sdü tıp fak derg

Medical Journal of Süleyman Demirel University

2602-2109

Süleyman Demirel Üniversitesi

Clinical Sciences

Klinik Tıp Bilimleri

Biyolojik damarsal greft üretiminde hücresizleştirme metodları; güncel literatür derlemesi

Çeviker

Kadir

Özcan Özseven

Semanur

Şeker

Cennet Gülnihal

Rahim

Monira

Kılıçarslan

Şeyma

Yakzan

Rasih

03 15 2017

24 1 12 23 10 25 2016 12 27 2016

1994

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Hücresizleştirme (Decellularization) hücre ve hücre içi organellerin zarlarınınbütünlüğünü bozarak DNA, RNA, yağlar, mitokondri ve sitoplazmik zardaki hücrekimliğini taşıyan proteinler ve sitozolik içerik gibi tüm hücresel yapıların temizlenerek,önemli hücre dışı matriks yapılarının üç boyutlu ultrastrüktür, temel matriks proteinlerive büyüme faktörleri gibi öğelerinin korunması ve sonrasında implantasyon ilein vivo ya da in vitro ortamda dokunun kendine ait özelliklerle başarılı bir şekildeyeniden modellenmesi işlemidir. Bu derleme makalesinin amacı damar dokusununhücresizleştirilmesi işlemi sırasında kullanılan birçok farklı çeşit yöntemin incelenerekbaşarılı veya başarısız yönlerinin ortaya konmasıdır.

Hücresizleştirme doku yapay organ

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