital: frequency, characterization, and association with clinical disease. JVet Intern Med 2006;20(1):182- 86. Duquette RA, Nuttall TJ. Methicillin-resistant Staphylococcus aureus in dogs and cats: an emerging problem? J Small Anim Pract 2004;45(12):591-97. Manian FA. Asymptomatic nasal carriage of mupirocin- resistant, methicillin-resistant Staphylococcus aureus (MRSA) in a pet dog associated with MRSA infection in household contacts. Clin Infect Dis 2003;36(2):26- 8. Scott GM, Thomson R, Malone-Lee J, Ridgway GL. Crossinfection between animals and man: possible feline transmission of Staphylococcus aureus infection in humans? J Hosp Infect1988;12:29-4. Kireçci E, Çolak A. Kuru dönem baþlangýcýnda subklinik mastitisli ineklerden izole edilen stafilokok suþlarýnda metisilin direnci. Kafkas Üniv Vet Fak Derg 2002; 8(2): 98-100. Lilenbaum W, Nunes EL, Azeredo MA. Prevalence and antimicrobial susceptibility of staphylococci isolated from the skin surface of clinically normal cats. Lett Appl Microbiol 1998;27(4):224-28. Weese JS, Archambault M, Willey BM, Dick H, Hearn P, Kreiswirth BN, et al. Methicillin-resistant Staphylococcus aureus in Horses and Horse Personnel, 2000–2002. Emerg Infect Dis 2005;11(3):430-35. Kaszanyitzky EJ, Janosi S, Egyed Z, Agost G, Semjen G. Antibiotic resistance of staphylococci from humans, food and different animal species according to data of the Hungarian resistance monitoring system in 2001. Acta Vet Hung 2003;51(4):451-64. Nunes SF, Bexiga R, Cavaco LM, Vilela CL. Technial Note: Antimicrobial Susceptibility of Portuguese Isolates of Staphylococcus aureus and Staphylococcus epidermidis in Subclinical Bovine Mastitis. J Dairy Sci 2007;90:3242-46. Pak SI, Han HR, Akira S. Characterization of Methicillin-Resistant Staphylococcus aureus Isolated from Dogs in Korea. J Vet Med Sci 1999;61(9):1013–18. Moon KJS, Lee AR, Kang HM. Lee ES, Kim MN, Paik YH, et al. Phenotypic and Genetic Antibiogram of Methicillin-Resistant Staphylococci Isolated from Bovine Mastitis in Korea. J Dairy Sci 2007;90:1176- 85. Rich M, Roberts L. Methicillin-resistant Staphylococcus aureus isolates from companion animals. Vet Rec. 2004;154(10):310. Weese JS, Caldwell F, Willey BM, Kreiswirth BN, McGeer A, Rousseau J, et al. An outbreak of methicillin-resistant Staphylococcus aureus skin infections resulting from horse to human transmission in a veterinary hospital. Vet Microbiol 2006;16;114(1- 2):160-64. Neeling AJ, van den Broek MJ, Spalburg EC, van Santen-Verheuvel MG, Dam-Deisz WD, Boshuizen HC, et al. Vet Microbiol 2007;122:366–72. Voss A, Loeffen F, bakker J, Klassen C, Wulf M. Methicillin resistant Staphylococcus aureus in pig farming. Emerg Infect Dis 2005;11:1965-66. Loeffler A, Boag AK, Sung J, Lindsay JA, Guardabassi L, Dalsgaard A, et al. Prevalence of methicillin- resistant Staphylococcus aureus among staff and pets in a small animal referral hospital in the UK. J Antimicrob Chemother 2005;56:692–97. Weese JS, Dick H, Willey BM, McGeer A, Kreiswirth BN, Innis B, Low DE. Suspected transmission of methicillin-resistant Staphylococcus aureus between domestic pets and humans in veterinary clinics and in the household. Vet Microbiol 2006;115(1-3):148-55. Van Duijkeren E, Wolfhagen MJ, Box AT, Heck ME, Wannet WJ, Fluit AC. Human-to-dog transmission of methicillin-resistant Staphylococcus aureus. Emerg Infect Dis 2004;10(12):2235-37. Wulf MW, Sİrum M, van Nes A, Skov R, Melchers WJ G, Klaassen CHW, Voss A. Prevalance of methicillin-resistant Staphylococcus aureus in Veterinarians: an international study. Clin Microbial Infect 2008;14: 29-4. Wulf MW, van Nesn A, Eikelenboom-Boskamp A, de Vries J, Melchers W, Klaassen C, Voss A. Methicillin- resistant Staphylococcus aureus in Veterinary Doctors and Students, the Netherlands. Emerg Infect Dis 2006;12:1939-41. Bilgehan H.Klinik Mikrobiyolojik Taný. Ýzmir, Barýþ Yayýnlarý, 3.Basým. 2002;35-5.