sdü tıp fak derg Medical Journal of Süleyman Demirel University 2602-2109 Süleyman Demirel Üniversitesi Resveratrol ve Etkileri Üzerine Bir Gözden Geçirme Ergin Kemal Yaylalı Aslı 09 30 2013 20 3 115 120 07 20 2011 Copyright © 1994, Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 1994 Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

A review about resveratrol and it’s effectsResveratrol is a natural polyphenolic compound that found in grape, red wine, peanut, grape leaf, carob andblue berry. The first studies with resveratrol was started at 1976 by the scientists Langcake and Pryce atgrape leaves. It is known that resveratrol, that have highligted antioxidant properties and its related celldeath. Despite the French society consume foods rich of fat and cholesterol, the rate of cardiovascular diseasein French society is rather low. It is thought that this protective effect occur through intake of resveratrolin red wine and this event is called “French paradox”. Moreover, it is found that resveratrol inhibited thecellular events associated with carsinogenesis. The studies of the effects of physiological and pathologicalconditions and the possible protective effects of diseases through resveratrol stil continues. In this paper,resveratrol’s some effects in the body and some protective effect on the tissues has been taken

Resveratrol üzüm, kırmızı şarap, yer fıstığı, asma yaprağı, keçi kulağı ve yabanmersininde bulunan doğal polifenolik bir bileşiktir. Resveratrolle ilgili ilk çalışmalar 1976'da Langcake ve Pryce adlı araştırmacılar tarafından asma yaprağında başlamıştır. Antioksidan özellikleri ön plana çıkan resveratrolun lipid peroksidasyonunu ve buna bağlı hücre ölümünü önlediği bilinmektedir. Fransız toplumu yağ ve kolesterol bakımından zengin gıdalar tüketmesine rağmen kalp ve damar hastalıkları oranı Fransız toplumunda oldukça düşüktür. Bu koruyucu etkinin kırmızı şaraptaki resveratrol alımı sayesinde oluştuğu düşünülmekte ve bu durum, "Fransız Paradoksu" olarak adlandırılmaktadır. Bununla birlikte resveratrolün karsinogenezis ile ilişkili hücresel olayları inhibe ettiği bulunmuştur. Resveratrolün fizyolojik ve patolojik durumlardaki etkileri ve hastalıklardaki olası koruyucu etkileri konusunda çalışmalar halen sürmektedir. Bu yazıda resveratrolün vücuttaki etkilerinden ve dokular üzerindeki koruyucu etkilerinden bazıları ele alınmıştır.

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