Renal vein thrombosis (RVT) is the presence of thrombi in major renal veins or their branches and is a rare clinical entity. RVT is one of the common thrombotic complications of nephrotic syndrome or renal cell carcinoma. Hormonal contraception can also rarely cause this complication. Herein, we presented a case of renal vein thrombosis accompanied by subnephrotic proteinuria after oral contraception.
Mazhar HR, Aeddula NR. Renal vein thrombosis. 2021 Jun 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Avaliable at: https://www.ncbi.nlm.nih. gov/books/NBK536971/. Accessed January 31, 2022.
Sasaki Y, Shimabukuro A, Isegawa T, Tamori Y, Koshiishi T, Yonaha H. Renal vein thrombosis associated with oral contraception and smoking: a case report from Japan, with literature review. CEN Case Rep. 2014 May;3(1):100-5. doi: 10.1007/s13730-013-0095-9.
Ajmera A, Joshi A, Kamat B, Germaine P, Weisberg L. Idiopathic acute renal vein thrombosis in a young healthy woman with no hypercoagulable state taking oral contraceptives. Am J Med Sci. 2010 Apr;339(4):380-2. doi: 10.1097/MAJ.0b013e3181ce4f34.
Böhler J, Hauenstein KH, Hasler K, Schollmeyer P. Renal vein thrombosis in a dehydrated patient on an oral contraceptive agent. Nephrol Dial Transplant. 1989;4(11):993-5. doi: 10.1093/ ndt/4.11.993.
Lidegaard Ø, Løkkegaard E, Svendsen AL, Agger C. Hormonal contraception and risk of venous thromboembolism: national follow-up study. BMJ. 2009 Aug 13;339:b2890. doi: 10.1136/bmj. b2890.
Chan HH, Douketis JD, Nowaczyk MJ. Acute renal vein thrombosis, oral contraceptive use, and hyperhomocysteinemia. Mayo Clin Proc. 2001 Feb;76(2):212-4. doi: 10.4065/76.2.212.
Girolami A, Simioni P, Girolami B, Zanardi S. The role of drugs, particularly oral contraceptives, in triggering thrombosis in congenital defects of coagulation inhibitors: a study of six patients. Blood Coagul Fibrinolysis. 1991 Oct;2(5):673-8. doi: 10.1097/00001721-199110000-00015.
Kim HK, Choi HH, Lee JM, Huh S. Acute renal vein thrombosis, oral contraceptives, and protein S deficiency: a successful catheter-directed thrombolysis. Ann Vasc Surg. 2009 Sep- Oct;23(5):687.e1-4. doi: 10.1016/j.avsg.2009.01.006.
Patole S, Ramya I. Bilateral renal vein thrombosis due to elevated factor VIII levels. J Assoc Physicians India. 2015 Aug;63(8):87-8. 10.
Goldman RS, Kettwich DL, Woodside JR, Borden TA. Mild unilateral proteinuria and renal vein thrombosis associated with oral contraceptive usage. Am J Kidney Dis. 1983 Jan;2(4):471-3. doi: 10.1016/s0272-6386(83)80080-8.
Barré P, Bishinsky J, Roy D, Roy A, Cooper B. Successful treatment with streptokinase of renal vein thrombosis associated with oral contraceptive use. Am J Nephrol. 1986;6(4):316-20. doi: 10.1159/000167182.
Mazhar HR, Aeddula NR. Renal vein thrombosis. 2021 Jun 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Avaliable at: https://www.ncbi.nlm.nih. gov/books/NBK536971/. Accessed January 31, 2022.
Sasaki Y, Shimabukuro A, Isegawa T, Tamori Y, Koshiishi T, Yonaha H. Renal vein thrombosis associated with oral contraception and smoking: a case report from Japan, with literature review. CEN Case Rep. 2014 May;3(1):100-5. doi: 10.1007/s13730-013-0095-9.
Ajmera A, Joshi A, Kamat B, Germaine P, Weisberg L. Idiopathic acute renal vein thrombosis in a young healthy woman with no hypercoagulable state taking oral contraceptives. Am J Med Sci. 2010 Apr;339(4):380-2. doi: 10.1097/MAJ.0b013e3181ce4f34.
Böhler J, Hauenstein KH, Hasler K, Schollmeyer P. Renal vein thrombosis in a dehydrated patient on an oral contraceptive agent. Nephrol Dial Transplant. 1989;4(11):993-5. doi: 10.1093/ ndt/4.11.993.
Lidegaard Ø, Løkkegaard E, Svendsen AL, Agger C. Hormonal contraception and risk of venous thromboembolism: national follow-up study. BMJ. 2009 Aug 13;339:b2890. doi: 10.1136/bmj. b2890.
Chan HH, Douketis JD, Nowaczyk MJ. Acute renal vein thrombosis, oral contraceptive use, and hyperhomocysteinemia. Mayo Clin Proc. 2001 Feb;76(2):212-4. doi: 10.4065/76.2.212.
Girolami A, Simioni P, Girolami B, Zanardi S. The role of drugs, particularly oral contraceptives, in triggering thrombosis in congenital defects of coagulation inhibitors: a study of six patients. Blood Coagul Fibrinolysis. 1991 Oct;2(5):673-8. doi: 10.1097/00001721-199110000-00015.
Kim HK, Choi HH, Lee JM, Huh S. Acute renal vein thrombosis, oral contraceptives, and protein S deficiency: a successful catheter-directed thrombolysis. Ann Vasc Surg. 2009 Sep- Oct;23(5):687.e1-4. doi: 10.1016/j.avsg.2009.01.006.
Patole S, Ramya I. Bilateral renal vein thrombosis due to elevated factor VIII levels. J Assoc Physicians India. 2015 Aug;63(8):87-8. 10.
Goldman RS, Kettwich DL, Woodside JR, Borden TA. Mild unilateral proteinuria and renal vein thrombosis associated with oral contraceptive usage. Am J Kidney Dis. 1983 Jan;2(4):471-3. doi: 10.1016/s0272-6386(83)80080-8.
Barré P, Bishinsky J, Roy D, Roy A, Cooper B. Successful treatment with streptokinase of renal vein thrombosis associated with oral contraceptive use. Am J Nephrol. 1986;6(4):316-20. doi: 10.1159/000167182.
Mehmet Sezen
ULUDAG UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, NEPHROLOGY (MEDICINE)0000-0001-5796-6445Türkiye
Abdülmecit Yıldız
ULUDAG UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, NEPHROLOGY (MEDICINE)0000-0001-5941-9103Türkiye
Ayşegül Oruç
ULUDAG UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, NEPHROLOGY (MEDICINE)0000-0002-0342-9692Türkiye
Kamil Dilek
ULUDAG UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, NEPHROLOGY (MEDICINE)0000-0001-6149-1913Türkiye
Mustafa Güllülü
ULUDAG UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, NEPHROLOGY (MEDICINE)0000-0002-8911-7189Türkiye
Mahmut Yavuz
ULUDAG UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, NEPHROLOGY (MEDICINE)0000-0001-6755-6386Türkiye
Saide Güllülü
ULUDAG UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, NEPHROLOGY (MEDICINE)0000-0001-6048-1879Türkiye
Alparslan Ersoy
ULUDAG UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, NEPHROLOGY (MEDICINE)0000-0002-0710-0923Türkiye
Görünen A, Sezen M, Yıldız A, Oruç A, Dilek K, Güllülü M, Yavuz M, Güllülü S, Ersoy A (April 1, 2022) A Case of Proteinuria Developing Secondary to Solitary Renal Vein Thrombosis Due to Oral Contraceptive Use. Turkish Journal of Internal Medicine 4 102–104.
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