Research Article
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Year 2021, Volume: 2 Issue: 2, 40 - 47, 30.05.2021
https://doi.org/10.51972/tfsd.848202

Abstract

References

  • Abdulillah Ece, Biruni Üniversity. aece@biruni.edu.tr
  • Cenk Andaç, İstinye Üniversity cenk_andac@yahoo.com

Extracts of Mesua Ferrea Linn, the natural Inhibitors of COVID-19 main protease: a computational quest

Year 2021, Volume: 2 Issue: 2, 40 - 47, 30.05.2021
https://doi.org/10.51972/tfsd.848202

Abstract

The coronavirus, known as severe acute respiratory syndrome (SARS-CoV-2), is accountable for the global epidemic disease COVID-19. The effective treatment of this disease is still unknown and there is an emergent need to use all resources to find the effective medication. The use of off-label natural medicinal compounds may be effective remedy for this scourge. Towards the investigation of effective inhibitor of 3CL protease, we studied the in silico interaction of the selected compounds of Mesua Ferrae Linn, an Asian medicinal plant. The studied compounds have shown excellent inhibition properties. The timber extracts, Mesuabixanthone-B (∆Gbind = -15.51 kcal/mol) and Mesuferrol-B (∆Gbind = -14.32 kcal/mol) are among the exciting hits on 6LU7. The in silico prediction of toxicities of the extracts are also promising. The further lab research is necessary to testify these drug candidates against COVID-19 infections.

References

  • Abdulillah Ece, Biruni Üniversity. aece@biruni.edu.tr
  • Cenk Andaç, İstinye Üniversity cenk_andac@yahoo.com
There are 2 citations in total.

Details

Primary Language English
Subjects Biochemistry and Cell Biology (Other)
Journal Section Articles
Authors

Aisha Saddiqa

Osman Çakmak 0000-0001-9293-5572

Muhammad Usman

Salih Ökten 0000-0001-9656-1803

Publication Date May 30, 2021
Submission Date December 28, 2020
Acceptance Date April 9, 2021
Published in Issue Year 2021 Volume: 2 Issue: 2

Cite

APA Saddiqa, A., Çakmak, O., Usman, M., Ökten, S. (2021). Extracts of Mesua Ferrea Linn, the natural Inhibitors of COVID-19 main protease: a computational quest. Turkish Journal of Science and Health, 2(2), 40-47. https://doi.org/10.51972/tfsd.848202








Turkish Journal of Science and Health (TFSD) 

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