Coexistence of Medullary and Papillary Thyroid Carcinomas Detected Incidentally

Abstract

Papillary thyroid carcinoma (PTC) and Medullary thyroid carcinoma (MTC) are extremely rare and constitute less than 0.5% of all thyroid malignancies. In this study, the prevelance and characteristics of 8 patients with simultaneous PTC and MTC diagnoses were evaluated.

Keywords

• Germline RET mutation
• Papillary thyroid carcinoma
• Medullary thyroid carcinoma
• Thyroid cancer

References

1. 1. SEER*Explorer: An interactive website for SEER cancer statistics [Internet]. Surveillance Research Program, National Cancer Institute. Available at: https://seer.cancer.gov/explorer/. Accessed September 14, 2020.
2. 2. Lloyd RV, Buehler D, Khanafshar E. Papillary thyroid carcinoma variants. Head Neck Pathol. 2011 Mar;5(1):51-6. doi: 10.1007/s12105-010-0236-9.
3. 3. Wells SA Jr, Asa SL, Dralle H, Elisei R, Evans DB, Gagel RF, Lee N, Machens A, Moley JF, Pacini F, Raue F, Frank-Raue K, Robinson B, Rosenthal MS, Santoro M, Schlumberger M, Shah M, Waguespack SG; American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma. Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma. Thyroid. 2015 Jun;25(6):567-610. doi: 10.1089/thy.2014.0335.
4. 4. Bayrak E, Serter R. Coexistence of papillary and medullary thyroid carcinoma: A rare entity. The Turkish Journal of Endocrinology and Metabolism. 2020;24:168-72. doi: 10.25179/tjem.2019-72499.
5. 5. Biscolla RP, Ugolini C, Sculli M, Bottici V, Castagna MG, Romei C, Cosci B, Molinaro E, Faviana P, Basolo F, Miccoli P, Pacini F, Pinchera A, Elisei R. Medullary and papillary tumors are frequently associated in the same thyroid gland without evidence of reciprocal influence in their biologic behavior. Thyroid. 2004 Nov;14(11):946-52. doi: 10.1089/thy.2004.14.946.
6. 6. Kim WG, Gong G, Kim EY, Kim TY, Hong SJ, Kim WB, Shong YK. Concurrent occurrence of medullary thyroid carcinoma and papillary thyroid carcinoma in the same thyroid should be considered as coincidental. Clin Endocrinol (Oxf). 2010 Feb;72(2):256-63. doi: 10.1111/j.1365-2265.2009.03622.x.
7. 7. Machens A, Dralle H. Simultaneous medullary and papillary thyroid cancer: a novel entity?. Ann Surg Oncol. 2012 Jan;19(1):37-44. doi: 10.1245/s10434-011-1795-z.
8. 8. Lim H, Devesa SS, Sosa JA, Check D, Kitahara CM. Trends in thyroid cancer incidence and mortality in the United States, 1974-2013. JAMA. 2017 Apr 4;317(13):1338-1348. doi: 10.1001/jama.2017.2719.

9. 9. Appetecchia M, Lauretta R, Barnabei A, Pieruzzi L, Terrenato I, Cavedon E, Mian C, Castagna MG, Elisei R; SIE (Italian Society of Endocrinology) Working Group. Epidemiology of simultaneous medullary and papillary thyroid carcinomas (MTC/PTC): An Italian multicenter study. Cancers (Basel). 2019 Oct 9;11(10):1516. doi: 10.3390/cancers11101516.