<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.4 20241031//EN"
        "https://jats.nlm.nih.gov/publishing/1.4/JATS-journalpublishing1-4.dtd">
<article  article-type="case-report"        dtd-version="1.4">
            <front>

                <journal-meta>
                                                                <journal-id>thdd</journal-id>
            <journal-title-group>
                                                                                    <journal-title>Türk Hemşireler Derneği Dergisi</journal-title>
            </journal-title-group>
                            <issn pub-type="ppub">2717-9486</issn>
                                                                                                        <publisher>
                    <publisher-name>Türk Hemşireler Derneği</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id pub-id-type="doi">10.70479/thdd.1790749</article-id>
                                                                <article-categories>
                                            <subj-group  xml:lang="en">
                                                            <subject>​Internal Diseases Nursing​</subject>
                                                    </subj-group>
                                            <subj-group  xml:lang="tr">
                                                            <subject>Dahili Hastalıklar Hemşireliği</subject>
                                                    </subj-group>
                                    </article-categories>
                                                                                                                                                        <title-group>
                                                                                                                        <article-title>Kolonoskopi Hazırlığında Su İntoksikasyonu ve Hiponatremi Kaynaklı Epileptik Atak Vaka Serileri İncelemesi: Hemşirelik Bakımı ve Yönetiminde Kritik Noktalar</article-title>
                                                                                                                                                                                                <trans-title-group xml:lang="en">
                                    <trans-title>Case Series Review of Epileptic Seizures Caused by Water Intoxication and Hyponatremia During Colonoscopy Preparation: Critical Points in Nursing Care and</trans-title>
                                </trans-title-group>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0003-3908-3846</contrib-id>
                                                                <name>
                                    <surname>Kapucu</surname>
                                    <given-names>Sevgisun</given-names>
                                </name>
                                                                    <aff>HACETTEPE ÜNİVERSİTESİ, HEMŞİRELİK FAKÜLTESİ</aff>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20260427">
                    <day>04</day>
                    <month>27</month>
                    <year>2026</year>
                </pub-date>
                                        <volume>7</volume>
                                        <issue>1</issue>
                                        <fpage>69</fpage>
                                        <lpage>80</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20250925">
                        <day>09</day>
                        <month>25</month>
                        <year>2025</year>
                    </date>
                                                    <date date-type="accepted" iso-8601-date="20260303">
                        <day>03</day>
                        <month>03</month>
                        <year>2026</year>
                    </date>
                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 2020, Türk Hemşireler Derneği Dergisi</copyright-statement>
                    <copyright-year>2020</copyright-year>
                    <copyright-holder>Türk Hemşireler Derneği Dergisi</copyright-holder>
                </permissions>
            
                                                                                                <abstract><p>Kolonoskopi öncesi bağırsak hazırlığı çoğunlukla güvenli olmakla birlikte, özellikle aşırı sıvı alımı ve eşlik eden ilaç kullanımı elektrolit dengesizliklerine yol açabilmektedir. Bu literatür bazlı vaka serileri incelemesi, polietilen glikol (PEG) bazlı bağırsak hazırlığı sonrasında görülen hiponatremi ve buna bağlı epileptik nöbet gelişimini hemşirelik bakım ve yönetimi açısından değerlendirmeyi amaçlamaktadır. Bu derlemede, polietilen glikol (PEG) bazlı bağırsak hazırlığı sonrası gelişen şiddetli hiponatremi ve epileptik nöbet olguları, hemşirelik bakım perspektifinden sunulmaktadır. Olgu 1: Yetmiş iki yaşında erkek hastada, split-dose PEG sonrası aşırı sıvı tüketimi ve desmopressin kullanımı ile birlikte Na: 112 mEq/L’ye düşen hiponatremi ve jeneralize tonik-klonik nöbet gelişmiş, hipertonik salin tedavisi ile semptomlar düzelmiştir. Olgu 2: Yetmiş beş yaşında kadın hasta, 4 L PEG ve eşlik eden tiazid diüretik uygulaması sonrası benzer şekilde hiponatremi (Na: 112 mEq/L) ve nöbet geçirmiş, uygun tedavi ile semptomlar tamamen gerilemiştir. Olgu 3: Doksan bir yaşında kadın hasta, PEG sonrası hiponatremi (Na: 115 mEq/L) ve nöbet tablosu ile başvurmuş, sıvı-elektrolit tedavisi sonrası klinik düzelme sağlanmıştır. Ortak bulgu, PEG kullanımını takiben şiddetli hiponatremi gelişmesi ile birlikte epileptik nöbet ortaya çıkmasıdır. Tüm olgularda erken tanı ve uygun tedavi ve bakım ile iyileşme sağlanmıştır. Sonuç olarak, hemşirelik bakımında sıvı alımının kontrolü, riskli ilaçların değerlendirilmesi, yaşlı ve komorbid hastaların yakın takibi ile elektrolit bozukluklarının erken fark edilmesi hasta güvenliği açısından kritik öneme sahiptir.</p></abstract>
                                                                                                                                    <trans-abstract xml:lang="en">
                            <p>Although bowel preparation prior to colonoscopy is generally safe, excessive fluid intake and concomitant medication use can lead to electrolyte imbalances. This literature-based case series review aims to evaluate hyponatremia and the development of associated epileptic seizures following polyethylene glycol (PEG)-based bowel preparation from a nursing care and management perspective. This literature review presents cases of severe hyponatremia and epileptic seizures following polyethylene glycol (PEG)-based bowel preparation from a nursing care perspective. Case 1: A 72-year-old male patient developed hyponatremia (Na: 112 mEq/L) and generalized tonic-clonic seizures following excessive fluid consumption and desmopressin use after split-dose PEG; symptoms resolved with hypertonic saline treatment. Case 2: A 75-year-old female patient experienced similar hyponatremia (Na: 112 mEq/L) and seizures after 4 L of PEG and concomitant thiazide diuretic administration; symptoms completely resolved with appropriate treatment. Case 3: A 91-year-old female patient presented with hyponatremia (Na: 115 mEq/L) and seizures following PEG administration. Clinical improvement was achieved after fluid and electrolyte therapy. The common finding is the development of severe hyponatremia following PEG administration, accompanied by epileptic seizures. In all cases, recovery was achieved with early diagnosis and appropriate treatment and care. In conclusion, controlling fluid intake in nursing care, evaluating high-risk medications, closely monitoring elderly and comorbide patients, and early detection of electrolyte imbalances are critical for patient safety.</p></trans-abstract>
                                                            
            
                                                            <kwd-group>
                                                    <kwd>Jeneralize nöbetler</kwd>
                                                    <kwd>  hemşirelik bakımı</kwd>
                                                    <kwd>  bakımı</kwd>
                                                    <kwd>  kolonoskopi</kwd>
                                            </kwd-group>
                                                        
                                                                            <kwd-group xml:lang="en">
                                                    <kwd>Colonoscopy</kwd>
                                                    <kwd>  convulsive seizure</kwd>
                                                    <kwd>  hyponatremia</kwd>
                                                    <kwd>  nursing care</kwd>
                                            </kwd-group>
                                                                                                            </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">1.	Rex DK, Boland CR, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, et al. Colorectal cancer screening: Recommendations for physicians and patients from the U.S. Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2021;161(4):1125-45.</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">2.	Lieberman D, Rex DK, Winawer SJ, Giardiello FM, Johnson DA, Levin TR. Guidelines for colonoscopy surveillance after screening and polypectomy. Gastroenterology. 2016;150(3):785–93.</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">3.	Johnson DA, Barkun AN, Cohen LB, Dominitz JA, Kaltenbach T, Martel M, ve ark. Optimizing adequacy of bowel cleansing for colonoscopy: Recommendations from the US Multi-Society Task Force on Colorectal Cancer. Am J Gastroenterol. 2014;109(10):1528–45.</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">4.	ASGE Standards of Practice Committee, Saltzman JR, Cash BD, Pasha SF, Early DS, Muthusamy VR, ve ark. Bowel preparation before colonoscopy. Gastrointest Endosc. 2015;81(4):781–94.</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">5.	Hookey LC, Vanner S. A review of current issues underlying colon cleansing before colonoscopy. Can J Gastroenterol Hepatol. 2017;2017:8949454.</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">6.	Markowitz GS, Nasr SH, Klein P, Kim DH. Drug-induced electrolyte disorders. N Engl J Med. 2020;382(19):1831-43.</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">7.	Verbalis JG, Goldsmith SR, Greenberg A, Korzelius C, Schrier RW, Sterns RH. Hyponatremia treatment guidelines 2013: Expert panel recommendations. Am J Med. 2013;126(10 Suppl 1):S1-42.</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">8.	Chiang T-H, Tan J-H, Chang C-C, Fang K-C. Seizure from water intoxication following bowel preparation: a case report. BMC Nephrol. 2022;23:271.</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">9.	Lee MH, Lee BH, Oh SK, Seo JY, Kim HJ, Seo BJ. Acute severe hyponatremia with seizure following polyethylene glycol-based bowel preparation for colonoscopy. Kosin Med J. 2012;27(2):173-6.</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">10.	Seyrafian S, Sebghatollahi V, Bastani B. Hyponatremia-induced generalized seizure after taking polyethylene glycol for colon preparation: A case report and brief review of the literature. Clin Case Rep. 2022;10(8):e6247.</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">11.	Khurana A, Singhal S, Sabharwal BD. Hyponatremia after bowel preparation: A case series and review of literature. J Dig Endosc. 2019;10(3):173-7.</mixed-citation>
                    </ref>
                                    <ref id="ref12">
                        <label>12</label>
                        <mixed-citation publication-type="journal">12.	American Society for Gastrointestinal Endoscopy (ASGE). Guideline on bowel preparation before colonoscopy. Gastrointest Endosc. 2021;93(2):437-58.</mixed-citation>
                    </ref>
                                    <ref id="ref13">
                        <label>13</label>
                        <mixed-citation publication-type="journal">13.	Day LW, Kwon A, Inadomi JM, Walter LC, Somsouk M. Adverse events in older patients undergoing colonoscopy: a systematic review and meta-analysis. Gastrointest Endosc. 2011;74(4):885–896.</mixed-citation>
                    </ref>
                                    <ref id="ref14">
                        <label>14</label>
                        <mixed-citation publication-type="journal">14.	Hassan C, Bretthauer M, Kaminski MF, Polkowski M, Rembacken B, Saunders B, et al. Bowel preparation for colonoscopy: European Society of Gastrointestinal Endoscopy (ESGE) guideline. Endoscopy. 2013;45(2):142–50.</mixed-citation>
                    </ref>
                                    <ref id="ref15">
                        <label>15</label>
                        <mixed-citation publication-type="journal">15.	Gupta S, Wang A, Akinnusi M, Pandit V. Hyponatremia in the elderly: challenges and management. Clin Interv Aging. 2020;15:205–15.</mixed-citation>
                    </ref>
                                    <ref id="ref16">
                        <label>16</label>
                        <mixed-citation publication-type="journal">16.	Hobson P, Foy A. The role of nurses in safe bowel preparation: hydration, electrolyte monitoring, and patient education. Gastroenterol Nurs. 2019;42(1):45–53.</mixed-citation>
                    </ref>
                                    <ref id="ref17">
                        <label>17</label>
                        <mixed-citation publication-type="journal">17.	Sharara AI, Abou Fadel C, Biggs D, Waye JD. Predictors of inadequate bowel preparation for colonoscopy. Am J Gastroenterol. 2016;111(4):542–9.</mixed-citation>
                    </ref>
                                    <ref id="ref18">
                        <label>18</label>
                        <mixed-citation publication-type="journal">18.	Miller JL, Btaiche IF. Electrolyte and fluid disturbances in older adults. J Gerontol Nurs. 2019;45(6):21–30.</mixed-citation>
                    </ref>
                                    <ref id="ref19">
                        <label>19</label>
                        <mixed-citation publication-type="journal">19.	Askarian M, Yazdanpanah A, Khorasani-Zavareh D. Nursing responsibilities and patient safety during colonoscopy preparation: A systematic review. J Patient Saf. 2021;17(8):e1525–32.</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
