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Mekonyum aspirasyon sendromu

Year 2006, Volume: 13 Issue: 1, 42 - 46, 20.04.2009

Abstract

SüleymanDemirel Üniversitesi
TIP FAKÜLTESİ DERGİSİ: 2006 Mart; 13(1)


Mekonyum aspirasyon sendromu

Hasan Çetin, Hicran Altın


Özet

Mekonyum aspirasyon sendromu (MAS), zamanında doğan yenidoğan bebekler için önemli mortalite ve morbidite sebebidir. Mekonyum aspirasyon sendromu, havayollarının tam tıkanması ile atelektazi, parsiyel tıkanması ile havalanma artışı ve ödem, kimyasal pnömoni ve sürfaktan disfonksiyonu ile karekterizedir. Persistan pulmoner hipertansiyon mekonyum aspirasyon sendromunun önemli bir komplikasyonudur. Hemodinamik bozukluklar ve fetal hipoksi, intrauterin mekonyum pasajına yol açarak, aspirasyonun doğumdan önce ya da doğum sırasında meydana gelmesine neden olur. Ağız içinde yeşil sarı renkli sekresyon, takipne, interkostal retraksiyon, siyanoz, akciğerde aşırı hava tutulumu, akciğerde raller MAS.ın klinik semptom ve bulgulardır. MAS.ın tedavisi temel olarak hava yollarının mekonyumdan temizlenmesi, sürfaktan uygulanması ve destek tedavisine dayanmaktadır.


Anahtar kelımeler: Mekonyum aspirasyon sendromu, yenidoğan, tedavi


Abstract

Meconium aspiration syndrome


Meconium aspiration syndrome (MAS) is an important cause of morbidity and mortality in full term neonates. Meconium aspiration syndrome is characterized by the atelectasis due to the complete airway obstruction, emphysema and air leak syndrome resulted from the partial obstruction of airway, chemical pneumonitis, and surfactant dysfunction. Persistent pulmonary hypertension is major complication of meconium aspiration syndrome. Haemodynamic disturbances and fetal hypoxia may lead to intrauterine meconium emission that can be aspirated by the fetus in antenatal period. Clinical signs and symptoms of MAS include yellow green secretions from the mouth, tachypnea, intercostal retraction, cyanosis, overinflated chest due to air trapping, rales in the lung. Treatment of MAS should be based on clearing the meconium from the airway, surfactant supplementation and supportive care.


Key words: Meconium aspiration syndrome, newborn, treatment.

References

  • Bhatia BD, Gupta V, Dey PK. Meconium aspiration syndrome: current consepts. Indian J Matern Child Health.1996; 7: 1-7.
  • Sriram S, Wall SN, Khoshnood B, Singht JK, Hsieh HL, Lee KS. Racial disparity in meconium stained amniotic fluid and meconium aspiration syndrome in the United States, 1989-2000. Obstet Gynecol 2003; 102: 1262-8.
  • Karatekin G, Kesim M, Nuhoðlu A. Risk factors for meconium aspiration syndrome.International Journal of GynecologyObstetrics 1999; 65: 295-297
  • Salvia-Roiges MD, Carbonell-Estrany X, Figueras- Aloy J and Rodrigues-Miguelez JM. Efficacy of three treatment schedules in severe meconium aspiration syndrome. Acta Paediatr 2004; 93: 60-65.
  • Pulmonary Diseases. In Trýcia Lacy Gomella with Cunningham MD, Eyal FG, Zenk KE.(Ed.) Neonatology, Fourth Ed, Appleton&Lange 1999; 506- 510.
  • Klinger MC, Kruse J. Meconium aspiration syndrome: pathophysioloy and prevention. J. Am Board Fam Pract 1999; 12: 450-66
  • Kaapa P. Corticosteroid treatment in meconium aspiration syndrome: a solution for better outcome?. Acta Paediatr 2004; 93: 5-7.
  • Ward M, Sinn J. Steroid therapy for meconium aspiration syndrome in newborn infants. Cochranc Databasc Syst Rev 2003; 4: 3485.
  • Ogawa Y, Shimizu H. Current strategy for manegement of meconium aspiration syndrome. Acta Paediatr Taiwan 2000; 41: 241-5.
  • Halliday HL, Speer CP, Robertson B. Treatment of severe meconium aspiarion syndrome with porcine surfactant. Eur J Pediatr 1996; 155: 1047-1051.
  • Chang HY, Hsu CH, Kao HA, Hung HY, Chang JH, Peng CC, et al Treatment of severe meconium aspiration syndrome with dilute surfactant lavage. J Formos Med Assoc 2003; 102: 326-30
  • Wiswell TE, Advances in the treatment of the meconium aspiration syndrome Acta Paediatr Suppl 2001; 90: 28-30.
  • Costa DE, Nair AK, Pai M.G, Khusaiby SM. Steroid in full term infants with respiratory failure and pulmonary hypertension due to meconium aspiration syndrome. Eur J Pediatr 2001; 160: 150-153.
  • Greenough A. Meconium aspiration syndrome- prevention and treatment Early Hum Dev 1995; 41: 183-92.
  • Oran O, Erdem G, Tekinalp G, Yurdakök M, Yiðit Þ. Persistan Pulmoner Hipertansiyon. Oran O, Erdem G, Tekinalp G, Yurdakök M, Yiðit Þ (ed). Yenidoðan bakýmýnda Hacettepe Uygulamalarý, I. Baský. Ankara: Öncü Basýmevi 2001; 39-45.
  • Calkovska A, Sun B, Curstedt T, Renheim G, Robertson B. Combined effects of high frequency ventilation and surfactant treatment in experimental meconium aspiration syndrome. Acta Anaesthesiol Scand 1999; 43: 135-145.
  • Soukka H, Halkola L, Aho H, Rautanen M, Kero P, Kaapa P. Methylprednisolone attenuates the pulmonary hypertensive response in porcine meconium aspiration. Pediatr Res 1997; 42: 145-50.
  • Kirimi E, Tuncer O, Kosem M, Ceylan E, Tas A, Tasal I et al. The effects of prednisolone and serum malondialdehyde levels in puppies with experimentally induced meconium aspiration syndrome. J. Int Res 2003; 31: 113-22.
  • Ovalý F. Mekonyum Aspirasyon Sendromu. Daðoðlu T (ed). Neonatoloji, I. Baský. Ýstanbul: Alemdar Ofset 2000; 311-316.
Year 2006, Volume: 13 Issue: 1, 42 - 46, 20.04.2009

Abstract

References

  • Bhatia BD, Gupta V, Dey PK. Meconium aspiration syndrome: current consepts. Indian J Matern Child Health.1996; 7: 1-7.
  • Sriram S, Wall SN, Khoshnood B, Singht JK, Hsieh HL, Lee KS. Racial disparity in meconium stained amniotic fluid and meconium aspiration syndrome in the United States, 1989-2000. Obstet Gynecol 2003; 102: 1262-8.
  • Karatekin G, Kesim M, Nuhoðlu A. Risk factors for meconium aspiration syndrome.International Journal of GynecologyObstetrics 1999; 65: 295-297
  • Salvia-Roiges MD, Carbonell-Estrany X, Figueras- Aloy J and Rodrigues-Miguelez JM. Efficacy of three treatment schedules in severe meconium aspiration syndrome. Acta Paediatr 2004; 93: 60-65.
  • Pulmonary Diseases. In Trýcia Lacy Gomella with Cunningham MD, Eyal FG, Zenk KE.(Ed.) Neonatology, Fourth Ed, Appleton&Lange 1999; 506- 510.
  • Klinger MC, Kruse J. Meconium aspiration syndrome: pathophysioloy and prevention. J. Am Board Fam Pract 1999; 12: 450-66
  • Kaapa P. Corticosteroid treatment in meconium aspiration syndrome: a solution for better outcome?. Acta Paediatr 2004; 93: 5-7.
  • Ward M, Sinn J. Steroid therapy for meconium aspiration syndrome in newborn infants. Cochranc Databasc Syst Rev 2003; 4: 3485.
  • Ogawa Y, Shimizu H. Current strategy for manegement of meconium aspiration syndrome. Acta Paediatr Taiwan 2000; 41: 241-5.
  • Halliday HL, Speer CP, Robertson B. Treatment of severe meconium aspiarion syndrome with porcine surfactant. Eur J Pediatr 1996; 155: 1047-1051.
  • Chang HY, Hsu CH, Kao HA, Hung HY, Chang JH, Peng CC, et al Treatment of severe meconium aspiration syndrome with dilute surfactant lavage. J Formos Med Assoc 2003; 102: 326-30
  • Wiswell TE, Advances in the treatment of the meconium aspiration syndrome Acta Paediatr Suppl 2001; 90: 28-30.
  • Costa DE, Nair AK, Pai M.G, Khusaiby SM. Steroid in full term infants with respiratory failure and pulmonary hypertension due to meconium aspiration syndrome. Eur J Pediatr 2001; 160: 150-153.
  • Greenough A. Meconium aspiration syndrome- prevention and treatment Early Hum Dev 1995; 41: 183-92.
  • Oran O, Erdem G, Tekinalp G, Yurdakök M, Yiðit Þ. Persistan Pulmoner Hipertansiyon. Oran O, Erdem G, Tekinalp G, Yurdakök M, Yiðit Þ (ed). Yenidoðan bakýmýnda Hacettepe Uygulamalarý, I. Baský. Ankara: Öncü Basýmevi 2001; 39-45.
  • Calkovska A, Sun B, Curstedt T, Renheim G, Robertson B. Combined effects of high frequency ventilation and surfactant treatment in experimental meconium aspiration syndrome. Acta Anaesthesiol Scand 1999; 43: 135-145.
  • Soukka H, Halkola L, Aho H, Rautanen M, Kero P, Kaapa P. Methylprednisolone attenuates the pulmonary hypertensive response in porcine meconium aspiration. Pediatr Res 1997; 42: 145-50.
  • Kirimi E, Tuncer O, Kosem M, Ceylan E, Tas A, Tasal I et al. The effects of prednisolone and serum malondialdehyde levels in puppies with experimentally induced meconium aspiration syndrome. J. Int Res 2003; 31: 113-22.
  • Ovalý F. Mekonyum Aspirasyon Sendromu. Daðoðlu T (ed). Neonatoloji, I. Baský. Ýstanbul: Alemdar Ofset 2000; 311-316.
There are 19 citations in total.

Details

Primary Language English
Journal Section Reviews
Authors

Hasan Çetin This is me

Hicran Altın

Publication Date April 20, 2009
Submission Date April 20, 2009
Published in Issue Year 2006 Volume: 13 Issue: 1

Cite

Vancouver Çetin H, Altın H. Mekonyum aspirasyon sendromu. Med J SDU. 2009;13(1):42-6.

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