sdü tıp fak derg

Medical Journal of Süleyman Demirel University

2602-2109

Süleyman Demirel Üniversitesi

10.17343/sdutfd.891528

Clinical Sciences

Klinik Tıp Bilimleri

KAN DOLAŞIMI ENFEKSİYONLARININ ERKEN TANISINDA İNFLAMATUVAR BELİRTEÇLERİN DEĞERLENDİRİLMESİ

EVALUATION OF INFLAMMATORY MARKERS IN THE EARLY DIAGNOSIS OF BLOODSTREAM INFECTIONS

https://orcid.org/0000-0001-5304-1007

Şirin

Fevziye Burcu

SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİ

https://orcid.org/0000-0002-7349-3438

Şirin

Mümtaz Cem

SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİ

06 15 2021

28 2 291 299 03 12 2021 04 21 2021

1994

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

AmaçBu çalışmanın amacı, kan dolaşımı enfeksiyonu(KDE)'nun tanısında kan kültürüne alternatif olarakkullanılabilecek prokalsitonin (PCT), yüksek sensitifC-reaktif protein (hsCRP), hsCRP/albümin oranı(CAR) ve tam kan sayımı (TKS) parametrelerinin tanısalperformansını araştırmaktır.Gereç ve YöntemMayıs 2019-Mayıs 2020 tarihleri arasında hastanemizdeyatarak tedavi gören ve kan kültürü, PCT,hsCRP, TKS ve albümin tetkikleri eşzamanlı istenilenhastaların dosyaları retrospektif olarak incelendi.Hastalar kan kültüründe üremesi olanlar (n=95) vekan kültüründe üremesi olmayanlar (n=157) olarak ikigruba ayrıldı. Kan kültürleri, BacT/ALERT 3D (bioMérieux,Fransa) otomatize kan kültürü sisteminde takipedildi. Prokalsitonin ve hsCRP düzeyleri, Roche Cobas6000 modüler sisteminde (Roche Diagnostics, Almanya)ölçüldü. Tam kan sayımı analizi, UniCel DxH800 hematoloji analizöründe (Beckman Coulter, ABD)gerçekleştirildi.BulgularHemokültür pozitif ve hemokültür negatif grup arasında,PCT, hsCRP, CAR, nötrofil, lenfosit, hemoglobin,eritrosit dağılım genişliği (RDW), ortalama trombosithacmi (MPV), nötrofil/lenfosit oranı (NLR), lenfosit/monosit oranı (LMR), trombosit/lenfosit oranı (PLR),MPV/trombosit oranı (MPV/PLT) ve albümin düzeyleribakımından istatistiksel olarak anlamlı fark bulundu(p

ObjectiveThe aim of this study was to investigate the diagnosticperformance of procalcitonin (PCT), high sensitive C-reactive protein (hsCRP), hsCRP/albumin ratio(CAR) and complete blood count (CBC) parameterswhich can be used as an alternative to the blood culturein the diagnosis of bloodstream infection (BSI).Materials and MethodsMedical records of the patients who received inpatienttreatment in our hospital between May 2019-May 2020and who were simultaneously requested for blood culture,PCT, hsCRP, CBC and albumin tests were retrospectivelyreviewed. The patients were divided intotwo groups as those with positive blood culture (n=95)and those with negative blood culture (n=157). Bloodcultures were performed using the BacT/ALERT 3D(bioMérieux, France) automated blood culture system.The levels of PCT and hsCRP were measuredby the Roche Cobas 6000 modular system (Roche Diagnostics,Germany). Complete blood count analysiswas performed using the UniCel DxH 800 hematologyanalyzer (Beckman Coulter, USA).ResultsA statistically significant difference was found betweenthe hemoculture positive and the hemoculture negativegroups in terms of PCT, hsCRP, CAR, neutrophil,lymphocyte, hemoglobin, red blood cell distribution width(RDW), mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR), lymphocyte/monocyte ratio(LMR) platelet/lymphocyte ratio (PLR), MPV/plateletratio (MPV/PLT) and albumin levels (p

Bakteriyemi sepsis prokalsitonin C-reaktif protein serum albümini tam kan sayımı

Bacteremia sepsis procalcitonin C-reactive protein serum albumin complete blood count.

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