The effect of intra articular application of adipose tissue-derived mesenchymal stem cells on the clinical complaints in two cats with osteochondrodysplasia

Year 2025, Volume: 9 Issue: 2, 137 - 142, 30.10.2025

Yasin Parlatır , Yalçın Alper Özturan , İbrahim Süner , Burak Antakyalıoğlu , Mümin Alper Erdoğan

https://doi.org/10.47748/tjvr.1616194

https://izlik.org/JA94FU97GY

Abstract

Osteochondrodysplasia is a degenerative joint condition caused by a TRPV4 gene mutation, predominantly affecting Scottish Fold cats. This study evaluated the effects of adipose-derived mesenchymal stem cells (MSCs) in two Scottish Fold cats diagnosed with osteochondrodysplasia. Case 1 involved a 3-year-old cat with a one-month history of lameness and joint degeneration, while Case 2 featured a 4-year-old cat with a five-month history of similar symptoms. MSCs were isolated, characterized at passage 3, and administered intra-articularly at a dose of 1 × 10^6 cells/kg body weight. Both cats demonstrated significant clinical improvement, including resolution of lameness and increased mobility, despite persistent radiographic abnormalities. These findings suggest that MSC therapy may effectively alleviate clinical symptoms of osteochondrodysplasia. Further research is needed to explore its long-term efficacy and correlation with imaging outcomes.

Keywords

Osteochondrodisplazi , cat , stem cell , adipose , mesenchimal

Ethical Statement

ETHICAL STATEMENT The cat’s owners were provided with comprehensive verbal and written information regarding the proposed intervention, and the owner’s informed consent was duly obtained. Ethics committee approval for the current case report was submitted to the Kirikkale University Animal Experiments Ethics Committee, and it was confirmed that no ethics committee permission is required

Supporting Institution

This case report was supported by Adnan Menderes University techocity firm Chiron Pharma Mikrostem company in stem cell supply. The content is solely the authors' responsibility and does not necessarily represent the official views of the Mikrostem company

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