sdü tıp fak derg

Medical Journal of Süleyman Demirel University

2602-2109

Süleyman Demirel Üniversitesi

10.17343/sdutfd.650471

Clinical Sciences

Klinik Tıp Bilimleri

Türk kadınlarında MDR1 (ABCB1) geni C3435T, C1236T, G2677T/A, A2956G polimorfizmleri ile meme kanseri riski arasındaki ilişki

Association between MDR 1 (ABCB1) gene C3435T, C1236T, G2677T/A, A2956G polymorphisms and the risk of breast cancer among Turkish Women

Mutlu İçduygu

Fadime

Giresun University Şamlı

Hale

Evrensel

Türkkan

Özgöz

Asuman

Hekimler Öztürk

Kuyaş

Canhoroz

Mustafa

Deligönül

Adem

İmirzalıoğlu

Necat

09 01 2020

27 3 345 352 11 24 2019 01 21 2020

1994

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Amaç:Meme kanseri dünya genelinde kadınlarda en yaygın rastlanan kanser türüdür.Farklı populasyonlarda yapılan daha önceki çalışmalarda MDR1 geni polimorfizmleriile kadınlarda meme kanseri riski arasında ilişki olduğu öne sürülmüştür.Mevcut çalışmanın amacı Türk kadınlarında MDR1 geni C3435T, G2677A/T, C1236T,A2956G polimorfizmleri ile meme kanseri riski arasındaki ilişkiyiaraştırmaktır.Yöntem: Buçalışmaya 35 meme kanseri hastası ve 20 sağlıklı kontrol dahil edilmiştir. MDR1genotiplerinin belirlenmesi amacıyla polimeraz zincir reaksiyonu/restriksiyonuzunluk polimorfizmi (PCR/RFLP) yöntemi kullanılmıştır.Bulgular: Olguve kontrol grubu arasında C3435T polimorfizminin genotipleri açısından anlamlıbir fark gözlenmiştir (olgu grubu, CC %37.1, CT %28.6 ve TT %34.3; kontrolgrubu CC %25, CT %65, TT %10, p: 0.023). Diğer taraftan, C1236T ve G2677A/Tpolimorfizmlerinin genotip ve allel sıklıkları gruplar arasında farklıbulunmamıştır. A2956G polimorfizmi için ise tüm çalışma grubunun AA genotipinitaşıdığı belirlenmiştir.Sonuç:Çalışmamızda değerlendirilen hasta sayısı az olmakla birlikte, elde ettiğimizveriler MDR1 geni C3435T polimorfizminin Türk kadınlarında meme kanseri riskiniartırabileceğini düşündürmektedir.

Objective: The mostcommon malignancy in women is breast cancer worldwide. Previous studiesperformed in different populations have suggested an association betweenMulti-Drug Resistance (MDR1) gene polymorphisms and breast cancer risk inwomen. The purpose of the current study is to examine relationship between MDR1polymorphisms (C3435T, G2677T/A, C1236T, A2956G) and the risk of breast cancerin Turkish women.Methods: In this study35 breast cancer cases and 20 healthy controls were enrolled. Identificationof MDR1 genotypes was performed with the polymerase chain reaction/restrictionfragment length polymorphism (PCR-RFLP) technique.Results: We observedsignificant difference in distribution of C3435T genotypes between the casesand the controls (cases, CC 37.1%, CT 28.6%, and TT 34.3%; controls, CC 25%, CT65%, and TT 10%, p: 0.023). On the other hand, no significant differences ingenotype and allele frequencies of C1236T and G2677T/A polymorphisms wereobserved between groups. We also found that all subjects carry AA genotype forA2956G polymorphism.Conclusion: Although our study group is small, the results suggest that the MDR1C3435T polymorphism may increase the breast cancer risk in Turkish women.

Breast cancer MDR1 gene Polymorphism

Meme kanseri MDR1 geni Polimorfizm

Research Projects Committee of Afyon Kocatepe University

Project Number: BAP08.TIP.13

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