AN EVALUATION OF QUALITY OF LIFE AND MUSCLE STRENGTH IN ADULT CANCER PATIENTS RECEIVING TREATMENT

Abstract

Purpose: Studies investigating muscle strength in cancer patients treating in the outpatient setting are limited. The aim of this study was to investigate the quality of life and muscle strength of adult cancer patients in the treatment stage after cancer diagnosis. Methods: A total of 54 patients (32 F, 22 M, age=49.74±12.00 years) with solid tumors, 17 (31.5%) patients receiving chemotherapy (CT Group), 20 (37.0%) treated with CT and surgery (CT+S Group), and 17 (31.5%) undergoing chemotherapy, surgery and radiotherapy (CT+S+RT) were included. Patient characteristics were recorded. Quadriceps femoris muscle strength and handgrip strength were measured. The European Cancer Research and Treatment Organization Quality of Life Questionnaire (EORTC-QLQC30- European) was used to assess quality of life. Results: According to the quality of life scores, cognitive function was affected in the CT+S+RT Group compared to CT+S Group (p<0.05). Patients receiving CT, compared to patients receiving CT+S+RT Group in terms of shortness of breath and insomnia, quality of life was negatively affected, and patients receiving CT+S+RT Group were better in terms of general well-being (p<0.05). Female patients were significantly affected in terms of physical function, role function, pain and symptoms compared to male patients (p<0.05). Handgrip strength was correlated with quality of life functional score (r=0.416, p=0.003), phsical function (r=0,232, p=0.047), and occupational function (r=0,422, p=0.011). Score, physical function, and function. There was a relationship between quadriceps femoris muscle strength and functional socre (r=0,232, p=0,047), occupational function (r=0.243, p=0.040), and cognitive function (r=0.259, p=0.030) Conclusion: Quality of life of the patients receiving cancer treatment had a negative effect and this negative effect was higher in female patients than in men. It was observed that the patients with high upper extremity muscle strength had better physical function, function and function in terms of quality of life.

Keywords

• adult
• cancer
• cancer treatment

TEDAVİ GÖREN ERİŞKİN KANSER HASTALARINDA YAŞAM KALİTESİ VE KAS KUVVETİNİN DEĞERLENDİRİLMESİ

Öz

Amaç: Ayaktan tedavi gören kanser hastalarında kas kuvvetini değerlendiren çalışmalar sınırlıdır. Bu çalışmanın amacı, kanser tanısı almış ve kanser tedavisi gören erişkin hastalarında kas kuvveti ile yaşam kalitesi arasındaki ilişkiyi incelemekti. Yöntem: Çalışmaya solid tümör tanısı ile ayaktan kemoterapi alan 17 (% 31,5) olgu (KT grup), kemoterapi ve cerrahi tedavi alan 20 (% 37,0) olgu (KT+C grup) ve kemoterapi, cerrahi tedavi ve radyoterapi alan 17 (% 31,5) olgu (KT+C+RT grup) olmak üzere, toplam 54 hasta (32 K, 22 E, yaş=49,74±12,00 yıl) dahil edildi. Bireylerin demografik bilgileri kaydedildi. Alt ekstremitede quadriceps femoris kas kuvveti ve üst ekstremitede el kavrama kuvveti değerlendirildi. Yaşam kalitesini değerlendirmek için Avrupa Kanser Araştırma ve Tedavi Organizasyonu Yaşam Kalitesi Anketi (EORTC-QLQ-C30-European) kullanıldı. Sonuçlar: Yaşam kalitesi skorlarına göre, KT+C+RT grubun, KT+C gruba göre kognitif fonksiyon alt boyutunun etkilendiği belirlendi (p<0,05). KT grup hastaların, KT+C+RT grup hastalara göre; nefes darlığı ve uykusuzluk alt boyutu açısından yaşam kalitesinin olumsuz yönde etkilendiği saptandı (p<0,05). KT+C+RT grup hastaların, genel iyilik hali alt boyutu açısından diğer gruplardan daha iyi oldukları bulundu (p<0,05). Kadın hastaların fiziksel fonksiyon, rol fonksiyonu, ağrı ve semptom alt boyutları bakımından erkek hastalara göre anlamlı olarak daha fazla etkilendiği saptandı (p<0,05). El kavrama kuvveti ile yaşam kalitesi fonksiyonel skor (r=0,416, p=0,003), fiziksel fonksiyon (r=0,232, p=0,047) ve rol fonksiyonu (r=0,422, p=0,011) arasında istatistiksel olarak anlamlı ilişki olduğu belirlendi. Quadriceps kas kuvveti ile fiziksel fonksiyon (r=0,232 p=0,047), rol fonksiyonu (r=0,243, p=0,040) ve kognitif fonksiyon (r=0,259 p=0,030) arasında anlamlı ilişki olduğu bulundu. Tartışma: Tedavi alan kanser hastalarında üst ve alt ekstremite kas kuvveti ile yaşam kalitesinin fiziksel, kognitif ve rol fonksiyonlarını içeren fonksiyonel skoru ile ilişkilidir. Kanser tedavisi gören tüm hastaların yaşam kalitesinin olumsuz yönde etkilenebileceği ve bu olumsuz etkilenimlerin kadın hastalarda erkeklere göre daha fazla olabileceği saptandı.

Anahtar Kelimeler

• Kanser
• Tedavi
• Yetişkin
• Yaşam Kalitesi

Kaynakça

1. 1. Sherr CJ. Cancer cell cycles. Science (New York, NY). 1996;274(5293):1672-7.
2. 2. Collins I, Garrett MD. Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors. Current opinion in pharmacology. 2005;5(4):366-73.
3. 3. Dhital A, Pey T, Stanford MR. Visual loss and falls: a review. Eye (London, England). 2010;24(9):1437-46.
4. 4. Talbot LA, Musiol RJ, Witham EK, Metter EJ. Falls in young, middle-aged and older community dwelling adults: perceived cause, environmental factors and injury. BMC public health. 2005;5:86.
5. 5. Boyd R, Stevens JA. Falls and fear of falling: burden, beliefs and behaviours. Age and ageing. 2009;38(4):423-8.
6. 6. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012.
7. CA: a cancer journal for clinicians. 2015;65(2):87-108.
8. 7. Shen Q, Lu D, Schelin ME, Joud A, Cao Y, Adami HO, et al. Injuries before and after diagnosis of cancer: nationwide register based study. BMJ (Clinical research ed). 2016;354:i4218.

9. 8. Lipton A. Pathophysiology of bone metastases: how this knowledge may lead to therapeutic intervention. The journal of supportive oncology. 2004;2(3):205-13; discussion 13-4, 16-7, 19-20.
10. 9. Aaronson NK. Quantitative issues in health-related quality of life assessment. Health policy (Amsterdam, Netherlands). 1988;10(3):217-30.
11. 10. Gramatyka M. [Cardiotoxicity as undesired side effect in the treatment of breast cancer]. Postepy higieny i medycyny doswiadczalnej (Online). 2014;68:483-97.
12. 11. Chaveli-Lopez B. Oral toxicity produced by chemotherapy: A systematic review. Journal of clinical and experimental dentistry. 2014;6(1):e81-90.
13. 12. Chaveli-López B, Bagán-Sebastián JV. Treatment of oral mucositis due to chemotherapy. Journal of clinical and experimental dentistry. 2016;8(2):e201-9.
14. 13. Schmidt RT, Toews JV. Grip strength as measured by the Jamar dynamometer. Archives of physical medicine and rehabilitation. 1970;51(6):321-7.
15. 14. Cuthbert SC, Goodheart GJ. On the reliability and validity of manual muscle testing: a literature review. Chiropractic & Osteopathy. 2007;15:4.
16. 15. Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. Journal of the National Cancer Institute. 1993;85(5):365-76.
17. 16. Cankurtaran ES, Ozalp E, Soygur H, Ozer S, Akbiyik DI, Bottomley A. Understanding the reliability and validity of the EORTC QLQ-C30 in Turkish cancer patients. European journal of cancer care. 2008;17(1):98-104.
18. 17. Hinz A, Singer S, Brahler E. European reference values for the quality of life questionnaire EORTC QLQ-C30: Results of a German investigation and a summarizing analysis of six European general population normative studies. Acta oncologica (Stockholm, Sweden). 2014;53(7):958-65.
19. 18. Geue K, Sender A, Schmidt R, Richter D, Hinz A, Schulte T, et al. Gender-specific quality of life after cancer in young adulthood: a comparison with the general population. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. 2014;23(4):1377-86.
20. 19. Chan YM, Ng TY, Ngan HY, Wong LC. Quality of life in women treated with neoadjuvant chemotherapy for advanced ovarian cancer: a prospective longitudinal study. Gynecologic oncology. 2003;88(1):9-16.
21. 20. Safieddine N, Xu W, Quadri SM, Knox JJ, Hornby J, Sulman J, et al. Health-related quality of life in esophageal cancer: effect of neoadjuvant chemoradiotherapy followed by surgical intervention. The Journal of thoracic and cardiovascular surgery. 2009;137(1):36-42.