Drug Eruptions with Cases: Fixed Drug Eruption and DRESS Syndrome

Year 2022, , 130 - 133, 01.04.2022

Şeyma Handan Akyön , Yeşer Genç

https://doi.org/10.46310/tjim.1066277

Abstract

Cutaneous drug reactions usually occur with mild and self-limiting lesions, but severe forms can be life-threatening. Non-steroidal anti-inflammatory drugs, antibiotics, and anticonvulsants often cause drug reactions. Herein, we presented two cases of immunological drug reaction, one with mild and localized fixed drug eruption and the other with more severe and diffuse DRESS syndrome.

Keywords

drug eruptions, skin, side effect, adverse reaction

References

• A Riedl M, Casillas A. Adverse drug reactions: types and treatment options. Am Fam Physician. 2003 Nov 1;68(9):1781-90.
• Roujeau J, Stern R. Severe adverse cutaneous reactions to drugs. N Engl J Med. 1994 Nov 10;331(19):1272-85. doi: 10.1056/NEJM199411103311906.
• Executive summary of disease management of drug hypersensitivity: a practice parameter. Joint Task Force on Practice Parameters, the American Academy of Allergy, Asthma and Immunology, and the Joint Council of Allergy, Asthma and Immunology. Ann Allergy Asthma Immunol. 1999 Dec;83(6 Pt 3):665-700.
• Hertl M, Merk H. Lymphocyte activation in cutaneous drug reactionsJ Invest Dermatol. 1995 Jul;105(1 Suppl):95S-98S. doi: 10.1038/jid.1995.19.
• NayakS,AcharjyaB.Adversecutaneousdrugreaction.IndianJ Dermatol. 2008 Jan;53(1):2-8. doi: 10.4103/0019-5154.39732.
• Marzano AV, Borghi A, Cugno M. Adverse drug reactions and organ damage: The skin. Eur J Intern Med. 2016 Mar;28:17-24. doi: 10.1016/j.ejim.2015.11.017.
• Bigby M. Rates of cutaneous reactions to drugs. Arch Dermatol. 2001 Jun;137(6):765-70.
• McKenna JK, Leiferman KM. Dermatologic drug reactions. Immunol Allergy Clin North Am. 2004 Aug;24(3):399-423, vi. doi: 10.1016/j.iac.2004.03.007.
• Breathnach SM. Drug reactions. In: Burns T, Breathnach S, Cox N, Griffiths C, eds. Rook’s Textbook of Dermatology. 8th ed. Oxford: Blackwell Science; 2010:28-177.
• Pai V, Bhandari P, Kikkeri N, Athanikar S, Sori T. Fixed drug eruption to fluconazole: A case report and review of literature. Indian J Pharmacol. Sep-Oct 2012;44(5):643-5. doi: 10.4103/0253- 7613.100403.
• Brahimi N, Routier E, Raison-Peyron N, Tronquoy AF, Pouget- Jasson C, Amarger S, Machet L, Amsler E, Claeys A, Sassolas B, Leroy D, Grange A, Dupuy A, Cordel N, Bonnetblanc JM, Milpied B, Doutre MS, Guinnepain MT, Barbaud A, Chosidow O, Roujeau JC, Lebrun-Vignes B, Descamps V. A three-year- analysis of fixed drug eruptions in hospital settings in France. Eur J Dermatol. 2010 Jul-Aug;20(4):461-4. doi: 10.1684/ ejd.2010.0980.
• Tetsuo S. Fixed drug eruption. UpToDate. Published online 2021. Avaliable at: https://www.uptodate.com/contents/fixed-drug- eruption. Accessed January, 2022.
• Criado PR. Adverse drug reactions. In: Bonamigo RR, Dornelles SIT, eds. Dermatology in Public Health Environments: A Comprehensive Textbook. Springer International Publishing; 2016 Dec 31:519-76. doi: 10.1007/978-3-319-33919-1_26.
• Lee HY. Drug reaction with eosinophilia and systemic symptoms (DRESS). Uptodate. Published online 2021. Avaliable at: https:// www.uptodate.com/contents/drug-reaction-with-eosinophilia- and-systemic-symptoms-dress. Accessed January, 2022.
• Emre S, Akoǧlu G, Metin A, Demirseren DD, Kurtoǧlu G. Evaluation of clinical features of 11 cases with DRESS syndrome. Turkderm-Archives of the Turkish Dermatology and Venerology. 2013;47(4):218-22 (in Turkish). doi: 10.4274/turkderm.71324.
• Kardaun SH, Sidoroff A, Valeyrie-Allanore L, Halevy S, Davidovici BB, Mockenhaupt M, Roujeau JC. Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? Br J Dermatol. 2007 Mar;156(3):609-11. doi: 10.1111/j.1365-2133.2006.07704.x.