Case Report

Indomethacin induced toxic hepatitis: a case report

Volume: 4 April 1, 2022
EN

Indomethacin induced toxic hepatitis: a case report

Abstract

Nonsteroidal anti-inflammatory drugs deare widely used worldwide for analgesic, antipyretic and anti-inflammatory purposes. Indomethacin is a potent nonsteroidal anti-inflammatory drug and can cause severe liver damage. Few cases of idiosyncratic toxic hepatitis have been reported. Here, we present a case of indomethacin-induced toxic hepatitis that improved with methylprednisolone treatment.

Keywords

Supporting Institution

Bursa Uludag University Faculty of Medicine

Thanks

We thank our patient for allowing her data to be used in this scientific study.

References

  1. Huskisson EC, Taylor RT, Burston D, Chuter PJ, Hart FD. Evening indomethacin in the treatment of rheumatoid arthritis. Ann Rheum Dis. 1970 Jul;29(4):393-6. doi: 10.1136/ard.29.4.393.
  2. Carson JL, Strom BL, Duff A, Gupta A, Das K. Safety of nonsteroidal anti-inflammatory drugs with respect to acute liver disease. Arch Intern Med. 1993 Jun 14;153(11):1331-6.
  3. Cappell MS, Kozicky O, Competiello LS. Indomethacin- associated cholestasis. J Clin Gastroenterol. 1988 Aug;10(4):445- 7. doi: 10.1097/00004836-198808000-00019.
  4. Kelsey WM, Scharyj M. Fatal hepatitis probably due to indomethacin. JAMA. 1967 Feb 20;199(8):586-7. Fenech FF, Bannister WH, Grech JL. Hepatitis with biliverdinaemia in association with indomethacin therapy. Br Med J. 1967 Jul 15;3(5558):155-6. doi: 10.1136/bmj.3.5558.155.
  5. de Kraker-Sangster M, Bronkhorst FB, Brandt KH, Boersma JW. Massive liver cell necrosis following administration of indomethacin in combination with aminophenzone. Ned Tijdschr Geneeskd. 1981 Nov 7;125(45):1828-31 (in Dutch).
  6. Opolon P, Cartron J, Chicot D, Caroli J. Application of the lymphoblastic transformation test (LTT) to the diagnosis of drug-induced hepatitis. Presse Med. 1969 Dec 20;77(54):2041-4 (in French).
  7. Arıcı S. Toksik Hepatit. Pamukkale Tıp Dergisi. 2008;1(2):113-9.
  8. Castaldo ET, Chari RS. Liver transplantation for acute hepatic failure. HPB (Oxford). 2006;8(1):29-34. doi: 10.1080/13651820500465741.

Details

Primary Language

English

Subjects

​Internal Diseases

Journal Section

Case Report

Publication Date

April 1, 2022

Submission Date

February 15, 2022

Acceptance Date

March 9, 2022

Published in Issue

Year 1970 Volume: 4

APA
Sakar, O., Teker, T., Nak, S. G., & Uğraş, N. (2022). Indomethacin induced toxic hepatitis: a case report. Turkish Journal of Internal Medicine, 4, 139-142. https://doi.org/10.46310/tjim.1072846
AMA
1.Sakar O, Teker T, Nak SG, Uğraş N. Indomethacin induced toxic hepatitis: a case report. Turk J Int Med. 2022;4:139-142. doi:10.46310/tjim.1072846
Chicago
Sakar, Orkun, Tufan Teker, Selim Giray Nak, and Nesrin Uğraş. 2022. “Indomethacin Induced Toxic Hepatitis: A Case Report”. Turkish Journal of Internal Medicine 4 (April): 139-42. https://doi.org/10.46310/tjim.1072846.
EndNote
Sakar O, Teker T, Nak SG, Uğraş N (April 1, 2022) Indomethacin induced toxic hepatitis: a case report. Turkish Journal of Internal Medicine 4 139–142.
IEEE
[1]O. Sakar, T. Teker, S. G. Nak, and N. Uğraş, “Indomethacin induced toxic hepatitis: a case report”, Turk J Int Med, vol. 4, pp. 139–142, Apr. 2022, doi: 10.46310/tjim.1072846.
ISNAD
Sakar, Orkun - Teker, Tufan - Nak, Selim Giray - Uğraş, Nesrin. “Indomethacin Induced Toxic Hepatitis: A Case Report”. Turkish Journal of Internal Medicine 4 (April 1, 2022): 139-142. https://doi.org/10.46310/tjim.1072846.
JAMA
1.Sakar O, Teker T, Nak SG, Uğraş N. Indomethacin induced toxic hepatitis: a case report. Turk J Int Med. 2022;4:139–142.
MLA
Sakar, Orkun, et al. “Indomethacin Induced Toxic Hepatitis: A Case Report”. Turkish Journal of Internal Medicine, vol. 4, Apr. 2022, pp. 139-42, doi:10.46310/tjim.1072846.
Vancouver
1.Orkun Sakar, Tufan Teker, Selim Giray Nak, Nesrin Uğraş. Indomethacin induced toxic hepatitis: a case report. Turk J Int Med. 2022 Apr. 1;4:139-42. doi:10.46310/tjim.1072846

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