Thrombotic thrombocytopenic purpura (TTP) is thrombotic microangiopathy caused by decreased activity of ADAMTS13, a von Willebrand factor-degrading metalloprotease. Here, we present a male patient with neurological symptoms, diagnosed with TTP and successfully treated with plasmapheresis.
Chiasakul T, Cuker A. Clinical and laboratory diagnosis of TTP: an integrated approach. Hematology Am Soc Hematol Educ Program. 2018 Nov 30;2018(1):530-8. doi: 10.1182/ asheducation-2018.1.530.
Burns ER, Lou Y, Pathak A. Morphologic diagnosis of thrombotic thrombocytopenic purpura. Am J Hematol. 2004 Jan;75(1):18-21. doi: 10.1002/ajh.10450.
George JN. How I treat patients with thrombotic thrombocytopenic purpura: 2010. Blood. 2010 Nov 18;116(20):4060-9. doi: 10.1182/ blood-2010-07-271445. Epub 2010 Aug 4. Erratum in: Blood. 2011 May 19;117(20):5551.
Page EE, Kremer Hovinga JA, Terrell DR, Vesely SK, George JN. Thrombotic thrombocytopenic purpura: diagnostic criteria, clinical features, and long-term outcomes from 1995 through 2015. Blood Adv. 2017 Apr 6;1(10):590-600. doi: 10.1182/ bloodadvances.2017005124.
Chiasakul T, Cuker A. Clinical and laboratory diagnosis of TTP: an integrated approach. Hematology Am Soc Hematol Educ Program. 2018 Nov 30;2018(1):530-8. doi: 10.1182/ asheducation-2018.1.530.
Burns ER, Lou Y, Pathak A. Morphologic diagnosis of thrombotic thrombocytopenic purpura. Am J Hematol. 2004 Jan;75(1):18-21. doi: 10.1002/ajh.10450.
George JN. How I treat patients with thrombotic thrombocytopenic purpura: 2010. Blood. 2010 Nov 18;116(20):4060-9. doi: 10.1182/ blood-2010-07-271445. Epub 2010 Aug 4. Erratum in: Blood. 2011 May 19;117(20):5551.
Page EE, Kremer Hovinga JA, Terrell DR, Vesely SK, George JN. Thrombotic thrombocytopenic purpura: diagnostic criteria, clinical features, and long-term outcomes from 1995 through 2015. Blood Adv. 2017 Apr 6;1(10):590-600. doi: 10.1182/ bloodadvances.2017005124.
Çakır Y, Orhan B, Ozkocaman V, Özkalemkaş F (April 1, 2022) Thrombocytopenic Thrombotic Pupura Presenting with Neurological Symptoms : A Case Report. Turkish Journal of Internal Medicine 4 164–165.
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