sdü tıp fak derg Medical Journal of Süleyman Demirel University 2602-2109 Süleyman Demirel Üniversitesi 10.17343/sdutfd.507410 Clinical Sciences Klinik Tıp Bilimleri Isparta ve çevresinde klopidogrel direncinin araştırılması https://orcid.org/0000-0002-6480-4935 Aksoy Fatih SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİ https://orcid.org/0000-0001-7110-3443 Baş Hasan Aydın ISPARTA ŞEHİR HASTANESİ https://orcid.org/0000-0002-8792-6329 Bağcı Ali ISPARTA ŞEHİR HASTANESİ Uysal Bayram Ali SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİ Aksoy Seda AFYONKARAHİSAR DİNAR DEVLET HASTANESİ Varol Ercan SULEYMAN DEMIREL UNIVERSITY, FACULTY OF MEDICINE, MEDICINE PR. Altınbaş Ahmet SULEYMAN DEMIREL UNIVERSITY, FACULTY OF MEDICINE, MEDICINE PR. 12 01 2019 26 4 416 422 01 03 2019 02 14 2019 Copyright © 1994, Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 1994 Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Giriş ve amaç: Akut koroner sendrom (AKS) ile başvuran ve/veyastent uygulanan hastalarda klopidogrel tedavisi günümüzde standart tedavidir.Bununla beraber klopidogrel tedavisine yanıtsızlık olumsuz sonuçlarla ilişkiliolması nedeni ile günümüzde önemli bir sorundur. Antitrombositer ilaçlarınetkinliğini ölçmek için kullanılan trombosit fonksiyon testleri çoğu kezpahalı, zaman alıcı ve ulaşılması zor testlerdir. Klopidogrel direncinisaptamak için pratik, kolay uygulanabilinir, ucuz ve güvenilir parametrelereihtiyaç vardır. Materyal-Metot: Akut Koroner Sendrom tanısı ile klopidogrelkullanan 531 hasta çalışmaya alındı. Alınan kan örneklerinde MEA (multipleelectrod aggregometry) ile çalışıldı. Sonuçlar eğri altında kalan alan (AUC)cinsiden verildi. AUC > 470 olması klopidogrel direci, olarak yorumlandı. Bulgular: Toplamda65 (% 12,2) hastada klopidogrel direnci saptandı. Kadınhastalarda klopidogrel direnci anlamlı olarak fazlaydı (P= 0,005). Riskfaktörlerine bakıldığında ise hiperlipidemik ve diyabetik hastalardaklopidogrel direnci daha fazla görülürken, sigara içenlerde direnç daha azgörülmekteydi (p= 0,016, p< 0,001, p= 0,046). Klopidogrel direnci olanhastalarda kalsiyum seviyesi, trombosit sayısı ve vücut kitle indeksi dahayüksek bulundu. Sonuç: Bu çalışma, vücut kitle indeksi, diyabet, hiperlipidemi,kadın cinsiyet’in klopidogrel direnci açısından bir risk faktörü olabileceğiniortaya koymuştur.

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