The effects of Juniperus communis (Cupressaceae) oil application on the serum paraoxonase and pancreatic enzymes activities and lipid levels in experimental diabetic rats

Abstract

Objective:Juniperus communis (JC) oil, which is among the medicinal plants, has many pharmacological activities. In this study, effects of JC oil on serum paraoxonase and pancreatic enzymes levels, lipid levels in experimental diabetic rats were investigated.

Materials and Methods:Thirty two male Wistar-Albino rats (250-300 g) were used as material. The rats were divided into four groups of control (C), diabetes (D), JC oil (J),  and diabetes + JC oil (DJ). D and DJ groups were treated with 45 mg/kg streptozotocin (STZ) (i.p.). JC oil (dissolved in distilled water (0.5% CMC)  was administered as 200 mg/kg/21 days by oral gavage in J and DJ groups.

Results:Total cholesterol (TC) and total  triglyceride (TG) levels were observed to have significantly decreased in the J and DJ groups to C and D groups (p≤0.001). There was no difference in TG levels between D group and control group. (p≥0.05). Lipoprotein levels were not statistically significant among all groups (p≥0.05). According to the control group in the diabetes and DJ groups; significantly decreased amylase levels and increased lipase levels (p≤0.001). Paraoxonase activity was have a significant decrease in D group  (p≤0.05). It was identified that the PON levels were significantly increase in the study groups when compared to the diabet group (p≤0.05).

Conclusion:The application of JC oil was effective in antihyperglycemia, antihyperlipidemic diabetes. In the other hand the antioxidant PON caused an increase. As a result, it can be effective in reducing the complications that may occur with lipids in diabetes.

Keywords

• Diabetes,Juniperus communis oil,Paraoxonase,Lipoproteins,Lipids

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