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The Relationship Between Esophageal Corrosion and Dynamic Thiol-Disulfide and Ischemia Modified Albumin Levels in Children

Yıl 2021, Cilt , Sayı , 1 - 6, 30.01.2020
https://doi.org/10.12956/tchd.933755

Öz

Objective: Corrosive burns of esophagus occurring in childhood has life-threatening complications. Its detection via biochemical substrates instead of performing esophagoscopy is crucially important for children. Determination of oxidative stress markers including thiol/disulfide homeostasis and ischemia modified albumin levels may provide valuable information for corrosive esophageal burns. The study aims to investigate the relation between esophageal corrosion and thiol/disulfide homeostasis and ischemia-modified albumin levels in children.

Material and Methods: Eighteen patients who underwent esophagoscopy due to corrosive substances intake (esophagoscopy group) and age and gender-matched 18 volunteers (control group) were included study. Blood levels of native thiol (-SH), total thiol (SH+SS), dynamic disulfide (SS), albumin and ischemia modified albumin (IMA) were measured in both groups. SPSS 17.0 was used for analyses and p <0.05 was considered significant.

Results: Laboratory results of cases with esophageal burn (n = 13) and without burn (n = 5) and control (n = 18) were compared. There was a significant decrease in levels of dynamic disulfide (p=0.03), and dynamic disulfide/total thiol ratio (p=0.01) of children with esophageal burn compared with that of children with no burn or were found to be statistically significant.

Conclusion: Decreased levels of disulphide and dynamic disulfide/total thiol ratio would be used as a laboratory test to show corrosion in the esophagus. However, randomized, multicentric studies with larger samples are needed.

Kaynakça

  • 1 - de Jong AL, Macdonald R, Ein S, Forte V, Turner A. Corrosive esophagitis in children: a 30-year review. Int J Pediatr Otorhinolaryngol 2001;57:203-11.
  • 2- Huang YC, Ni YH, Lai HS, Chang MH. Corrosive esophagitis in children. Pediatr Surg Int 2004;20:207-10.
  • 3- Chiu HM, Lin JT, Huang SP, Chen CH, Yang CS, Wang HP. Prediction of bleeding and stricture formation after corrosive ingestion by EUS concurrent with upper endoscopy. Gastrointest Endosc 2004;60:827-33.
  • 4- Boskovic A, Stankovic I. Predictability of gastroesophageal caustic injury from clinical findings: is endoscopy mandatory in children? Eur J Gastroenterol Hepatol 2014;26:499-503.
  • 5- Betalli P, Falchetti D, Giuliani S, Pane A, Dall’Oglio L, de Angelis GL, et al. Caustic ingestion in children: is endoscopy always indicated? The results of an Italian multicenter observational study. Gastrointest Endosc 2008;68:434-9.
  • 6- Gupta SK, Croffie JM, Fitzgerald JF. Is esophagogastroduodenoscopy necessary in all caustic ingestions? J Pediatr Gastroenterol Nutr 2001;32:50-3.
  • 7- Havanond C, Havanond P: Initial signs and symptoms as prognostic indicators of severe gastrointestinal tract injury due to corrosive ingestion. J Emerg Med 2007;33:349-53.
  • 8- Saugstad OD. Mechanisms of tissue injury by oxygen radicals: implications for neonatal disease. Acta Paediatr 1996;85:1-4.
  • 9- Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007;39:44-84.
  • 10- Bolukbas C, Bolukbas FF, Horoz M, Aslan M, Celik H, Erel O. Increased oxidative stress associated with the severity of the liver disease in various forms of hepatitis B virus infection. BMC Infect Dis 2005;5:95. https://doi.org/10.1186/1471-2334-5-95.
  • 11- Ozdogan M, Devay AO, Gurer A, Ersoy E, Devay SD, Kulacoglu H, et al. Plasma total anti-oxidant capacity correlates inversely with the extent of acute appendicitis: a case control study. World J Emerg Surg 2006;1:6. https://doi.org/10.1186/1749-7922-1-6.
  • 12- Serefhanoglu K, Taskin A, Turan H, Timurkaynak FE, Arslan H, Erel O. Evaluation of oxidative status in patients with brucellosis. Braz J Infect Dis 2009;13:249-51.
  • 13- Ozel SK, Dagli TE, Yuksel M, Kiyan G, Kotiloglu E. The roles of free oxygen radicals, nitric oxide, and endothelin in caustic injury of rat esophagus. J Pediatr Surg 2004;39:1381-5.
  • 14- Gunel E, Caglayan F, Caglayan O, Akillioglu I. Reactive oxygen radical levels in caustic esophageal burns. J Pediatr Surg 1999;34:405-7.
  • 15- Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014;47:326-32.
  • 16- Sen CK, Packer L. Thiol homeostasis and supplements in physical exercise. Am J Clin Nutr 2000;72:653S-69S.
  • 17- Wudkowska A, Goch J, Goch A. Ischemia-modified albumin in differential diagnosis of acute coronary syndrome without ST elevation and unstable angina pectoris. Kardiol Pol 2010;68:431-7.
  • 18- Aran T, Unsal MA, Guven S, Kart C, Cetin EC, Alver A. Carbon dioxide pneumoperitoneum induces systemic oxidative stress: a clinical study. Eur J Obstet Gynecol Reprod Biol 2012;161:80-3.
  • 19- Ma SG, Wei CL, Hong B, Yu WN. Ischemia-modified albumin in type 2 diabetic patients with and without peripheral arterial disease. Clinics (Sao Paulo) 2011;66:1677-80.
  • 20- Mastella AK, Moresco RN, da Silva DB, Becker AM, Duarte MM, Giovelli LL, et al. Evaluation of ischemia-modified albumin in myocardial infarction and prostatic diseases. Biomed Pharmacother 2009;63:762-6.
  • 21- Lippi G, Montagnana M. Ischemia-modified albumin in ischemic disorders. Ann Thorac Cardiovasc Surg 2009;15:137.
  • 22-Bar-Or D, Lau E, Winkler JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia-a preliminary report. J Emerg Med 2000;19:311-5.
  • 23-Gaudreault P, Parent M, McGuigan MA, Chicoine L, Lovejoy FH, Jr. Predictability of esophageal injury from signs and symptoms: a study of caustic ingestion in 378 children. Pediatrics 1983;71:767-70.
  • 24-Temiz A, Oguzkurt P, Ezer SS, Ince E, Hicsonmez A. Predictability of outcome of caustic ingestion by esophagogastroduodenoscopy in children. World J Gastroenterol 2012;18:1098-103.

Çocuklarda Özefagus Korozyonu ile Dinamik Tiyol-Disülfid ve İskemi Modifiye Albumin Düzeyleri Arasındaki İlişki

Yıl 2021, Cilt , Sayı , 1 - 6, 30.01.2020
https://doi.org/10.12956/tchd.933755

Öz

Amaç: Çocukluk çağında özoagusun korozif yanıkları hayatı tehdit eden ciddi bir durumdur. Çocuklarda korozif tanısı koymada özefagoskopi yapmak yerine biyokimyasal marker ile saptamak çok önemlidir. Oksidatif stres belirteçlerinden tiyol / disülfid homeostazı ve iskemi modifiye albümin seviyelerinin belirlenmesi, korozif özofagus yanıkları için tanısal bilgiler sağlayabilir. Çalışma, çocuklarda özofagus korozyonu ile tiyol / disülfid homeostazı ve iskemi modifiye albümin düzeyleri arasındaki ilişkiyi araştırmayı amaçlamaktır.

Gereç ve Yöntemler: Çalışmaya, korozif madde alımı nedeni ile özofagoskopi yapılan 18 hasta (özofagoskopi grubu) ve yaş ve cinsiyet uyumlu 18 gönüllü (kontrol grubu) dâhil edildi. Her iki grupta nativ tiyol (-SH), toplam tiyol (SH+SS), dinamik disülfid (SS), albümin ve iskemi modifiye albümin (İMA) kan seviyeleri ölçüldü. Analizler için SPSS 17.0 kullanıldı ve p <0.05 anlamlı kabul edildi.

Bulgular: Özofagus yanığı olan (n = 13) ve yanık olmayan (n = 5) olguların ve kontrol grubunun (n = 18) laboratuvar sonuçları karşılaştırıldı. Özofagus yanığı olan çocukların dinamik disülfid düzeylerinde (p=0.03) ve dinamik disülfid / toplam tiyol oranında (p=0.01) yanık olmayan çocuklara göre azalma görüldü veya istatistiksel olarak anlamlı bulundu.

Sonuç: Disülfid seviyesi ve dinamik disülfid / total tiyol oranının azalmasından dolayı özefagus korozyonu göstermek için bir laboratuvar testi olarak kullanılabilir. Ancak, çok merkezli, randomize, daha fazla örneklemli çalışmalara ihtiyaç vardır.

Kaynakça

  • 1 - de Jong AL, Macdonald R, Ein S, Forte V, Turner A. Corrosive esophagitis in children: a 30-year review. Int J Pediatr Otorhinolaryngol 2001;57:203-11.
  • 2- Huang YC, Ni YH, Lai HS, Chang MH. Corrosive esophagitis in children. Pediatr Surg Int 2004;20:207-10.
  • 3- Chiu HM, Lin JT, Huang SP, Chen CH, Yang CS, Wang HP. Prediction of bleeding and stricture formation after corrosive ingestion by EUS concurrent with upper endoscopy. Gastrointest Endosc 2004;60:827-33.
  • 4- Boskovic A, Stankovic I. Predictability of gastroesophageal caustic injury from clinical findings: is endoscopy mandatory in children? Eur J Gastroenterol Hepatol 2014;26:499-503.
  • 5- Betalli P, Falchetti D, Giuliani S, Pane A, Dall’Oglio L, de Angelis GL, et al. Caustic ingestion in children: is endoscopy always indicated? The results of an Italian multicenter observational study. Gastrointest Endosc 2008;68:434-9.
  • 6- Gupta SK, Croffie JM, Fitzgerald JF. Is esophagogastroduodenoscopy necessary in all caustic ingestions? J Pediatr Gastroenterol Nutr 2001;32:50-3.
  • 7- Havanond C, Havanond P: Initial signs and symptoms as prognostic indicators of severe gastrointestinal tract injury due to corrosive ingestion. J Emerg Med 2007;33:349-53.
  • 8- Saugstad OD. Mechanisms of tissue injury by oxygen radicals: implications for neonatal disease. Acta Paediatr 1996;85:1-4.
  • 9- Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007;39:44-84.
  • 10- Bolukbas C, Bolukbas FF, Horoz M, Aslan M, Celik H, Erel O. Increased oxidative stress associated with the severity of the liver disease in various forms of hepatitis B virus infection. BMC Infect Dis 2005;5:95. https://doi.org/10.1186/1471-2334-5-95.
  • 11- Ozdogan M, Devay AO, Gurer A, Ersoy E, Devay SD, Kulacoglu H, et al. Plasma total anti-oxidant capacity correlates inversely with the extent of acute appendicitis: a case control study. World J Emerg Surg 2006;1:6. https://doi.org/10.1186/1749-7922-1-6.
  • 12- Serefhanoglu K, Taskin A, Turan H, Timurkaynak FE, Arslan H, Erel O. Evaluation of oxidative status in patients with brucellosis. Braz J Infect Dis 2009;13:249-51.
  • 13- Ozel SK, Dagli TE, Yuksel M, Kiyan G, Kotiloglu E. The roles of free oxygen radicals, nitric oxide, and endothelin in caustic injury of rat esophagus. J Pediatr Surg 2004;39:1381-5.
  • 14- Gunel E, Caglayan F, Caglayan O, Akillioglu I. Reactive oxygen radical levels in caustic esophageal burns. J Pediatr Surg 1999;34:405-7.
  • 15- Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014;47:326-32.
  • 16- Sen CK, Packer L. Thiol homeostasis and supplements in physical exercise. Am J Clin Nutr 2000;72:653S-69S.
  • 17- Wudkowska A, Goch J, Goch A. Ischemia-modified albumin in differential diagnosis of acute coronary syndrome without ST elevation and unstable angina pectoris. Kardiol Pol 2010;68:431-7.
  • 18- Aran T, Unsal MA, Guven S, Kart C, Cetin EC, Alver A. Carbon dioxide pneumoperitoneum induces systemic oxidative stress: a clinical study. Eur J Obstet Gynecol Reprod Biol 2012;161:80-3.
  • 19- Ma SG, Wei CL, Hong B, Yu WN. Ischemia-modified albumin in type 2 diabetic patients with and without peripheral arterial disease. Clinics (Sao Paulo) 2011;66:1677-80.
  • 20- Mastella AK, Moresco RN, da Silva DB, Becker AM, Duarte MM, Giovelli LL, et al. Evaluation of ischemia-modified albumin in myocardial infarction and prostatic diseases. Biomed Pharmacother 2009;63:762-6.
  • 21- Lippi G, Montagnana M. Ischemia-modified albumin in ischemic disorders. Ann Thorac Cardiovasc Surg 2009;15:137.
  • 22-Bar-Or D, Lau E, Winkler JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia-a preliminary report. J Emerg Med 2000;19:311-5.
  • 23-Gaudreault P, Parent M, McGuigan MA, Chicoine L, Lovejoy FH, Jr. Predictability of esophageal injury from signs and symptoms: a study of caustic ingestion in 378 children. Pediatrics 1983;71:767-70.
  • 24-Temiz A, Oguzkurt P, Ezer SS, Ince E, Hicsonmez A. Predictability of outcome of caustic ingestion by esophagogastroduodenoscopy in children. World J Gastroenterol 2012;18:1098-103.

Ayrıntılar

Birincil Dil İngilizce
Konular Cerrahi
Bölüm ÖZGÜN ARAŞTIRMALAR
Yazarlar

Can İhsan ÖZTORUN (Sorumlu Yazar)
ANKARA YILDIRIM BEYAZIT ÜNİVERSİTESİ TIP FAKÜLTESİ ÇOCUK CERRAHİSİ A.B.D.
0000-0002-5408-2772
Türkiye


Gökhan DEMİRTAŞ
SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, ÇOCUK CERRAHİSİ ANABİLİM DALI
0000-0003-0787-2330
Türkiye


Sabri DEMİR
SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, ÇOCUK CERRAHİSİ ANABİLİM DALI
0000-0003-4720-912X
Türkiye


Doğuş GÜNEY
ANKARA YILDIRIM BEYAZIT ÜNİVERSİTESİ, TIP FAKÜLTESİ
0000-0001-7168-2123
Türkiye


Rabia DEMİR
ŞIRNAK DEVLET HASTANESİ
0000-0001-7979-5317
Türkiye


Süleyman Arif BOSTANCI
SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, ÇOCUK CERRAHİSİ ANABİLİM DALI
0000-0002-7512-3895
Türkiye


Ahmet ERTÜRK
SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, ÇOCUK CERRAHİSİ ANABİLİM DALI
0000-0002-8156-5665
Türkiye


Ali GÜNGÖR
SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA DR. SAMİ ULUS KADIN DOĞUM ÇOCUK SAĞLIĞI VE HASTALIKLARI SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
0000-0003-4139-3480
Türkiye


Aysun KARA UZUN
ANKARA ŞEHİR HASTANESİ ÇOCUK HASTANESİ PEDİATRİ KLİNİĞİ
0000-0002-1028-5949
Türkiye


Gamze AVCIOĞLU Bu kişi benim
ANKARA YILDIRIM BEYAZIT ÜNİVERSİTESİ TIP FAKÜLTESİ TIBBI BİYOKİMYA ANABİLİM DALI
0000-0003-0819-528X
Türkiye


Salim NEŞELİOĞLU
ANKARA YILDIRIM BEYAZIT ÜNİVERSİTESİ TIP FAKÜLTESİ TIBBI BİYOKİMYA A.B.D.
0000-0002-0974-5717
Türkiye


Emrah ŞENEL
ANKARA YILDIRIM BEYAZIT ÜNİVERSİTESİ TIP FAKÜLTESİ ÇOCUK CERRAHİSİ A.B.D.
0000-0002-0383-4559
Türkiye

Yayımlanma Tarihi 30 Ocak 2020
Başvuru Tarihi 6 Mayıs 2021
Kabul Tarihi 6 Temmuz 2021
Yayınlandığı Sayı Yıl 2021, Cilt , Sayı

Kaynak Göster

Bibtex @araştırma makalesi { tchd933755, journal = {Türkiye Çocuk Hastalıkları Dergisi}, issn = {1307-4490}, eissn = {2148-3566}, address = {Şehit Ömer Halisdemir Cad. Kurtdereli Sok. No:10 ANKARA}, publisher = {T.C. Sağlık Bakanlığı Ankara Şehir Hastanesi}, year = {2020}, volume = {}, pages = {1 - 6}, doi = {10.12956/tchd.933755}, title = {The Relationship Between Esophageal Corrosion and Dynamic Thiol-Disulfide and Ischemia Modified Albumin Levels in Children}, key = {cite}, author = {Öztorun, Can İhsan and Demirtaş, Gökhan and Demir, Sabri and Güney, Doğuş and Demir, Rabia and Bostancı, Süleyman Arif and Ertürk, Ahmet and Güngör, Ali and Kara Uzun, Aysun and Avcıoğlu, Gamze and Neşelioğlu, Salim and Şenel, Emrah} }
APA Öztorun, C. İ. , Demirtaş, G. , Demir, S. , Güney, D. , Demir, R. , Bostancı, S. A. , Ertürk, A. , Güngör, A. , Kara Uzun, A. , Avcıoğlu, G. , Neşelioğlu, S. & Şenel, E. (2020). The Relationship Between Esophageal Corrosion and Dynamic Thiol-Disulfide and Ischemia Modified Albumin Levels in Children . Türkiye Çocuk Hastalıkları Dergisi , , 1-6 . DOI: 10.12956/tchd.933755
MLA Öztorun, C. İ. , Demirtaş, G. , Demir, S. , Güney, D. , Demir, R. , Bostancı, S. A. , Ertürk, A. , Güngör, A. , Kara Uzun, A. , Avcıoğlu, G. , Neşelioğlu, S. , Şenel, E. "The Relationship Between Esophageal Corrosion and Dynamic Thiol-Disulfide and Ischemia Modified Albumin Levels in Children" . Türkiye Çocuk Hastalıkları Dergisi (2020 ): 1-6 <https://dergipark.org.tr/tr/pub/tchd/issue/43771/933755>
Chicago Öztorun, C. İ. , Demirtaş, G. , Demir, S. , Güney, D. , Demir, R. , Bostancı, S. A. , Ertürk, A. , Güngör, A. , Kara Uzun, A. , Avcıoğlu, G. , Neşelioğlu, S. , Şenel, E. "The Relationship Between Esophageal Corrosion and Dynamic Thiol-Disulfide and Ischemia Modified Albumin Levels in Children". Türkiye Çocuk Hastalıkları Dergisi (2020 ): 1-6
RIS TY - JOUR T1 - The Relationship Between Esophageal Corrosion and Dynamic Thiol-Disulfide and Ischemia Modified Albumin Levels in Children AU - Can İhsan Öztorun , Gökhan Demirtaş , Sabri Demir , Doğuş Güney , Rabia Demir , Süleyman Arif Bostancı , Ahmet Ertürk , Ali Güngör , Aysun Kara Uzun , Gamze Avcıoğlu , Salim Neşelioğlu , Emrah Şenel Y1 - 2020 PY - 2020 N1 - doi: 10.12956/tchd.933755 DO - 10.12956/tchd.933755 T2 - Türkiye Çocuk Hastalıkları Dergisi JF - Journal JO - JOR SP - 1 EP - 6 VL - IS - SN - 1307-4490-2148-3566 M3 - doi: 10.12956/tchd.933755 UR - https://doi.org/10.12956/tchd.933755 Y2 - 2021 ER -
EndNote %0 Türkiye Çocuk Hastalıkları Dergisi The Relationship Between Esophageal Corrosion and Dynamic Thiol-Disulfide and Ischemia Modified Albumin Levels in Children %A Can İhsan Öztorun , Gökhan Demirtaş , Sabri Demir , Doğuş Güney , Rabia Demir , Süleyman Arif Bostancı , Ahmet Ertürk , Ali Güngör , Aysun Kara Uzun , Gamze Avcıoğlu , Salim Neşelioğlu , Emrah Şenel %T The Relationship Between Esophageal Corrosion and Dynamic Thiol-Disulfide and Ischemia Modified Albumin Levels in Children %D 2020 %J Türkiye Çocuk Hastalıkları Dergisi %P 1307-4490-2148-3566 %V %N %R doi: 10.12956/tchd.933755 %U 10.12956/tchd.933755
ISNAD Öztorun, Can İhsan , Demirtaş, Gökhan , Demir, Sabri , Güney, Doğuş , Demir, Rabia , Bostancı, Süleyman Arif , Ertürk, Ahmet , Güngör, Ali , Kara Uzun, Aysun , Avcıoğlu, Gamze , Neşelioğlu, Salim , Şenel, Emrah . "The Relationship Between Esophageal Corrosion and Dynamic Thiol-Disulfide and Ischemia Modified Albumin Levels in Children". Türkiye Çocuk Hastalıkları Dergisi / (Ocak 2020): 1-6 . https://doi.org/10.12956/tchd.933755
AMA Öztorun C. İ. , Demirtaş G. , Demir S. , Güney D. , Demir R. , Bostancı S. A. , Ertürk A. , Güngör A. , Kara Uzun A. , Avcıoğlu G. , Neşelioğlu S. , Şenel E. The Relationship Between Esophageal Corrosion and Dynamic Thiol-Disulfide and Ischemia Modified Albumin Levels in Children. Türkiye Çocuk Hast Derg. 2020; 1-6.
Vancouver Öztorun C. İ. , Demirtaş G. , Demir S. , Güney D. , Demir R. , Bostancı S. A. , Ertürk A. , Güngör A. , Kara Uzun A. , Avcıoğlu G. , Neşelioğlu S. , Şenel E. The Relationship Between Esophageal Corrosion and Dynamic Thiol-Disulfide and Ischemia Modified Albumin Levels in Children. Türkiye Çocuk Hastalıkları Dergisi. 2020; 1-6.
IEEE C. İ. Öztorun , G. Demirtaş , S. Demir , D. Güney , R. Demir , S. A. Bostancı , A. Ertürk , A. Güngör , A. Kara Uzun , G. Avcıoğlu , S. Neşelioğlu ve E. Şenel , "The Relationship Between Esophageal Corrosion and Dynamic Thiol-Disulfide and Ischemia Modified Albumin Levels in Children", Türkiye Çocuk Hastalıkları Dergisi, ss. 1-6, Oca. 2020, doi:10.12956/tchd.933755

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