Investigation of AOPP (Advanced Oxidation Protein Product), total sulfhydryl group (T-SH) and ceruloplasmin levels in sheep with parasitic liver disease

Year 2025, Volume: 9 Issue: 2, 101 - 107, 30.10.2025

Fatma Ertaş Oğuz , Adnan Ayan , Özlem Orunç Kılınç , Ahmet Ufuk Kömüroğlu , Nazmi Yüksek

https://doi.org/10.47748/tjvr.1592654

Abstract

Objectives: Helminths that attack the liver cause significant economic damage to the sheep industry due to low productivity and threat to flock health. In parasitic infections, the immune system and oxidative stress mechanisms are activated, which causes changes in some biochemical parameters. The aim of this study was to investigate the levels of AOPP, Total Sulfhydryl Group (T-SH) and ceruloplasmin in sheep with parasitic liver disease
Materials and Methods: in this study, 75 sheep blood serum (60 patients and 15 controls) were used. In the study, the ear tag numbers of the animals brought to the Iğdır Central Brothers Slaughterhouse for slaughter were noted, general checks were made, blood and feces samples were taken. Then, the slaughtering stages of the animals were followed and Fascioliasis, Echinococcosis, Dicroceliosis, Echinococcsis + Dicroceliosis, positive samples formed the study group. Blood taken from animals without any disease symptoms and organ lesions was used as control blood. Oxidative parameter AOPP, antioxidant parameter T-SH and acute phase protein ceruloplasmin and some biochemical levels were measured in all groups by using an atomic absorption spectrophotometer.
Results: AOPP levels in Fasciola spp. and Echinococcus spp. + D. dendriticum groups were significantly higher compared to control and D. dendriticum groups (p<0.05). The ceruloplasmin level in the control group was found to be significantly lower compared to Fasciola spp., Echinococcus spp. and D. dendriticum groups (p<0.05). Although total sulfhydryl level was lower in the patient groups compared to the healthy group, it was not significant.
Conclusions: These results suggest that cellular damage occurs in liver parasitism. These parameters are thought to be valuable in terms of prognosis in parasitic infections. In addition, oxidative cell damage is thought to occur in the attack of zoonotic liver parasites in which the immune response is reduced

Keywords

Antioxidant , Liver , Oxidative stress , Parasitic disease , Sheep

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