Investigation of Neopterin Levels in Children with Hashimoto Thyroiditis

Yıl 2024, Cilt: 6 Sayı: 1, 1 - 10, 30.08.2024

Burhan Ertekin , Hacı Ömer Ateş

https://doi.org/10.55895/sshs.1322928

Öz

ABSTRACT
Objective: Hashimoto Thyroiditis is an autoimmune disease caused by genetic and environmental factors and is known as the most common cause of hypothyroidism in childhood. Neopterin has been measured in many autoimmune disorders and has been identified as a marker of cellular immune activation. The aim of this study was to investigate the autoimmune association of neopterin in patients with Hashimoto's Thyroiditis aged 5-18 years.

Material and Method: Neopterin levels were measured in 80 individuals, 40 of whom were followed up with the diagnosis of Hashimoto Thyroiditis and 40 of whom were not diagnosed with Hashimoto Thyroiditis.

Results: While the mean value of neopterin levels in the control group participating in this study was 86.4170 ± 3.59284, the mean value in the patient group was 101.32 ± 9.75378. When we look at the participant age data, it is seen that the patients and controls are compatible with each other (p>0.05). In addition, it is seen that there is a significant positive correlation p<0.05 between the variables of age-neopterin levels and tsh-neopterin levels.

Conclusion: In the study, when the individuals with Hashimoto's Thyroiditis between the ages of 5-18 were compared with the control group individuals in the same age range, no statistically significant difference ( p>0.05 ) was found between the neopterin levels.

Anahtar Kelimeler

Hashimoto Thyroiditis, ELISA, Neopterin

Kaynakça

• Barić, A., Brčić, L., Gračan, S., Torlak Lovrić, V., Gunjača, I., Šimunac, M., Brekalo, M., Boban, M., Polasek, O., Barbalic, M., Zemunik, T., Punda, A., & Boraska Perica, V. (2017). Association of established hypothyroidism-associated genetic variants with Hashimoto’s thyroiditis. J Endocrinol Invest, 40, 1061-1067. doi: 10.1007/s40618-017-0660-8
• Baydar, T., Palabiyik, S., Sahin, G. (2009). Neopterin: Günümüzün Popüler Biyogöstergesi mi? Türkiye Klinikleri Tıp Bilimleri Dergisi, 29(5), 1280-1291.
• Berdowska, A. & Zwirska‐Korczala, K. (2001). Neopterin measurement in clinical diagnosis. J Clin Pharm Ther., 26(5), 319-329. doi: 10.1046/j.1365-2710.2001.00358.x
• Eisenhut, M. (2013). Neopterin in diagnosis and monitoring of infectious diseases. J Biomark., 2013(1), 196432. doi: 10.1155/2013/196432
• Fuchs, D., Avanzas, P., Arroyo-Espliguero, R., Jenny, M., Consuegra-Sanchez, L., & Kaski, J. C. (2009). The role of neopterin in atherogenesis and cardiovascular risk assessment. Curr Med Chem., 16(35), 4644-4653. doi: 10.2174/092986709789878247
• Gülkesen, A., Akgöl, G., Tuncer, T., Kal, G. A., Selda, T., Poyraz, A. K., & Arzu, K. (2016). Relationship between leptin and neopterin levels and disease activation parameters in patients with rheumatoid arthritis. Arch Rheumatol., 31(4), 333. doi: 10.5606/ArchRheumatol.2016.5893
• Hamerlinck, F. F. (1999). Neopterin: a review. Exp Dermatol, 8(3), 167-176. doi: 10.1111/j.1600-0625.1999.tb00367.x Kondera-Anasz, Z., & Mertas, A. (1999). Level of serum neopterin and interleukin-6 in patients with thyroid diseases. Pteridines, 10(4), 197-201. doi.org/10.1515/pteridines.1999.10.4.197
• Liontiris, M. I., & Mazokopakis, E. E. (2017). A concise review of Hashimoto thyroiditis (HT) and the importance of iodine, selenium, vitamin D and gluten on the autoimmunity and dietary management of HT patients. Points that need more investigation. Hell J Nucl Med., 20(1), 51-56. doi: 10.1967/s002449910507
• Michalak, Ł., Bulska, M., Strząbała, K., & Szcześniak, P. (2017). Neopteryna jako marker komórkowej odpowiedzi immunologicznej. Postepy Hig Med Dosw., 71, 727-736.doi: 10.5604/01.3001.0010.3851
• Mutluay, R., & Yeğin, Z. A. (2003). Hashimoto Tiroiditi (Kronik Lenfositik Tiroidit, Struma Lymphomatosa)
• Plata-Nazar, K., Szumera, M., Łuczak, G., Liberek, A., Sznurkowska, K., Szlagatys-Sidorkiewicz, A., Lange, M., & Kamińska, B. (2015). Clinical usefulness of serum neopterin in children with juvenile idiopathic arthritis. Pteridines, 26(2), 69-72. doi: 10.1515/pterid-2015-0003
• Wagner, R., Hayatghebi, S., Rosenkranz, M., & Reinwein, D. (1993). Increased serum neopterin levels in patients with Graves' disease. Exp Clin Endocrinol, 101(04), 249-254. doi: 10.1055/s-0029-1211240
• Zdraveska, N., & Kocova M. (2012). Hashimoto thyroiditis in childhood–review of the epidemiology, genetic susceptibility and clinical aspects of the disease.Macedonian Journal of Medical Sciences, 5(3), 336-345. doi: 10.3889/MJMS.1857-5773.2012.0247