sdü tıp fak derg Medical Journal of Süleyman Demirel University 2602-2109 Süleyman Demirel Üniversitesi Dentistry Diş Hekimliği The effects of high fructose corn syrup on respiratory system Yüksek oranda fruktoz içeren mısır şurubunun solunum sistemine etkisi Öztürk Önder Akkaya Ahmet Argüz Gülsüm Özmen Özlem Kavrık Oğuzhan Kaplan Şeyhmus 03 30 2015 22 1 1 7 12 17 2014 Copyright © 1994, Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 1994 Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Aim: The effects of high fructose corn syrup diet on rat lungs were examined in this study. Material and methods: Twenty-four Wistar Albino female rats were randomly divided into three groups; Group I: corn syrup diet (30% corn sugar solution for 10 weeks orally). Group 2: corn syrup diet and alpha lipoic acid (100 mg/kg, added to diet after four weeks, orally). Group III: control group. The histopathological changes in lungs were evaluated, and malondialdehyde (MDA) and catalase levels were measured in tissue homogenize samples. Among-group comparisons, ANOVA, Kruskal-Wallis, Mann Whitney-U were used; Bonferroni,Tukey and LSD tests were used for post-hoc analysis. Results: The histopathological changes (hyperemia, edema, lymphoid tissue hyperplasia and inflammatory reaction) in lungs were found statistically different between groups (p = 0.004). While the histopathological changes were increased in Group. I, they were decreased in Group II (p = 0.057). Although MDA levels were statistically different between groups (p <0.005), it was not shown between the groups’catalase levels (p> 0.05). Conclusion: It was shown that corn syrup diet caused histopathological changes in rat lungs, and ALA had an ameliorative effect on these lesions. However further studies are needed to show the mechanisms how corn syrup affects the lungs

Amaç: Bu çalışmada, yüksek oranda fruktoz içeren mısır şurubu ile beslenen sıçanlarda mısır şurubunun sıçan akciğerleri üzerindeki etkileri incelendi. Gereçler ve Yöntem: Yirmi dört adet Wistar Albino dişi rat 3 gruba ayrıldı. Grup 1: Mısır şurubu diyeti (10 hafta %30'luk, oral), Grup 2: Mısır şurubu diyeti +Alfa Lipoik Asit (ALA) (100 mg/kg, 4 haftadan sonra, oral) Grup 3: Kontrol grubu. Deney sonrasında sıçan akciğerlerindeki değişiklikler histopatolojik olarak değerlendirildi. Alınan kan örneklerinde Malondialdehit (MDA) ve Katalaz düzeyleri ölçüldü. Üç grupta elde edilen veriler; Kruskal Wallis, Mann Whitney-U ve ANAVO post hocBonferroni testleri kullanılarak karşılaştırıldı. Bulgular: Akciğer dokusunun histopatolojik (hiperemi, ödem, lenfoid doku hiperplazisi ve inflamatuvar reaksiyon) değerlendirilmesinde gruplar arasında istatistiksel olarak anlamlı fark mevcuttu (p=0.004). Histopatolojik değişiklikler özellikle Grup I'de artarken, değişikliklerin II. Grupta azaldığı tespit edildi. Grup I ile II arasında istatistiksel olarak anlamlı fark saptanmadı (p=0.057). Kan MDA düzeyleri gruplar arasında farklı olmasına (p<0,005) rağmen, Katalaz düzeylerinde gruplar arasında istatistiksel olarak anlamlı fark bulunmadı (p>0.05).Sonuç: Mısır şurubu ile beslenen sıçanlarda, mısır şurubu akciğerlerde histopatolojik değişiklere sebep olduğu ve ALA'nın akciğerde oluşan bu lezyonlar üzerinde iyileştirici bir etki gösterdiği saptanmıştır. Fakat mısır şurubunun akciğerleri hangi mekanizmayla etkilediğini gösteren ileri çalışmalara ihtiyaç duyulmaktadır.

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