İnhibitörlü Hemofili A Hastalarında Profilaksi

Yıl 2012, Cilt: 6 Sayı: 4, 245 - 248, 01.04.2012

Vildan Çulha Dilek Gökçebay Özlem A. Bilir M.fatih Azık Betül Tavil Pamir Işık Neşe Yaralı Abdurrahman Kara Bahattin Tunç

Öz

Aktive protrombin kompleks konsantresi (aPCC) ve rekombinant faktör VIIa (rFVIIa) inhibitör geliştirmiş hemofili hastalarının kanama tedavisinde ve profilaksisinde kullanılmaktadır. Ülkemizde rFVIIa için profilakside endikasyon onayı ve geri ödemesi henüz yoktur. Bu yazıda inhibitörlü hastada aPCC’nin doz ve etkinliği değerlendirilmiştir. Her üç vakamızda da aPCC profilaksisi alırken kanamanın olmaması, iki hastada profilaksi kesildikten sonra tekrarlayan kanamaların görülmesi profilaksi süresinin uzatılabileceğini desteklemektedir.

Anahtar Kelimeler

Hemofili A, inhibitör, profilaksi

PROPHYLAXIS FOR HEMOPHILIA A PATIENTS WITH INHIBITORS

Öz

Use of activated prothrombin complex concentrate (aPCC) and recombinant factor VIIa (rFVIIa) is indicated for the treatment and prophylaxis of hemophiliac patients who has developed inhibitors. rFVIIa is an off labeled drug for prophylaxis in Turkey and not covered by health insurance. In this manuscript, the efficacy and dosage for aPCC prophylaxis were evaluated. During the aPCC prophylaxis, bleeding did not occur in any of the three cases. However, two patients developed recurrent bleeding attacks after the prophylaxis ceased. Therefore, we suggest that prophylaxis by aPCC should be prolonged to prevent recurrent bleeding attacks in hemophiliacs who developed inhibitors

Anahtar Kelimeler

Hemophilia A, inhibitory, prophylaxis

Kaynakça

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