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Yıl 2024, Cilt: 42 Sayı: 5, 1336 - 1343, 04.10.2024

Öz

Kaynakça

  • REFERENCES
  • [1] Baldock PA, Lee NJ, Driessler F, Lin S, Allison S, Stehrer B, et al. Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weight. PLoS One 2009;4:e8415. [CrossRef]
  • [2] Clarke GS, Gatford KL, Young RL, Grattan DR, Ladyman SR, Page AJ. Maternal adaptations to food intake across pregnancy: Central and peripheral mechanisms. Obesity (Silver Spring) 2021;29:18131824. [CrossRef]
  • [3] Badillo-Suárez PA, Rodríguez-Cruz M, Nieves-Morales X. Impact of metabolic hormones secreted in human breast milk on nutritional programming in childhood obesity. J Mammary Gland Biol Neoplasia 2017;22:171191. [CrossRef] [4] Upadhyay J, Farr O, Perakakis N, Ghaly W, Mantzoros C. Obesity as a disease. Med Clin North Am 2018;102:1333. [CrossRef]
  • [5] Lega IC, Lipscombe LL. Diabetes, obesity, and cancer-pathophysiology and clinical implications. Endocr Rev 2020;41:3352. [CrossRef]
  • [6] Ersoy E, Mercan Y. Risk factors for obstructive sleep apnea and the association of obstructive sleep apnea with daytime sleepiness, obesity, and comorbidity. J Turk Sleep Med 2021;8:2027. [CrossRef]
  • [7] Kauwell GP. Emerging concepts in nutrigenomics: a preview of what is to come. Nutr Clin Pract 2005;20:7587. [CrossRef]
  • [8] Blouet C, Schwartz GJ. Hypothalamic nutrient sensing in the control of energy homeostasis. Behav Brain Res 2010;209:112. [CrossRef]
  • [9] Morton G, Cummings D, Baskin D, Barsh G, Schwartz M. Central nervous system control of food intake and body weight. Nature 2006;443:289295. [CrossRef]
  • [10] Levine AS, Morley J. Neuropeptide Y: a potent inducer of consummatory behavior in rats. Peptides 1984;5:10251029. [CrossRef]
  • [11] Zarjevski N, Cusin I, Vettor R, Rohner-Jeanrenaud F, Jeanrenaud B. Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity. Endocrinology 1993;133:17531758. [CrossRef]
  • [12] Bi S, Robinson BM, Moran TH. Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression. Am J Physiol Regul Integr Comp Physiol 2003;285:R1030R1036. [CrossRef]
  • [13] Warnes K, Morris M, Symonds M, Phillips I, Clarke I, Owens J, et al. Effects of increasing gestation, cortisol and maternal undernutrition on hypothalamic neuropeptide Y expression in the sheep fetus. J Neuroendocrinol 1998;10:5157. [CrossRef]
  • [14] Plagemann A, Waas T, Harder T, Rittel F, Ziska T, Rohde W. Hypothalamic neuropeptide Y levels in weaning offspring of low-protein malnourished mother rats. Neuropeptides 2000;34:16. [CrossRef]
  • [15] Lemke H, Coutinho A, Lange H. Lamarckian inheritance by somatically acquired maternal IgG phenotypes. Trends Immunol 2004;25:180186. [CrossRef]
  • [16] Gündüz B, Stetson MH. Maternal transfer of photoperiodic information in Siberian hamsters. VI. Effects of time‐dependent 1‐hr melatonin infusions in the mother on photoperiod‐induced testicular development of her offspring. J Pineal Res 2003;34:217225. [CrossRef]
  • [17] Karakaş A, Gündüz B. Maternal transfer of photoperiodic information regulates the postnatal reproductive system development of the Mongolian Gerbil (Meriones Unguiculatus). Turk J Biol 2007;31:8793.
  • [18] Reiter R. Circannual reproductive rhythms in mammals related to photoperiod and pineal function: a review. Chronobiologia. 1974;1:365395.
  • [19] Stetson MH, Elliott JA, Menaker M. Photoperiodic regulation of hamster testis: circadian sensitivity to the effects of light. Biol Reprod 1975;13:329339. [CrossRef] [20] Czyba J. Les fluctuations de la fécondité chez le hamster doré (Mesocricetus auratus Waterhouse) au cours de l'année. Compt Rend Soc Biol 1968;162:1131136.
  • [21] McMillen IC, MacLaughlin SM, Muhlhausler BS, Gentili S, Duffield JL, Morrison JL. Developmental origins of adult health and disease: the role of periconceptional and foetal nutrition. Basic Clin Pharmacol Toxicol 2008;102:8289. [CrossRef]
  • [22] Varela L, Stutz B, Song JE, Kim JG, Liu ZW, Gao XB, et al. Hunger-promoting AgRP neurons trigger an astrocyte-mediated feed-forward autoactivation loop in mice. J Clin Invest 2021;131:e144239. [CrossRef]
  • [23] McMillen IC, Adam CL, Mühlhäusler BS. Early origins of obesity: programming the appetite regulatory system. J Physiol 2005;565:917. [CrossRef]
  • [24] Martin-Gronert MS, Ozanne SE. Maternal nutrition during pregnancy and health of the offspring. London: Portland Press Ltd; 2006. [CrossRef]
  • [25] Lim K, Zimanyi MA, Black MJ. Effect of maternal protein restriction in rats on cardiac fibrosis and capillarization in adulthood. Pediatr Res 2006;60:8387. [CrossRef]
  • [26] Coupé B, Grit I, Darmaun D, Parnet P. The timing of “catch-up growth” affects metabolism and appetite regulation in male rats born with intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol 2009;297:R813R824. [CrossRef]
  • [27] Franke K, Harder T, Aerts L, Melchior K, Fahrenkrog S, Rodekamp E, et al. Programming of orexigenic and anorexigenic hypothalamic neurons in offspring of treated and untreated diabetic mother rats. Brain Res 2005;1031:276283. [CrossRef]
  • [28] Fukami T, Sun X, Li T, Desai M, Ross MG. Mechanism of programmed obesity in intrauterine fetal growth restricted offspring: paradoxically enhanced appetite stimulation in fed and fasting states. Reprod Sci 2012;19:423430. [CrossRef]
  • [29] Qiu B, Bell RL, Cao Y, Zhang L, Stewart RB, Graves T, et al. Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight. J Genet Genomics 2016;43:421430. [CrossRef]
  • [30] Palou M, Sánchez J, Rodríguez AM, Priego T, Picó C, Palou A. Induction of NPY/AgRP orexigenic peptide expression in rat hypothalamus is an early event in fasting: relationship with circulating leptin, insulin and glucose. Cell Physiol Biochem 2009;23:115124. [CrossRef]
  • [31] Mariano IR, Yamada LA, Rabassi RS, Sabino VR, Bataglini C, Azevedo SC, et al. Differential responses of liver and hypothalamus to the nutritional condition during lactation and adult life. Front Physiol 2020;11:553. [CrossRef]
  • [32] Mercer JG, Moar KM, Logie TJ, Findlay PA, Adam CL, Morgan PJ. Seasonally inappropriate body weight induced by food restriction: effect on hypothalamic gene expression in male Siberian hamsters. Endocrinology 2001;142:41734181. [CrossRef]
  • [33] Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, et al. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 1997;278:135138. [CrossRef]
  • [34] Timper K, Brüning JC. Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity. Dis Model Mech 2017;10:679689. [CrossRef]
  • [35] Krashes MJ, Shah BP, Koda S, Lowell BB. Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP. Cell Metab 2013;18:588595. [CrossRef]
  • [36] Patton AP, Hastings MH. The suprachiasmatic nucleus. Curr Biol 2018;28:R816R822. [CrossRef]
  • [37] Haupt S, Eckstein ML, Wolf A, Zimmer RT, Wachsmuth NB, Moser O. Eat, train, sleep—retreat? Hormonal interactions of intermittent fasting, exercise and circadian rhythm. Biomolecules 2021;11:516. [CrossRef]
  • [38] Deem JD, Faber CL, Morton GJ. AgRP neurons: Regulators of feeding, energy expenditure, and behavior. FEBS J 2022;289:23622381. [CrossRef]
  • [39] Oster H, Damerow S, Kiessling S, Jakubcakova V, Abraham D, Tian J, et al. The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock. Cell Metab.2006;4:163173. [CrossRef]

Variation of NPY and AGRP MRNA expression in Syrian hamsters according to feeding times

Yıl 2024, Cilt: 42 Sayı: 5, 1336 - 1343, 04.10.2024

Öz

The purpose of this study was to determine the impact of feeding time on NPY/AgRP protein and mRNA expression in the brain during prenatal and postnatal periods. Feeding at different times of the day during pregnancy may have lasting effects on the hypothalamic circuitry in offspring energy homeostasis. In the experimental design, adult female hamsters were ran-domly assigned to receive three different feeding conditions: ad libitum, night-time feeding and day-time feeding groups. After the lactation period, feeding regimens were continued for the offspring born from mothers who were given nutritional regimens, until they were 30 days old. RT-PCR for NPY/AgRP mRNA expression and ELISA analysis for protein levels were performed on hypothalamus tissues of hamsters at 10, 20 and 30 days of postnatal stage. There was no difference between the groups in terms of the daily measured food consumption of the offspring’s. Body weights were significantly decreased in both night-time and day-time feed-ing groups compared to the ad libitum group (p<0.05). The highest increase in mRNA expres-sion of NPY/AgRP was seen in the samples taken at 10. day of lactation in the night-time and day-time feeding groups of the offspring treated with three different feeding regimens. When the feeding regimes were compared, it was observed that the protein and mRNA expression of both NPY and AGRP increased the most in the offspring groups in which the feeding was restricted night –time only. Early stages of development have shown that maternal factors have significantly affected the offspring NPY and AgRP mRNA expression and protein levels. These results show that the metabolic regulation of energy balance may change with maternal factors during the very early stages of development.

Kaynakça

  • REFERENCES
  • [1] Baldock PA, Lee NJ, Driessler F, Lin S, Allison S, Stehrer B, et al. Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weight. PLoS One 2009;4:e8415. [CrossRef]
  • [2] Clarke GS, Gatford KL, Young RL, Grattan DR, Ladyman SR, Page AJ. Maternal adaptations to food intake across pregnancy: Central and peripheral mechanisms. Obesity (Silver Spring) 2021;29:18131824. [CrossRef]
  • [3] Badillo-Suárez PA, Rodríguez-Cruz M, Nieves-Morales X. Impact of metabolic hormones secreted in human breast milk on nutritional programming in childhood obesity. J Mammary Gland Biol Neoplasia 2017;22:171191. [CrossRef] [4] Upadhyay J, Farr O, Perakakis N, Ghaly W, Mantzoros C. Obesity as a disease. Med Clin North Am 2018;102:1333. [CrossRef]
  • [5] Lega IC, Lipscombe LL. Diabetes, obesity, and cancer-pathophysiology and clinical implications. Endocr Rev 2020;41:3352. [CrossRef]
  • [6] Ersoy E, Mercan Y. Risk factors for obstructive sleep apnea and the association of obstructive sleep apnea with daytime sleepiness, obesity, and comorbidity. J Turk Sleep Med 2021;8:2027. [CrossRef]
  • [7] Kauwell GP. Emerging concepts in nutrigenomics: a preview of what is to come. Nutr Clin Pract 2005;20:7587. [CrossRef]
  • [8] Blouet C, Schwartz GJ. Hypothalamic nutrient sensing in the control of energy homeostasis. Behav Brain Res 2010;209:112. [CrossRef]
  • [9] Morton G, Cummings D, Baskin D, Barsh G, Schwartz M. Central nervous system control of food intake and body weight. Nature 2006;443:289295. [CrossRef]
  • [10] Levine AS, Morley J. Neuropeptide Y: a potent inducer of consummatory behavior in rats. Peptides 1984;5:10251029. [CrossRef]
  • [11] Zarjevski N, Cusin I, Vettor R, Rohner-Jeanrenaud F, Jeanrenaud B. Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity. Endocrinology 1993;133:17531758. [CrossRef]
  • [12] Bi S, Robinson BM, Moran TH. Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression. Am J Physiol Regul Integr Comp Physiol 2003;285:R1030R1036. [CrossRef]
  • [13] Warnes K, Morris M, Symonds M, Phillips I, Clarke I, Owens J, et al. Effects of increasing gestation, cortisol and maternal undernutrition on hypothalamic neuropeptide Y expression in the sheep fetus. J Neuroendocrinol 1998;10:5157. [CrossRef]
  • [14] Plagemann A, Waas T, Harder T, Rittel F, Ziska T, Rohde W. Hypothalamic neuropeptide Y levels in weaning offspring of low-protein malnourished mother rats. Neuropeptides 2000;34:16. [CrossRef]
  • [15] Lemke H, Coutinho A, Lange H. Lamarckian inheritance by somatically acquired maternal IgG phenotypes. Trends Immunol 2004;25:180186. [CrossRef]
  • [16] Gündüz B, Stetson MH. Maternal transfer of photoperiodic information in Siberian hamsters. VI. Effects of time‐dependent 1‐hr melatonin infusions in the mother on photoperiod‐induced testicular development of her offspring. J Pineal Res 2003;34:217225. [CrossRef]
  • [17] Karakaş A, Gündüz B. Maternal transfer of photoperiodic information regulates the postnatal reproductive system development of the Mongolian Gerbil (Meriones Unguiculatus). Turk J Biol 2007;31:8793.
  • [18] Reiter R. Circannual reproductive rhythms in mammals related to photoperiod and pineal function: a review. Chronobiologia. 1974;1:365395.
  • [19] Stetson MH, Elliott JA, Menaker M. Photoperiodic regulation of hamster testis: circadian sensitivity to the effects of light. Biol Reprod 1975;13:329339. [CrossRef] [20] Czyba J. Les fluctuations de la fécondité chez le hamster doré (Mesocricetus auratus Waterhouse) au cours de l'année. Compt Rend Soc Biol 1968;162:1131136.
  • [21] McMillen IC, MacLaughlin SM, Muhlhausler BS, Gentili S, Duffield JL, Morrison JL. Developmental origins of adult health and disease: the role of periconceptional and foetal nutrition. Basic Clin Pharmacol Toxicol 2008;102:8289. [CrossRef]
  • [22] Varela L, Stutz B, Song JE, Kim JG, Liu ZW, Gao XB, et al. Hunger-promoting AgRP neurons trigger an astrocyte-mediated feed-forward autoactivation loop in mice. J Clin Invest 2021;131:e144239. [CrossRef]
  • [23] McMillen IC, Adam CL, Mühlhäusler BS. Early origins of obesity: programming the appetite regulatory system. J Physiol 2005;565:917. [CrossRef]
  • [24] Martin-Gronert MS, Ozanne SE. Maternal nutrition during pregnancy and health of the offspring. London: Portland Press Ltd; 2006. [CrossRef]
  • [25] Lim K, Zimanyi MA, Black MJ. Effect of maternal protein restriction in rats on cardiac fibrosis and capillarization in adulthood. Pediatr Res 2006;60:8387. [CrossRef]
  • [26] Coupé B, Grit I, Darmaun D, Parnet P. The timing of “catch-up growth” affects metabolism and appetite regulation in male rats born with intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol 2009;297:R813R824. [CrossRef]
  • [27] Franke K, Harder T, Aerts L, Melchior K, Fahrenkrog S, Rodekamp E, et al. Programming of orexigenic and anorexigenic hypothalamic neurons in offspring of treated and untreated diabetic mother rats. Brain Res 2005;1031:276283. [CrossRef]
  • [28] Fukami T, Sun X, Li T, Desai M, Ross MG. Mechanism of programmed obesity in intrauterine fetal growth restricted offspring: paradoxically enhanced appetite stimulation in fed and fasting states. Reprod Sci 2012;19:423430. [CrossRef]
  • [29] Qiu B, Bell RL, Cao Y, Zhang L, Stewart RB, Graves T, et al. Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight. J Genet Genomics 2016;43:421430. [CrossRef]
  • [30] Palou M, Sánchez J, Rodríguez AM, Priego T, Picó C, Palou A. Induction of NPY/AgRP orexigenic peptide expression in rat hypothalamus is an early event in fasting: relationship with circulating leptin, insulin and glucose. Cell Physiol Biochem 2009;23:115124. [CrossRef]
  • [31] Mariano IR, Yamada LA, Rabassi RS, Sabino VR, Bataglini C, Azevedo SC, et al. Differential responses of liver and hypothalamus to the nutritional condition during lactation and adult life. Front Physiol 2020;11:553. [CrossRef]
  • [32] Mercer JG, Moar KM, Logie TJ, Findlay PA, Adam CL, Morgan PJ. Seasonally inappropriate body weight induced by food restriction: effect on hypothalamic gene expression in male Siberian hamsters. Endocrinology 2001;142:41734181. [CrossRef]
  • [33] Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, et al. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 1997;278:135138. [CrossRef]
  • [34] Timper K, Brüning JC. Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity. Dis Model Mech 2017;10:679689. [CrossRef]
  • [35] Krashes MJ, Shah BP, Koda S, Lowell BB. Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP. Cell Metab 2013;18:588595. [CrossRef]
  • [36] Patton AP, Hastings MH. The suprachiasmatic nucleus. Curr Biol 2018;28:R816R822. [CrossRef]
  • [37] Haupt S, Eckstein ML, Wolf A, Zimmer RT, Wachsmuth NB, Moser O. Eat, train, sleep—retreat? Hormonal interactions of intermittent fasting, exercise and circadian rhythm. Biomolecules 2021;11:516. [CrossRef]
  • [38] Deem JD, Faber CL, Morton GJ. AgRP neurons: Regulators of feeding, energy expenditure, and behavior. FEBS J 2022;289:23622381. [CrossRef]
  • [39] Oster H, Damerow S, Kiessling S, Jakubcakova V, Abraham D, Tian J, et al. The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock. Cell Metab.2006;4:163173. [CrossRef]
Toplam 38 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Yapı (Diğer)
Bölüm Research Articles
Yazarlar

Pınar İnan Bu kişi benim 0000-0001-6760-1458

Bülent Gündüz 0000-0003-0497-8287

Yayımlanma Tarihi 4 Ekim 2024
Gönderilme Tarihi 11 Nisan 2023
Yayımlandığı Sayı Yıl 2024 Cilt: 42 Sayı: 5

Kaynak Göster

Vancouver İnan P, Gündüz B. Variation of NPY and AGRP MRNA expression in Syrian hamsters according to feeding times. SIGMA. 2024;42(5):1336-43.

IMPORTANT NOTE: JOURNAL SUBMISSION LINK https://eds.yildiz.edu.tr/sigma/