KİTOSAN/ter(GMA-MA-NTBA) POLİMER İLE MİKROKAPSÜL HAZIRLAMA VE KARAKTERİZASYONU

Yıl 2019, Cilt: 7 Sayı: 2, 524 - 535, 01.06.2019

İdris Sargın

https://doi.org/10.15317/Scitech.2019.216

Öz

Bu
çalışmada, glisidil metakrilat (GMA), maleik anhidrit (MA), N-ter-butilakrilamid (NTBA) monomerlerinden
ter(GMA-MA-NTBA) polimer ilk kez sentezlenmiştir. Polimerin kimyasal yapısı FT‐IR
spektroskopisi, Nükleer Manyetik Rezonans (¹H-NMR) spektroskopisi,
asit sayısı ve viskozite ölçümleri ile yüzey morfolojisi taramalı elektron
mikroskobu (SEM) ile çalışılmıştır. Sentezlenen ter(GMA-MA-NTBA) polimerin
farklı oranlarını içeren kitosan tabanlı mikrokapsüller hazırlanmış ve yapısal kararlılığı optimize edilmiştir. Polimer-kitosan mikrokapsüller gluteraldehit çapraz bağlayıcı ile daha dayanıklı hale getirilmiştir. Mikrokapsüllerin kimyasal
yapıları FT‐IR spektroskopisi ile yüzey morfolojileri SEM ile belirlenmiştir. Kitosan/ter(GMA-MA-NTBA)
polimer kompozit mikrokapsüller farklı adsorpsiyon, ilaç taşıma ya da kontrollü
salınım uygulamalarında denenebilir. 

Anahtar Kelimeler

Kitosan mikrokapsül, ter-Polimer, SEM

Preparation and Characterization of Chitosan/ter(GMA-MA-NTBA) Polymer Microcapsules

Öz

In
this study, ter(GMA-MA-NTBA) polymer was synthesized from glycidyl
methacrylate(GA); maleic anhydride (MA) and N-tert-butylacrylamide
(NTBA) monomers for the first time. Chemical structure of the polymer was studied
using FT-IR spectroscopy, Nuclear Magnetic Resonance (¹H-NMR)
spectroscopy, acidic group number and viscosity measurements and its surface
morphology using scanning electron microscopy (SEM). Chitosan-based
microcapsules containing different ratios of the synthesized ter(GMA-MA-NTBA)
polymer were prepared and their structural stability was optimized. The
microcapsules were cross-linked with glutaraldehyde to make them mechanically
stronger. Chemical structure of the microcapsules was determined using FT-IR
spectroscopy and their surface their surface morphology using SEM. Chitosan/ter(GMA-MA-NTBA)
polymer composite microcapsules can be tested in adsorption, drug delivery and
controlled release applications.

Anahtar Kelimeler

Chitosan microcapsule, ter-Polymer, SEM

Kaynakça

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