Evaluation of sitagliptin therapy on the levels of fibroblast growth factor-19 (FGF19) in patients with Type 2 diabetes

Abstract

Introduction: The specific association between sitagliptin and Fibroblast Growth Factor-19 (FGF19) is yet to be clarified. In this study, we aimed to investigate the effect of sitagliptin therapy on the levels of FDF19 in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 35 patients newly diagnosed type 2 diabetes, and who had not received antidiabetic treatment before were included in this study. Sitagliptin therapy was administered as 100 mg/day. Patients’ demographic, anthropometric features, glycaemic variables, lipid profiles and FGF19 values were evaluated at the baseline and at the 3rd month of the treatment and the obtained data were compared. Results: The mean age of the patients was 53.34 ± 8.09 years. The mean weight, body mass index (BMI), hip circumference, postprandial blood glucose and glycosylated haemoglobin A1c (HbA1c) values were statistically significantly lower at the 3rd month of the treatment compared to the baseline values (for all, p<0.05). The mean FGF19 was found as 84.37±64.23 pg/mL at the baseline and 86.06±44.10 pg/mL at the 3rd month of the treatment and the difference was not statistically significant (p=0.789). A moderate negative correlation was found between FGF19, total cholesterol and low density lipoprotein cholesterol (LDL-c), and a moderate positive correlation between FGF19 and triglycerides. Conclusion: This study did not show a significant effect of sitagliptin therapy on FGF19. T2DM variables such as postprandial blood glucose and HbAc1 were significantly improved. FGF19 was moderately correlated with total cholesterol and LDL-c in negative direction and with triglycerides in positive direction.

Keywords

• Type 2 diabetes mellitus
• fibroblast growth factor-19
• sitagliptin
• hyperglycemia
• blood glucose

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