Araştırma Makalesi
BibTex RIS Kaynak Göster
Yıl 2021, Cilt: 2 Sayı: 2, 40 - 47, 30.05.2021
https://doi.org/10.51972/tfsd.848202

Öz

Kaynakça

  • Abdulillah Ece, Biruni Üniversity. aece@biruni.edu.tr
  • Cenk Andaç, İstinye Üniversity cenk_andac@yahoo.com

Extracts of Mesua Ferrea Linn, the natural Inhibitors of COVID-19 main protease: a computational quest

Yıl 2021, Cilt: 2 Sayı: 2, 40 - 47, 30.05.2021
https://doi.org/10.51972/tfsd.848202

Öz

The coronavirus, known as severe acute respiratory syndrome (SARS-CoV-2), is accountable for the global epidemic disease COVID-19. The effective treatment of this disease is still unknown and there is an emergent need to use all resources to find the effective medication. The use of off-label natural medicinal compounds may be effective remedy for this scourge. Towards the investigation of effective inhibitor of 3CL protease, we studied the in silico interaction of the selected compounds of Mesua Ferrae Linn, an Asian medicinal plant. The studied compounds have shown excellent inhibition properties. The timber extracts, Mesuabixanthone-B (∆Gbind = -15.51 kcal/mol) and Mesuferrol-B (∆Gbind = -14.32 kcal/mol) are among the exciting hits on 6LU7. The in silico prediction of toxicities of the extracts are also promising. The further lab research is necessary to testify these drug candidates against COVID-19 infections.

Kaynakça

  • Abdulillah Ece, Biruni Üniversity. aece@biruni.edu.tr
  • Cenk Andaç, İstinye Üniversity cenk_andac@yahoo.com
Toplam 2 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Biyokimya ve Hücre Biyolojisi (Diğer)
Bölüm Makaleler
Yazarlar

Aisha Saddiqa

Osman Çakmak 0000-0001-9293-5572

Muhammad Usman

Salih Ökten 0000-0001-9656-1803

Yayımlanma Tarihi 30 Mayıs 2021
Gönderilme Tarihi 28 Aralık 2020
Kabul Tarihi 9 Nisan 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 2 Sayı: 2

Kaynak Göster

APA Saddiqa, A., Çakmak, O., Usman, M., Ökten, S. (2021). Extracts of Mesua Ferrea Linn, the natural Inhibitors of COVID-19 main protease: a computational quest. Turkish Journal of Science and Health, 2(2), 40-47. https://doi.org/10.51972/tfsd.848202








Turkish Journal of Science and Health (TFSD) 

E-mail:  tfsdjournal@gmail.com

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