Abstract
Immune checkpoint inhibitors inhibit the inhibitory mechanism on the immune system, their side effects may be autoimmune diseases that occur due to excessive immune response. Pembrolizumab is an immune checkpoint inhibitor targeting PD-1. The most common clinical presentations of thyroid injury induced by pembrolizumab are destructive thyroiditis and overt hypothyroidism. Herein, we presented a case of pembrolizumab induced hypothyroidism.
Keywords
Pembrolizumab immune checkpoint inhibitors lung cancer hypothyroidism PD-1 non-small cell lung
References
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Abstract
References
- Alhamad EH, Cosgrove GP. Interstitial lung disease: the initial approach. Med Clin North Am. 2011 Nov;95(6):1071-93. doi: 10.1016/j.mcna.2011.08.008.
- Parekh M, Donuru A, Balasubramanya R, Kapur S. Review of the chest CT differential diagnosis of ground-glass opacities in the COVID era. Radiology. 2020 Dec;297(3):E289-E302. doi: 10.1148/radiol.2020202504.
- Lee EYP, Ng MY, Khong PL. COVID-19 pneumonia: what has CT taught us? Lancet Infect Dis. 2020 Apr;20(4):384-385. doi: 10.1016/S1473-3099(20)30134-1.
- Matsuno O. Drug-induced interstitial lung disease: mechanisms and best diagnostic approaches. Respir Res. 2012 May 31;13(1):39. doi: 10.1186/1465-9921-13-39.
- Murugan AK. mTOR: Role in cancer, metastasis and drug resistance. Semin Cancer Biol. 2019 Dec;59:92-111. doi: 10.1016/j. semcancer.2019.07.003.
- Leung EY, Askarian-Amiri M, Finlay GJ, Rewcastle GW, Baguley BC. Potentiation of growth inhibitory responses of the mTOR inhibitor everolimus by dual mTORC1/2 inhibitors in cultured breast cancer cell lines. PLoS One. 2015 Jul 6;10(7):e0131400. doi: 10.1371/journal.pone.0131400.
- Lopez P, Kohler S, Dimri S. Interstitial lung disease associated with mTOR inhibitors in solid organ transplant recipients: Results from a large phase iii clinical trial program of everolimus and review of the literature. J Transplant. 2014;2014:305931. doi: 10.1155/2014/305931.
Details
| Primary Language | English |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | Case Reports |
| Authors | |
| Publication Date | April 1, 2022 |
| Submission Date | February 24, 2022 |
| Acceptance Date | March 9, 2022 |
| Published in Issue | Year 2022 |
