EN
A new application of fractional glucose-insulin model and numerical solutions
Abstract
Along with the developing technology, obesity and diabetes are increasing rapidly among people. The identification of diabetes diseases, modeling, predicting their behavior, conducting simulations, studying control and treatment methods using mathematical methods has be-come of great importance. In this paper, we have obtained numerical solutions by considering the glucose-insulin fractional model. This model consists of three compartments: the blood glucose concentration (G), the blood insulin concentration (I) and the ready-to-absorb glucose concentration (D) in the small intestine. The fractional derivative is used in the sense of Caputo. By performing mathematical analyzes for the Glucose-Insulin fractional mathematical model, numerical results were obtained with the help of the Euler method and graphs were drawn.
Keywords
References
- [1] Makroglou, A., Li, J., Kuang, Y. Mathematical models and software tools for the glucose-insulin regulatory system and diabetes: an overview. Applied numerical mathematics, 2006;56(3-4):559-573.
- [2] Huard, B., Easton, J. F., Angelova, M. Investigation of stability in a two-delay model of the ultradian oscillations in glucose-insulin regulation. Communications in Nonlinear Science and Numerical Simulation, 2015;26(1-3):211-222.
- [3] Cobelli, C., Nucci, G., Del Prato, S. A physiological simulation model of the glucose-insulin system in type I diabetes. Diabetes nutrition and Metabolism, 1998; 11: 78-78.
- [4] I. Podlubny, Fractional Differential Equations, Academy Press, San Diego CA, 1999.
- [5] Bergman, R. N. The minimal model of glucose regulation: a biography. In Mathematical Modeling in Nutrition and the Health Sciences Springer, Boston, MA., 2003; (pp. 1-19).
- [6] Linda, J.S.A. An Introduction to Mathematical Biology. Pearson Education Ltd., USA, 2007; pp. 123-127.
- [7] Fabietti, P. G., Canonico, V., Federici, M. O., Benedetti, M. M., Sarti, E. Control oriented model of insulin and glucose dynamics in type 1 diabetics. Medical and Biological Engineering and Computing, 2006; 44(1):69-78.
- [8] H. Hethcote, M. Zhien, L. Shengbing. Effects of quarantine in six endemic models for infectious diseases, Mathematical Biosciences. 2002;180:141160.
Details
Primary Language
English
Subjects
Structural Biology
Journal Section
Research Article
Publication Date
April 30, 2024
Submission Date
May 25, 2022
Acceptance Date
February 8, 2023
Published in Issue
Year 2024 Volume: 42 Number: 2
APA
Öztürk, Z., Bilgil, H., & Sorgun, S. (2024). A new application of fractional glucose-insulin model and numerical solutions. Sigma Journal of Engineering and Natural Sciences, 42(2), 407-413. https://izlik.org/JA63YZ86HX
AMA
1.Öztürk Z, Bilgil H, Sorgun S. A new application of fractional glucose-insulin model and numerical solutions. SIGMA. 2024;42(2):407-413. https://izlik.org/JA63YZ86HX
Chicago
Öztürk, Zafer, Halis Bilgil, and Sezer Sorgun. 2024. “A New Application of Fractional Glucose-Insulin Model and Numerical Solutions”. Sigma Journal of Engineering and Natural Sciences 42 (2): 407-13. https://izlik.org/JA63YZ86HX.
EndNote
Öztürk Z, Bilgil H, Sorgun S (April 1, 2024) A new application of fractional glucose-insulin model and numerical solutions. Sigma Journal of Engineering and Natural Sciences 42 2 407–413.
IEEE
[1]Z. Öztürk, H. Bilgil, and S. Sorgun, “A new application of fractional glucose-insulin model and numerical solutions”, SIGMA, vol. 42, no. 2, pp. 407–413, Apr. 2024, [Online]. Available: https://izlik.org/JA63YZ86HX
ISNAD
Öztürk, Zafer - Bilgil, Halis - Sorgun, Sezer. “A New Application of Fractional Glucose-Insulin Model and Numerical Solutions”. Sigma Journal of Engineering and Natural Sciences 42/2 (April 1, 2024): 407-413. https://izlik.org/JA63YZ86HX.
JAMA
1.Öztürk Z, Bilgil H, Sorgun S. A new application of fractional glucose-insulin model and numerical solutions. SIGMA. 2024;42:407–413.
MLA
Öztürk, Zafer, et al. “A New Application of Fractional Glucose-Insulin Model and Numerical Solutions”. Sigma Journal of Engineering and Natural Sciences, vol. 42, no. 2, Apr. 2024, pp. 407-13, https://izlik.org/JA63YZ86HX.
Vancouver
1.Zafer Öztürk, Halis Bilgil, Sezer Sorgun. A new application of fractional glucose-insulin model and numerical solutions. SIGMA [Internet]. 2024 Apr. 1;42(2):407-13. Available from: https://izlik.org/JA63YZ86HX