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Yıl 2021, Cilt: 3 Sayı: Supplement 1, 42 - 43, 07.03.2021
https://doi.org/10.46310/tjim.877068

Öz

Kaynakça

  • 1. Almeida AM, Ramos F. Acute myeloid leukemia in the older adults. Leuk Res Rep. 2016 Jun 16;6:1-7. doi: 10.1016/j.lrr.2016.06.001.
  • 2. Song X, Peng Y, Wang X, Chen Y, Jin L, Yang T, Qian M, Ni W, Tong X, Lan J. Incidence, Survival, and Risk Factors for Adults with Acute Myeloid Leukemia Not Otherwise Specified and Acute Myeloid Leukemia with Recurrent Genetic Abnormalities: Analysis of the Surveillance, Epidemiology, and End Results (SEER) Database, 2001-2013. Acta Haematol. 2018;139(2):115-127. doi: 10.1159/000486228.
  • 3. Döhner H, Weisdorf DJ, Bloomfield CD. Acute Myeloid Leukemia. N Engl J Med. 2015 Sep 17;373(12):1136-52. doi: 10.1056/NEJMra1406184.
  • 4. DiNardo CD, Jonas BA, Pullarkat V, Thirman MJ, Garcia JS, Wei AH, Konopleva M, Döhner H, Letai A, Fenaux P, Koller E, Havelange V, Leber B, Esteve J, Wang J, Pejsa V, Hájek R, Porkka K, Illés Á, Lavie D, Lemoli RM, Yamamoto K, Yoon SS, Jang JH, Yeh SP, Turgut M, Hong WJ, Zhou Y, Potluri J, Pratz KW. Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia. N Engl J Med. 2020 Aug 13;383(7):617-629. doi: 10.1056/NEJMoa2012971.
  • 5. DiNardo CD, Pratz K, Pullarkat V, Jonas BA, Arellano M, Becker PS, Frankfurt O, Konopleva M, Wei AH, Kantarjian HM, Xu T, Hong WJ, Chyla B, Potluri J, Pollyea DA, Letai A. Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia. Blood. 2019 Jan 3;133(1):7-17. doi: 10.1182/blood-2018-08-868752.

Venetoclax and Azacitidine in Relapsed/Refractory Acute Myeloid Leukemia and High Risk Myelodysplastic Syndrome: Bursa Uludag University Experience

Yıl 2021, Cilt: 3 Sayı: Supplement 1, 42 - 43, 07.03.2021
https://doi.org/10.46310/tjim.877068

Öz

The management of acute myeloid leukemia (AML) gradually turns into an individualized approach with the application of targeted therapies. Venetoclax is a BCL-2 inhibitor that is synergistic with azacitidine. In this case series, 14 patients diagnosed with relapsed / refractory AML and 1 MDS RAEB-1 were followed up with venetoclax + azacitidine in the Hematology Department Bursa Uludag University Faculty of Medicine were evaluated. The best responses obtained with venetoclax + azacitidine were complete remission (CR) in one patient, complete remission with incomplete hematologic recovery (CRi) in one patient, morphological leukemia-free state (MLFS) in 4 patients, and partial response (PR) in one patient. The median time to first response with treatment was one month (0.5-5). The time to enter early remission is critical. For this reason, deaths due to infection should be prevented. Although the toxicities of this combination therapy can be managed, close follow-up of the patients is mandatory. In conclusion, this combination therapy is promising as it is relatively well-tolerated, improves the quality of life, and prolongs survival.

Kaynakça

  • 1. Almeida AM, Ramos F. Acute myeloid leukemia in the older adults. Leuk Res Rep. 2016 Jun 16;6:1-7. doi: 10.1016/j.lrr.2016.06.001.
  • 2. Song X, Peng Y, Wang X, Chen Y, Jin L, Yang T, Qian M, Ni W, Tong X, Lan J. Incidence, Survival, and Risk Factors for Adults with Acute Myeloid Leukemia Not Otherwise Specified and Acute Myeloid Leukemia with Recurrent Genetic Abnormalities: Analysis of the Surveillance, Epidemiology, and End Results (SEER) Database, 2001-2013. Acta Haematol. 2018;139(2):115-127. doi: 10.1159/000486228.
  • 3. Döhner H, Weisdorf DJ, Bloomfield CD. Acute Myeloid Leukemia. N Engl J Med. 2015 Sep 17;373(12):1136-52. doi: 10.1056/NEJMra1406184.
  • 4. DiNardo CD, Jonas BA, Pullarkat V, Thirman MJ, Garcia JS, Wei AH, Konopleva M, Döhner H, Letai A, Fenaux P, Koller E, Havelange V, Leber B, Esteve J, Wang J, Pejsa V, Hájek R, Porkka K, Illés Á, Lavie D, Lemoli RM, Yamamoto K, Yoon SS, Jang JH, Yeh SP, Turgut M, Hong WJ, Zhou Y, Potluri J, Pratz KW. Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia. N Engl J Med. 2020 Aug 13;383(7):617-629. doi: 10.1056/NEJMoa2012971.
  • 5. DiNardo CD, Pratz K, Pullarkat V, Jonas BA, Arellano M, Becker PS, Frankfurt O, Konopleva M, Wei AH, Kantarjian HM, Xu T, Hong WJ, Chyla B, Potluri J, Pollyea DA, Letai A. Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia. Blood. 2019 Jan 3;133(1):7-17. doi: 10.1182/blood-2018-08-868752.

Ayrıntılar

Birincil Dil İngilizce
Konular İç Hastalıkları
Bölüm Short Report
Yazarlar

İbrahim Ethem PINAR
ULUDAG UNIVERSITY
0000-0001-9907-1498
Türkiye


Fahir ÖZKALEMKAŞ
ULUDAG UNIVERSITY
0000-0001-9710-134X
Türkiye


Vildan OZKOCAMAN
ULUDAG UNIVERSITY
0000-0003-0014-7398
Türkiye


Tuba ERSAL Bu kişi benim
ULUDAG UNIVERSITY
0000-0001-5419-3221
Türkiye


Cumali YALÇIN Bu kişi benim
ULUDAG UNIVERSITY
0000-0002-5129-2977
Türkiye


Bedrettin ORHAN
ULUDAG UNIVERSITY
0000-0003-3970-2344
Türkiye


Ömer CANDAR
ULUDAG UNIVERSITY
0000-0001-7602-6926
Türkiye

Yayımlanma Tarihi 7 Mart 2021
Gönderilme Tarihi 10 Şubat 2021
Kabul Tarihi 5 Mart 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 3 Sayı: Supplement 1

Kaynak Göster

EndNote
PINAR İE, ÖZKALEMKAŞ F, OZKOCAMAN V, ERSAL T, YALÇIN C, ORHAN B, CANDAR Ö (01 Mart 2021) Venetoclax and Azacitidine in Relapsed/Refractory Acute Myeloid Leukemia and High Risk Myelodysplastic Syndrome: Bursa Uludag University Experience. Turkish Journal of Internal Medicine 3 Supplement 1 42–43.

e-ISSN: 2687-4245 

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