Could Zingiber officinale plant be effective against Omicron BA.2.75 of SARS-CoV-2?

Year 2023, Volume: 7 Issue: 3, 42 - 56, 03.09.2023

Handan Saraç , Ahmet Demirbaş , Burak Tüzün

https://doi.org/10.33435/tcandtc.1198612

Cited By: 2

Abstract

Zingiber officinale plant was examined in this study. The chemicals found in this plant were identified using the GC-MS method. The activities of the determined chemical molecules against the SARS-CoV-2 Omicron variant were compared. We focused to determine whether Zingiber officinale plant would be an inhibitor against Omicron of SARS-CoV-2 in silico. As a result of theoretical calculations, Zingiber officinale plant was found to contain many chemicals as a result of GC-MS analysis. These chemicals were detected one by one and their activity values were calculated for the SARS-CoV-2 virus. As a result, molecules with high activity were detected. ADME/T properties were investigated in order to examine the drug properties of molecules with high activity. According to ADME/T results, these five molecules examined are suitable for use in human metabolism as drug molecules.

Keywords

Zingiber officinale, SARS-CoV-2, omicron, molecular docking, ADME/T

Project Number

RGD-020

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