sdü tıp fak derg Medical Journal of Süleyman Demirel University 2602-2109 Süleyman Demirel Üniversitesi 10.17343/sdutfd.343111 Clinical Sciences Klinik Tıp Bilimleri Probiyotik Kaynaklı, Muhtemel Prebiyotik Özelliğe Sahip Ekzopolisakkarit (EPS)’ lerin Biyolojik ve Fonksiyonel Özellikleri Biological and Functional Properties of Possible Prebiotic Properties of Exopolysaccharides (EPSs) from Probiotics Tükenmez Ümmügülsüm GAZİ ÜNİVERSİTESİ Aslım Belma GAZİ ÜNİVERSİTESİ 12 01 2018 25 4 487 497 10 12 2017 02 15 2018 Copyright © 1994, Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 1994 Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Kanser, günümüzün en önemli sağlıksorunlarından birisidir ve dünyada en çok ölüme neden olan hastalıklardanbiridir. Kanser tedavisinde kullanılan mevcut anti-kanser ilaçlar doza bağlıolarak toksisite göstermekte ve güçlü yan etkilere (enfeksiyon, saç dökülmesi,yorgunluk, dudak yaraları, mide bulantısı, kusma, diyare ve kanlı dışkılar)neden olmaktadır. Dolayısıyla kanserintedavisinde etkili ve daha az toksik olan anti-kaser ajanların geliştirilmesineihtiyaç duyulmaktadır. Laktik asitbakterileri (LAB) gibi güvenilir ve doğal kaynaklardan elde edilen ekzopolisakkarit(EPS)’lerin, sentetik anti-kanser ajanlarına göre iyi bir alternatifolabileceği düşünülmektedir. ÇeşitliEPS’lerin yararlılığı EPS’nin monosakkarit kompozisyonuna, bağların türüne,dallanma derecelerine ve molekül ağırlığına bağlı olduğu için bu derleme EPS’lerinyapısı ve biyolojik aktivitesi ve EPS’lerin anti-kanser etkileri ile ilgilibilgiler içermektedir.

Nowadays, cancer is one of the mostimportant health problems and is one of the diseases that causes the mostdeaths in the world. Existing anti-cancer drugs used in cancer treatment showtoxicity dose dependent manner and cause strong side effects (infection, hairloss, fatigue, lip sores, nausea, vomiting, diarrhea and bloody feces). Therefore, there is a need to develop anti-cancer agentsthat are effective and less toxic in the cancer treatment. Exopolysaccharides (EPSs)obtained from safe and natural sources, such as lactic acid bacteria (LAB), arethought to be a good alternative to synthetic anti-cancer agents. Theusefulness of the various EPSs is due to the fact that the EPS is dependent onthe monosaccharide composition, the ties of the bonds, the branching degreesand the molecular weight, this review contains information on the structure andbiological activity of EPSs and the mechanism of anti-cancer action of EPSs.

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