DESIGN AND SIMULATION OF A NOVEL C-DEP MICROFLUIDICS FOR SINGLE CELL TRAPPING

Year 2017, , 1319 - 1327, 21.07.2017

M.moghimi Zand

https://doi.org/10.18186/journal-of-thermal-engineering.330181

Abstract

Dielectrophoresis (DEP), as
a promising tool, have been used to separate, sort and deform bio-particles. In
traditional method of DEP, the direct contact of electrodes with bio-particles
leads to contamination and lysis of cells and joule heating in medium. In new
DEP methods, such as isolated DEP (iDEP) or contactless DEP (cDEP), some of
these rigors are overcame. In the method presented herein, these new techniques
are used to provide a non-uniform electric field to trap a single cell in a
desired area. We used the insulating structures to guide a flow as well as the
manipulation of particles. Finite element analysis (FEA) is used to obtain an
optimized microstructure. The joule heating and maximum DEP force is compared
with traditional method and results prove the capability of these systems to
trap a single cell efficiently.

Keywords

Single Cell Trapping, DEP, CDEP, Microfluidics, FEM, Joule Heating

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