sdü tıp fak derg Medical Journal of Süleyman Demirel University 2602-2109 Süleyman Demirel Üniversitesi 10.17343/sdutfd.345988 Clinical Sciences Klinik Tıp Bilimleri Kanserde MikroRNA’lar ve İlaç Yanıtı Aydın Acar Çiğdem MEHMET AKİF ERSOY ÜNİVERSİTESİ Yeşilot Şükriye MEHMET AKİF ERSOY ÜNİVERSİTESİ 12 01 2018 25 4 498 507 10 23 2017 01 22 2018 Copyright © 1994, Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 1994 Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

MikroRNA’lar(miRNA), hedef gen ekspresyonunu post-transkripsiyonel olarak kontrol edenküçük kodlanmayan RNA molekülleridir. miRNA’ların hedef genleri baskılayarakbüyüme, gelişme, farklılaşma ve hücre ölümü süreçlerinin düzenlenmesinde önemlirol oynadığına dair çok sayıda çalışma mevcuttur. MiRNA’ların düzenlenmesindekibozuklukların kanser ile bağlantılı olması bu bağlamda şaşırtıcı değildir. Bunaek olarak, miRNAifadelerinin ilaçlar tarafından değiştirilebildiği ve miRNA'ların kansertedavisinde ilaç metabolizmasının düzenlenmesini ve toksisiteyi etkilediğibildirilmiştir. İlaç yanıtı, hemgenetik hem de çevresel faktörler tarafından düzenlenen karmaşık bir süreçtir.Bugüne kadar farklı miRNA'ların birçok antikanser terapiye karşı duyarlılığıöngördüğü veya etkilediği bulunmuştur. Bu derleme de, miRNA biyojenezini takiben,miRNA'ların kanser, ilaç yanıtı ve antikanser tedavileri üzerindeki potansiyelrolünü ortaya koyan mevcut çalışmaların tartışılması amaçlanmıştır.

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