sdü tıp fak derg

Medical Journal of Süleyman Demirel University

2602-2109

Süleyman Demirel Üniversitesi

10.17343/sdutfd.422561

Health Care Administration

Sağlık Kurumları Yönetimi

FASTING SERUM GHRELIN LEVELS IS NEGATIVELY ASSOCIATED WITH BODY MASS INDEX, CHOLESTEROL, TRIGLYCERIDE AND C-REACTIVE PROTEIN

AÇLIK SERUM GRELİN DÜZEYLERİ VÜCUT KİTLE İNDEKSİ, KOLESTEROL, TRİGLİSERİT VE C- REAKTİF PROTEİN İLE NEGATİF İLİŞKİLİDİR

Cebeci

Defne

Evgen Tülüceoğlu

Eda

Gonca

Taner

Şahin Calapoğlu

Nilüfer

Öztürk

Önder

https://orcid.org/0000-0002-6539-1335

Calapoğlu

Mustafa

06 01 2019

26 2 141 149 05 10 2018 11 06 2018

1994

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Objective The aim of this study is to evaluate the relationship of ghrelin hormone with body mass index (BMI) in cohort of adult men and women subsequently categorized from normal weight to morbidly obese based on BMI criteria. The relationship among the total ghrelin, serum lipids and C-reactive protein (CRP) was also evaluated. Materials and Methods Two-hundred sixty men (n=151) and women (n=109) between the ages of 20 and 59 years were recruited from Sleep Disorder Center of Medicine Faculty of Süleyman Demirel University and of Isparta Gülkent State Hospital. Fasting plasma total ghrelin, CRP, serum lipids and glucose levels were measured after overnight fasting.ResultsGhrelin levels were found to be statistically significantly lower in obese subjects (P<0.001), Glucoselevels were clinically higher in obese subjects but notstatistically significant. Fasting plasma ghrelin wasnegatively correlated with BMI, cholesterol, triglyceride (TG) and CRP (r=-0,402, P<0,01; r=0,259, p=0,01;r=0,137, p=0,05; r=0,146, p=0,05), respectively). There was weak significant correlation between ghrelinand glucose (r=0,131, p=0,05).ConclusionObese subjects have low fasting ghrelin levels thatthey are significantly related to glucose, CRP, Cholesterol, triglyceride and body mass index. More prospective studies are needed to establish the role of ghrelin in the pathogenesis of human obesity.

Amaç: Bu çalışmanın amacı, vücut kitle indeksi (VKİ)kriterlerine göre normal ağırlıktan morbid obeze kadar gruplandırılan erişkinerkek ve kadın kohortunda grelin hormonunun VKİ, serum lipitleri ve C-reaktifprotein (CRP) ile ilişkisini değerlendirmektir. Gereçve Yöntem: Isparta GülkentDevlet Hastanesi Göğüs Hastalıkları Uyku Laboratuarıve Süleyman DemirelÜniversitesi Tıp Fakültesi Uyku Hastalıkları Merkezine başvuran 20-59 yaş arasıtoplam iki yüz altmış erkek (n = 151) ve kadın (n = 109) çalışmaya dahiledildi. Toplam grelin, CRP, serum lipitleri ve glukoz seviyeleri geceaçlığından sonra ölçüldü. Bulgular: Grelin düzeyleri obez olgularda istatistikselolarak anlamlı derecede düşük bulundu (P <0.001), Glikoz düzeyleri obezolgularda klinik olarak daha yüksekti ancak istatistiksel olarak anlamlıdeğildi. Açlık plazma grelin, VKİ, kolesterol, trigliserid ve CRP ile negatifkorelasyonlar gösterdi (sırasıyla, r = -0.402, P <0.01; 0,259, p = 0,01;0,137, p = 0,05; r = 0,146, p = 0,05). Grelin ve glukoz arasında zayıf anlamlıkorelasyon vardı (r = 0,131, p = 0,05). Sonuç: Obez bireylerin grelin düzeylerinin düşük olmasıglikoz, CRP, kolesterol, trigliserid ve vücut kitle indeksi ile anlamlıderecede ilişkilidir. Grelinin insan obezitesinin patogenezindeki rolünübelirlemek için daha ileriye dönük çalışmalara ihtiyaç vardır.

Obezite Serum lipidleri İnflamasyon Yetişkin Grelin

Obesity Serum lipids Inflammation Adults Ghrelin

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