Evaluation of the relationship between dehydroepiandrosterone sulfate-total testosterone ratio and metabolic parameters in patients with polycystic ovary syndrome

Year 2022, , 47 - 54, 01.04.2022

Özen Öz Gül , Soner Cander

https://doi.org/10.46310/tjim.1070164

Abstract

Objective: In this study we aimed to evaluate the correlations between dehydroepiandrosterone sulfate-total testosterone (DHEAS/TT) ratio and insulin resistance, glycemic and lipid parameters.
Methods: A total of 35 patients with polycystic ovary syndrome (PCOS) and 34 healthy volunteers were included in the study. Anthropometric, clinical, biochemical, lipid and glycemic measurements were performed according to routine standards. Patients’ demographic, clinical, anthropometric, biochemical, glycemic, lipid and hormonal parameters were measured and recorded. DHEAS/TT ratio was calculated in all patients. DHEAS/TT ratio and metabolic parameters were compared between the PCOS and control groups.
Results: There were significant differences between the PCOS and control groups in terms of fasting blood glucose, total cholesterol, high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), triglycerides, insulin and homeostatic model assessment-Insulin resistance (HOMA-IR) values (for all, p<0.05). Androstenedione and DHEAS/TT values were statistically significantly higher in the PCOS group. Pearson’s correlation analysis revealed no statistically significant correlation between DHEAS/TT ratio and body mass index (BMI), HOMA-IR and lipid profile.
Conclusion: In PCOS patients, glycemic and lipid parameters, HOMA-IR and DHEAS levels were significantly higher compared to the control subjects. In addition, the DHEAS/TT ratio was also significantly higher at limit in the PCOS group. However, no correlations were observed between DHEAS/TT ratio, BMI, glycemic and lipid parameters, suggesting that DHEAS/TT ratio is not an appropriate method to be used in prediction of metabolic status in patients with PCOS.

Keywords

Polycystic ovary syndrome, lipid profile, dehydroepiandrosterone sulfate testosterone, insulin resistance, body mass index

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