CHANGES AND DISEASES OF THE KIDNEY IN OLD AGE

Yıl 2025, Cilt: 2 Sayı: 3, 41 - 49, 20.03.2025

Emre Demirel , Gökçe Bağcı Uzun , Muhammed Furkan Arpacı , Hıdır Pekmez

https://doi.org/10.5281/zenodo.15056247

Öz

Yaşlanma, böbrekler de dâhil olmak üzere tüm organları etkileyen kaçınılmaz bir biyolojik süreçtir. Bu derlemenin amacı, yaşlanma sürecinde böbreklerde meydana gelen yapısal ve fonksiyonel değişiklikleri ve bu değişikliklerin klinik yansımalarını incelemektir. Yaşlı nüfusta kronik böbrek hastalığının prevalansı yüksektir ve bu durum, diyabet ve hipertansiyon gibi ek koşulların etkisiyle böbrek hasarına yatkınlığı artırmaktadır. Yaşlanmanın böbrek fonksiyonları üzerindeki etkilerini anlamak, yaşlı hastalarda böbrek hastalıklarının tanısı, tedavisi ve yaşam kalitesinin iyileştirilmesi açısından kritik öneme sahiptir. Ayrıca, yaşa bağlı böbrek değişiklikleri ve bu değişikliklerin sağlık sonuçları üzerine rehberlik sağlayacak bilgiler sunmaktır.

Anahtar Kelimeler

Aging, Kidney, Kidney Function, Kidney Anatomy, Kidney Diseases

Kaynakça

• Referans1 Hansberry, M. R., Whittier, W. L., & Krause, M. W. (2005). The elderly patient with chronic kidney disease. Advances in chronic kidney disease, 12(1), 71-77.
• Referans2 Beğer, T., & Yavuzer, H. (2012). Yaşlılık ve yaşlılık epidemiyolojisi. Klinik gelişim, 25(3), 1-3.
• Referans3 Ma LJ, Fogo AB: Model of robust induction of glomerulosclerosis in mice: Importance of genetic background. Kidney Int 2003; 64: 350-355.
• Referans4 Soranno, Danielle E., et al. "The Role of Sex and Gender in Acute Kidney Injury-Consensus Statements from the 33rd Acute Disease Quality Initiative." Kidney International (2025).
• Referans5 Harvey, Brian J.; Alvarez De La Rosa, Diego. Sex Differences in Kidney Health and Disease. Nephron, 2025, 149.2: 77-103.
• Referans6 Maric C, Sandberg K, Hinojosa-Laborde C: Glomerulosclerosis and tubulo-interstitial fibrosis are attenuated with 17 beta-estradiol in the aging Dahl salt sensitive rat. J Am Soc Nephrol 2004; 15 (6): 1546-1556
• Referans7 Negri AL: The klotho gene: A gene predominantly expressed in the kidney is a fundamental regulator of aging and calcium/phosphorus metabolism. J Nephrol 2005; 18 (6): 654-658
• Referans8 Marcantoni C, Li-Jun M, Federspiel C, Fogo A: Hypertensive nephrosclerosis in African Americans versus Caucasians. Kidney Int 2002; 62 (1): 172-180
• Referans9 Denıc, Aleksandar; Glassock, Richard J.; Rule, Andrew D. Structural and functional changes with the aging kidney. Advances in chronic kidney disease, 2016, 23. 1: 19-28.
• Referans10 Glassock, Richard J., and Andrew D. Rule. "The implications of anatomical and functional changes of the aging kidney: with an emphasis on the glomeruli." Kidney international 82.3 , 2012: 270-277.
• Referans11 Caramori, M. Luiza, John M. Basgen, and Michael Mauer. "Glomerular structure in the normal human kidney: differences between living and cadaver donors." Journal of the American Society of Nephrology 14.7 , 2003: 1901-1903.
• Referans12 Kaplan C, Pastemack B, Shah H, Gallo G: Age-related incidence of sclerotic glomeruli in human kidneys. Am J Pathol 1975; 80:227-234.
• Referans13 Kappel B, Olsen S: Cortical interstitial tissue and sclerosed glomeruli in the normal human kidney, related to age and sex. A quantitative study. Virchows Arch A 1980; 387:271-277.
• Referans14 Xıa, Tian, Et Al. Vascular endothelial cell injury: causes, molecular mechanisms, and treatments. MedComm, 2025, 6.2: e70057.
• Referans15 Bolıgnano, Davide, et al. The aging kidney revisited: a systematic review. Ageing research reviews, 2014, 14: 65-80.
• Referans16 Takazakura E. Sawabu N, Handa A: Intrarenal vascular changes with age and disease. Kidney Int 1972; 2:224-230.
• Referans17 Martin JE, Sheaff MT: Renal ageing. J Pathol 2007; 211: 198-205
• Referans18 Davies D, Shock N: Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. J Clin Invest 1950; 29:496-507.
• Referans19 Hollenberg N, Adams D, Solomon H; Senescence and the renal vasculature in normal man. Circ Res 1974; 34:309-316.
• Referans20 O’sullıvan, Eoin D.; Hughes, Jeremy; Ferenbach, David A. Renal aging: causes and consequences. Journal of the American Society of Nephrology, 2017, 28.2: 407-420.
• Referans21 Verhave, Jacobien C., et al. Estimation of renal function in subjects with normal serum creatinine levels: influence of age and body mass index. American Journal of Kidney Diseases, 2005, 46.2: 233-241.
• Referans22 Luft F. Fineberg N, Miller J; The effects of age, race, and heredity on glomerular filtration rate following volume expansion and contraction in normal man. Am J Med Sci 1980; 279:15-24.
• Referans23 Corman B. Roinel N: Single nephron function rate and proximal tubular reabsorption in aging rats. Am J Physiol 1991; 260:F75-F80.
• Referans24 Fehrman‐Ekholm, Ingela; Skeppholm, Lars. Renal function in the elderly (> 70 years old) measured by means of iohexol clearance, serum creatinine, serum urea and estimated clearance. Scandinavian journal of urology and nephrology, 2004, 38.1: 73-77.
• Referans25 Rodgers H, Staniland JR. Lipkin GW, Turney JH: Acute renal failure; A study of elderly patients. Age Ageing 1990; 19:36,42.
• Referans26 Vavılala, Pratyusha; Narayanasamy, Nandita. Water Nutriture: Essential but Misunderstood. Current Nutrition & Food Science, 2025, 21.1: 2-13.,
• Referans27 Tank JE, Vora JP, Houghton DC, Anderson S: Altered renal vascular responses in the aging rat kidney. Am J Physiol 1994; 266 (6 Pt 2): 942-948
• Referans28 Richard J Johnson, John Feehally: Comprehensive Clinical Nephrology (2nd). Mosby, 2003; 835-841
• Referans29 Schlondorff, Detlef O. "Overview of factors contributing to the pathophysiology of progressive renal disease." Kidney international 74.7: 2008: 860-866.
• Referans30 Baylis C, Corman B: The aging kidney: Insights from experimental studies. J Am Soc Nephrol 1998; 9 (4): 699-709
• Referans31 Coresh J, Astor BC, Greene T, Eknoyan G, Levey AS: Prevalence of chronic kidney disease and decreased kidney function in the adult US population. Third National Health and Nutrition Examination Survey. Am J Kidney Dis 2003; 41: 1-12
• Referans32 Glassock RJ: Glomerular disease in t he elderly population. In Oreopoulos DG, Hazzard WR, Luke R (eds): Nephrology and Geriatrics Integrated. Dordrecht, Kluwer Academic Publishers, 2000; 57-66
• Referans33 Vendemia F, Gesualdo L, Schena FP, D’Amico G; Renal Immunopathology Study Group of the Italian Society of Nephrology; Epidemiology of primary glomerulonephritis in the elderly. Report from the Italian Registry of Renal Biopsy. J Nephrol 2001; 14 (5): 340-352
• Referans34 Vassallo M, Shepherd RJ, Iqbal P, Feehally I: Age-related variations in presentation and outcome in Wegener’s granulomatosis. J R Coll Physicians Lond 1997; 31 (4): 396-400
• Referans35 Ronco, Pierre, et al. "Membranous nephropathy." Nature reviews Disease primers 2021; 69: 7.1
• Referans36 Wiggins J: Geriatrics. Am J Kidney Dis 2005; 46 (1): 147-158
• Referans37 Pascual J, Liano F, Ortuno J: The elderly patient with acute renal failure. J Am Soc Nephrol 1995; 6: 144-153
• Referans38 Nair, Ramesh, Jane M. Bell, and Patrick D. Walker. "Renal biopsy in patients aged 80 years and older." American journal of kidney diseases  2004; 44.4: 618-626.
• Referans39 Haas M, Spargo BH, Wit EJ, Meehan SM: Etiologies and outcome of acute renal insufficiency in older adults: A renal biopsy study of 259 cases. Am J Kidney Dis 2000; 35: 433-447
• Referans40 Davison AM: Renal disease in the elderly. Nephron 1998; 80: 6-16