Six-Month Changes in Hemogram-Derived Inflammatory Indexes and Glycemic Parameters in Patients with Type 2 Diabetes: A Real-World Retrospective Study

Bilge Özcan; Meryem Ümit Kurban

doi:10.46310/tjim.1893961

Six-Month Changes in Hemogram-Derived Inflammatory Indexes and Glycemic Parameters in Patients with Type 2 Diabetes: A Real-World Retrospective Study

Abstract

Objective: To evaluate six-month changes in hemogram-derived inflammatory indices (neutrophil-tolymphocyte ratio [NLR], systemic immune-inflammation index [SII], systemic inflammation response index [SIRI], and aggregate index of systemic inflammation [AISI]) and their association with glycemic parameters in patients with type 2 diabetes mellitus (T2DM) under routine clinical care.

Methods: This retrospective cohort study analyzed electronic medical records of 183 adults with T2DM from a single center (2022–2023). All patients had paired laboratory measurements approximately six months apart. Primary analysis examined overall changes in glycemic parameters (fasting glucose, HbA1c) and inflammatory indices using Wilcoxon signed-rank tests; correlations were assessed with Spearman’s rho.

Results: Over six months, all four inflammatory indices decreased significantly: NLR (2.14→1.66, p<0.001, r=0.87), SII (593.6→476.0, p<0.001, r=0.74), SIRI (0.88→0.70, p<0.001, r=0.70), and AISI (231.5→188.0, p<0.001, r=0.63). Fasting glucose decreased (125→109 mg/dL, p<0.001, r=0.80), while HbA1c showed a small reduction (7.00%→6.80%, p<0.001, r=0.23). Changes in glycemic parameters correlated poorly with changes in inflammatory indices (all |ρ|<0.20).

Conclusion: Hemogram-derived inflammatory indices improve markedly and consistently in T2DM patients over six months of real-world treatment. These improvements are largely independent of glycemic response, suggesting that NLR, SII, SIRI, and AISI may capture anti-inflammatory effects not reflected by HbA1c. These low-cost, universally available indices may serve as complementary markers in routine T2DM care.

Keywords

Ethical Statement

Clinical Research Ethics Committee of Usak University, No: 293-293-25/2024

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Details

Primary Language

English

Subjects

Internal Diseases, Clinical Sciences (Other)

Journal Section

Research Article

Authors

Bilge Özcan ^*
0000-0001-9255-7057
Türkiye

Meryem Ümit Kurban
0009-0008-3881-361X
Türkiye

Publication Date

April 28, 2026

Submission Date

February 24, 2026

Acceptance Date

April 14, 2026

Published in Issue

Year 2026 Volume: 8

DOI

https://doi.org/10.46310/tjim.1893961

IZ

https://izlik.org/JA35BM35ZW

Cite

RIS / Bibtex

APA

Özcan, B., & Ümit Kurban, M. (2026). Six-Month Changes in Hemogram-Derived Inflammatory Indexes and Glycemic Parameters in Patients with Type 2 Diabetes: A Real-World Retrospective Study. Turkish Journal of Internal Medicine, 8, 74-80. https://doi.org/10.46310/tjim.1893961

AMA

1.Özcan B, Ümit Kurban M. Six-Month Changes in Hemogram-Derived Inflammatory Indexes and Glycemic Parameters in Patients with Type 2 Diabetes: A Real-World Retrospective Study. Turk J Int Med. 2026;8:74-80. doi:10.46310/tjim.1893961

Chicago

Özcan, Bilge, and Meryem Ümit Kurban. 2026. “Six-Month Changes in Hemogram-Derived Inflammatory Indexes and Glycemic Parameters in Patients With Type 2 Diabetes: A Real-World Retrospective Study”. Turkish Journal of Internal Medicine 8 (April): 74-80. https://doi.org/10.46310/tjim.1893961.

EndNote

Özcan B, Ümit Kurban M (April 1, 2026) Six-Month Changes in Hemogram-Derived Inflammatory Indexes and Glycemic Parameters in Patients with Type 2 Diabetes: A Real-World Retrospective Study. Turkish Journal of Internal Medicine 8 74–80.

IEEE

[1]B. Özcan and M. Ümit Kurban, “Six-Month Changes in Hemogram-Derived Inflammatory Indexes and Glycemic Parameters in Patients with Type 2 Diabetes: A Real-World Retrospective Study”, Turk J Int Med, vol. 8, pp. 74–80, Apr. 2026, doi: 10.46310/tjim.1893961.

ISNAD

Özcan, Bilge - Ümit Kurban, Meryem. “Six-Month Changes in Hemogram-Derived Inflammatory Indexes and Glycemic Parameters in Patients With Type 2 Diabetes: A Real-World Retrospective Study”. Turkish Journal of Internal Medicine 8 (April 1, 2026): 74-80. https://doi.org/10.46310/tjim.1893961.

JAMA

1.Özcan B, Ümit Kurban M. Six-Month Changes in Hemogram-Derived Inflammatory Indexes and Glycemic Parameters in Patients with Type 2 Diabetes: A Real-World Retrospective Study. Turk J Int Med. 2026;8:74–80.

MLA

Özcan, Bilge, and Meryem Ümit Kurban. “Six-Month Changes in Hemogram-Derived Inflammatory Indexes and Glycemic Parameters in Patients With Type 2 Diabetes: A Real-World Retrospective Study”. Turkish Journal of Internal Medicine, vol. 8, Apr. 2026, pp. 74-80, doi:10.46310/tjim.1893961.

Vancouver

1.Bilge Özcan, Meryem Ümit Kurban. Six-Month Changes in Hemogram-Derived Inflammatory Indexes and Glycemic Parameters in Patients with Type 2 Diabetes: A Real-World Retrospective Study. Turk J Int Med. 2026 Apr. 1;8:74-80. doi:10.46310/tjim.1893961