Primary Membranous Glomerulonephritis in a Young Patient with Proteinuria

Abstract

Membranous nephropathy is a common form of glomerulonephritis that typically presents with nephrotic syndrome between the 3rd and 5th decades and one-third of patients experience spontaneous remission. Here, a patient with primary membranous nephropathy is presented.

Keywords

• Primary Membranous Glomerulonephritis
• glomerulonephritis
• proteinuria

References

1. Steinhäuslin F, Wauters JP. Quantitation of proteinuria in kidney transplant patients: accuracy of the urinary protein/creatinine ratio. Clin Nephrol. 1995 Feb;43(2):110-5.
2. Hoxha E, Harendza S, Pinnschmidt H, Panzer U, Stahl RA. PLA2R antibody levels and clinical outcome in patients with membranous nephropathy and non-nephrotic range proteinuria under treatment with inhibitors of the renin-angiotensin system. PLoS One. 2014 Oct 14;9(10):e110681. doi: 10.1371/journal.pone.0110681.
3. Ronco P, Debiec H. Pathophysiology of extramembranous glomerulopathies. Fifty years of progress, from laboratory to patient. Biol Aujourdhui. 2013;207(4):249-59 (in French). doi: 10.1051/jbio/2013025.
4. Hoxha E, Kneißler U, Stege G, Zahner G, Thiele I, Panzer U, Harendza S, Helmchen UM, Stahl RA. Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy. Kidney Int. 2012 Oct;82(7):797-804. doi: 10.1038/ki.2012.209.
5. Bomback AS, Gharavi AG. Can genetics risk-stratify patients with membranous nephropathy? J Am Soc Nephrol. 2013 Jul;24(8):1190-2. doi: 10.1681/ASN.2013060576.
6. Debiec H, Hanoy M, Francois A, Guerrot D, Ferlicot S, Johanet C, Aucouturier P, Godin M, Ronco P. Recurrent membranous nephropathy in an allograft caused by IgG3κ targeting the PLA2 receptor. J Am Soc Nephrol. 2012 Dec;23(12):1949-54. doi: 10.1681/ASN.2012060577.
7. Larsen CP, Messias NC, Silva FG, Messias E, Walker PD. Determination of primary versus secondary membranous glomerulopathy utilizing phospholipase A2 receptor staining in renal biopsies. Mod Pathol. 2013 May;26(5):709-15. doi: 10.1038/modpathol.2012.207.
8. Beck LH Jr, Bonegio RG, Lambeau G, Beck DM, Powell DW, Cummins TD, Klein JB, Salant DJ. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med. 2009 Jul 2;361(1):11-21. doi: 10.1056/NEJMoa0810457.