Histopathological Characterization of Hyperemia, Steatosis, Inflammatory Infiltration, and Necrosis in the Liver of Nemipterus randalli from the Gulf of Antalya (Türkiye)

Özlem Özmen; Gözde Aydoğan; Gülay Demirörs; Leyla Elif Özgü Ayözger; Deniz İnnal

Histopathological Characterization of Hyperemia, Steatosis, Inflammatory Infiltration, and Necrosis in the Liver of Nemipterus randalli from the Gulf of Antalya (Türkiye)

Abstract

The fish liver is a multifunctional metabolic organ that serves as a sensitive biomarker for evaluating the effects of environmental stressors on aquatic organisms. This study aimed to investigate the macroscopic and histopathological characteristics of the liver in the Lessepsian migrant Nemipterus randalli from the Antalya Gulf (Northeastern Mediterranean, Türkiye). A total of 24 specimens were collected on March 10, 2026, and subjected to morphometric analysis and histopathological examination. The mean total body length and weight were 17.8 cm (range: 14.9–21.5 cm) and 77.9 g (range: 40.2–126.0 g), respectively, with a female-to-male ratio of 1:0.8. The mean liver length, weight, and width were 19.6 mm, 0.5 g, and 10.4 mm, respectively. Histopathological evaluation of the hepatopancreas from 18 successfully fixed specimens revealed varying degrees of hyperemia, ranging from mild vascular hyperemia to pronounced circulatory disturbances. Lipid accumulation was observed at different severities, characterized by both microvesicular and macrovesicular steatosis within hepatocytes. Inflammatory cell infiltration, predominantly consisting of mononuclear cells, was evident, suggesting an ongoing inflammatory response. Additionally, focal to multifocal areas of necrosis were identified in several sections, accompanied by disruption of normal tissue architecture. Overall, these findings demonstrate a spectrum of degenerative and inflammatory changes in the hepatic tissue of N. randalli, highlighting the susceptibility of this organ to metabolic and/or toxic insults. The present study provides baseline histopathological data for this Lessepsian species and underscores the utility of liver histopathology as a tool for monitoring environmental stress in the Mediterranean ecosystem.

Keywords

References

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Details

Primary Language

English

Subjects

Animal Developmental and Reproductive Biology

Journal Section

Research Article

Authors

Özlem Özmen
0000-0002-1835-1082
Türkiye

Gözde Aydoğan
Türkiye

Gülay Demirörs
Türkiye

Leyla Elif Özgü Ayözger
0000-0003-3320-1688
Türkiye

Deniz İnnal ^*
0000-0002-1686-0959
Türkiye

Publication Date

June 25, 2026

Submission Date

May 7, 2026

Acceptance Date

June 16, 2026

Published in Issue

Year 2026 Volume: 2 Number: 1

IZ

https://izlik.org/JA97SY79KF

Cite

RIS / Bibtex

APA

Özmen, Ö., Aydoğan, G., Demirörs, G., Ayözger, L. E. Ö., & İnnal, D. (2026). Histopathological Characterization of Hyperemia, Steatosis, Inflammatory Infiltration, and Necrosis in the Liver of Nemipterus randalli from the Gulf of Antalya (Türkiye). Smyrna Journal of Natural and Data Sciences, 2(1), 27-39. https://izlik.org/JA97SY79KF

AMA

1.Özmen Ö, Aydoğan G, Demirörs G, Ayözger LEÖ, İnnal D. Histopathological Characterization of Hyperemia, Steatosis, Inflammatory Infiltration, and Necrosis in the Liver of Nemipterus randalli from the Gulf of Antalya (Türkiye). Smyrna Journal of Natural and Data Sciences. 2026;2(1):27-39. https://izlik.org/JA97SY79KF

Chicago

Özmen, Özlem, Gözde Aydoğan, Gülay Demirörs, Leyla Elif Özgü Ayözger, and Deniz İnnal. 2026. “Histopathological Characterization of Hyperemia, Steatosis, Inflammatory Infiltration, and Necrosis in the Liver of Nemipterus Randalli from the Gulf of Antalya (Türkiye)”. Smyrna Journal of Natural and Data Sciences 2 (1): 27-39. https://izlik.org/JA97SY79KF.

EndNote

Özmen Ö, Aydoğan G, Demirörs G, Ayözger LEÖ, İnnal D (June 1, 2026) Histopathological Characterization of Hyperemia, Steatosis, Inflammatory Infiltration, and Necrosis in the Liver of Nemipterus randalli from the Gulf of Antalya (Türkiye). Smyrna Journal of Natural and Data Sciences 2 1 27–39.

IEEE

[1]Ö. Özmen, G. Aydoğan, G. Demirörs, L. E. Ö. Ayözger, and D. İnnal, “Histopathological Characterization of Hyperemia, Steatosis, Inflammatory Infiltration, and Necrosis in the Liver of Nemipterus randalli from the Gulf of Antalya (Türkiye)”, Smyrna Journal of Natural and Data Sciences, vol. 2, no. 1, pp. 27–39, June 2026, [Online]. Available: https://izlik.org/JA97SY79KF

ISNAD

Özmen, Özlem - Aydoğan, Gözde - Demirörs, Gülay - Ayözger, Leyla Elif Özgü - İnnal, Deniz. “Histopathological Characterization of Hyperemia, Steatosis, Inflammatory Infiltration, and Necrosis in the Liver of Nemipterus Randalli from the Gulf of Antalya (Türkiye)”. Smyrna Journal of Natural and Data Sciences 2/1 (June 1, 2026): 27-39. https://izlik.org/JA97SY79KF.

JAMA

1.Özmen Ö, Aydoğan G, Demirörs G, Ayözger LEÖ, İnnal D. Histopathological Characterization of Hyperemia, Steatosis, Inflammatory Infiltration, and Necrosis in the Liver of Nemipterus randalli from the Gulf of Antalya (Türkiye). Smyrna Journal of Natural and Data Sciences. 2026;2:27–39.

MLA

Özmen, Özlem, et al. “Histopathological Characterization of Hyperemia, Steatosis, Inflammatory Infiltration, and Necrosis in the Liver of Nemipterus Randalli from the Gulf of Antalya (Türkiye)”. Smyrna Journal of Natural and Data Sciences, vol. 2, no. 1, June 2026, pp. 27-39, https://izlik.org/JA97SY79KF.

Vancouver

1.Özlem Özmen, Gözde Aydoğan, Gülay Demirörs, Leyla Elif Özgü Ayözger, Deniz İnnal. Histopathological Characterization of Hyperemia, Steatosis, Inflammatory Infiltration, and Necrosis in the Liver of Nemipterus randalli from the Gulf of Antalya (Türkiye). Smyrna Journal of Natural and Data Sciences [Internet]. 2026 Jun. 1;2(1):27-39. Available from: https://izlik.org/JA97SY79KF