sdü tıp fak derg

Medical Journal of Süleyman Demirel University

2602-2109

Süleyman Demirel Üniversitesi

10.17343/sdutfd.887724

Clinical Sciences

Klinik Tıp Bilimleri

DOES EXCESSIVE CONSUMPTION OF FLAXSEED (LINUM USITATISSIMUM L.) CAUSE A LIVER DAMAGE IN RAT MODELS?

AŞIRI DOZ KETEN TOHUMU (LINUM USITATISSIMUM L.) TÜKETİMİ RATLARDA KARACİĞER HASARINA NEDEN OLUR MU?

https://orcid.org/0000-0003-3190-4486

Özgöçmen

Meltem

SULEYMAN DEMIREL UNIVERSITY, .

https://orcid.org/0000-0003-3354-8489

Yeşilot

Şükriye

MEHMET AKIF ERSOY UNIVERSITY

06 15 2021

28 2 333 341 02 27 2021 08 03 2021

1994

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Natural health products and functional foods arefrequently consumed for the prevention and treatmentof many diseases. Flaxseed is one of the functional foods with anticancer, antiviral, antibacterial and antifungalproperties. In addition to its beneficial effects,excessive consumption without considering the appropriatedosage can cause toxic effects. In this study,it was planned to investigate the effects of differentamounts of flaxseed consumption on rat liver.Materials and MethodsRats were randomly divided into four groups with 8rats in each groups; control group and experimentalgroups which given flaxseed for 7 days; 1.4, 2.8 and5.6 g/kg/day, respectively. At the end of the experiment,histological, immunohistochemical and biochemicalanalyzes were performed on tissue and bloodsamples.ResultsSerum AST, ALT and ALP values are significantly higherin 5.6 g/kg of flaxseed compared to control group(p values 0.003, 0.012 and 0.009, respectively). Albuminvalues were significantly lower in experimentalgroups compared to the control group (p

Doğal sağlık ürünleri ve fonksiyonel gıdalar, birçokhastalığın önlenmesi ve tedavisi için tüketilmektedir.Keten tohumu antikanser, antiviral, antibakteriyel veantifungal özelliklere sahip fonksiyonel gıdalardan biridir.Yararlı etkilerinin yanı sıra bilinçsiz ve aşırı tüketilmesitoksik etkilere neden olabilmektedir. Bu çalışmada,farklı miktarlarda keten tohumu tüketimininsıçan karaciğeri üzerindeki etkilerinin araştırılmasıplanlanmıştır.Gereç ve YöntemSıçanlar; her grupta 8 adet olarak; kontrol grubu ve7 gün süreyle sırasıyla; 1.4, 2.8 ve 5.6 g/kg/gün ketentohumu verilen deney grupları şeklinde dört grubaayrılmıştır. Deney sonunda doku ve kan örneklerindehistolojik, immünohistokimyasal ve biyokimyasal analizleryapılmıştır.BulgularSerum AST, ALT ve ALP değerleri 5,6 g/kg keten tohumuverilen grupta kontrol grubuna göre anlamlıolarak daha yüksek gözlendi (p değerleri 0.003,0.012 ve 0.009). Albümin değerleri deney gruplarındakontrol grubuna göre anlamlı olarak düşük gözlendi(p

Flaxseed toxicity Liver Toxicity Rat

Keten tohumu toksisitesi Karaciğer toksisitesi Sıçan

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