Adult Onset Still’s Disease is a rare systemic inflammatory disease. The absence of a specific clinical presentation and diagnostic biomarkers causes delays in diagnosing and treating AOSD. Steroids used in treatment have many undesirable side effects. We presented a female case with AOSD who developed sudden bradycardia after pulse steroid therapy.
Gerfaud-Valentin M, Jamilloux Y, Iwaz J, Sève P. Adult-onset Still’s disease. Autoimmun Rev. 2014 Jul;13(7):708-22. doi: 10.1016/j.autrev.2014.01.058.
Kundu A, Fitzgibbons TP. Acute symptomatic sinus bradycardia in a woman treated with pulse dose steroids for multiple sclerosis: a case report. J Med Case Rep. 2015 Sep 24;9:216. doi: 10.1186/ s13256-015-0701-x.
Vasheghani-Farahani A, Sahraian MA, Darabi L, Aghsaie A, Minagar A. Incidence of various cardiac arrhythmias and conduction disturbances due to high dose intravenous methylprednisolone in patients with multiple sclerosis. J Neurol Sci. 2011 Oct 15;309(1-2):75-8. doi: 10.1016/j.jns.2011.07.018.
Khandelwal K, Madathala RR, Chennaiahgari N, Yousuffuddin M. Steroid-induced sinus bradycardia. Cureus. 2021 May 16;13(5):e15065. doi: 10.7759/cureus.15065.
Üsküdar Cansu D, Bodakçi E, Korkmaz C. Dose-dependent bradycardia as a rare side effect of corticosteroids: a case report and review of the literature. Rheumatol Int. 2018 Dec;38(12):2337- 2343. doi: 10.1007/s00296-018-4167-1.
Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, Janecek E, Domecq C, Greenblatt DJ. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981 Aug;30(2):239-45. doi: 10.1038/clpt.1981.154.
Guillén EL, Ruíz AM, Bugallo JB. Hypotension, bradycardia, and asystole after high-dose intravenous methylprednisolone in a monitored patient. Am J Kidney Dis. 1998 Jul;32(2):E4. doi: 10.1053/ajkd.1998.v32.pm10074612.
Gerfaud-Valentin M, Jamilloux Y, Iwaz J, Sève P. Adult-onset Still’s disease. Autoimmun Rev. 2014 Jul;13(7):708-22. doi: 10.1016/j.autrev.2014.01.058.
Kundu A, Fitzgibbons TP. Acute symptomatic sinus bradycardia in a woman treated with pulse dose steroids for multiple sclerosis: a case report. J Med Case Rep. 2015 Sep 24;9:216. doi: 10.1186/ s13256-015-0701-x.
Vasheghani-Farahani A, Sahraian MA, Darabi L, Aghsaie A, Minagar A. Incidence of various cardiac arrhythmias and conduction disturbances due to high dose intravenous methylprednisolone in patients with multiple sclerosis. J Neurol Sci. 2011 Oct 15;309(1-2):75-8. doi: 10.1016/j.jns.2011.07.018.
Khandelwal K, Madathala RR, Chennaiahgari N, Yousuffuddin M. Steroid-induced sinus bradycardia. Cureus. 2021 May 16;13(5):e15065. doi: 10.7759/cureus.15065.
Üsküdar Cansu D, Bodakçi E, Korkmaz C. Dose-dependent bradycardia as a rare side effect of corticosteroids: a case report and review of the literature. Rheumatol Int. 2018 Dec;38(12):2337- 2343. doi: 10.1007/s00296-018-4167-1.
Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, Janecek E, Domecq C, Greenblatt DJ. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981 Aug;30(2):239-45. doi: 10.1038/clpt.1981.154.
Guillén EL, Ruíz AM, Bugallo JB. Hypotension, bradycardia, and asystole after high-dose intravenous methylprednisolone in a monitored patient. Am J Kidney Dis. 1998 Jul;32(2):E4. doi: 10.1053/ajkd.1998.v32.pm10074612.
İldemir S, Ercan BN, Ekin A, Coşkun BN, Pehlivan Y, Dalkılıç HE (April 1, 2022) A case of sinus bradycardia in a patient treated with pulse steroids for Adult-onset Still’s Disease. Turkish Journal of Internal Medicine 4 109–112.
Turkish Journal of Internal Medicine, hosted by Turkish JournalPark ACADEMIC, is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.