Araştırma Makalesi
BibTex RIS Kaynak Göster
Yıl 2021, Cilt: 5 Sayı: 1, 25 - 33, 22.03.2021
https://doi.org/10.47748/tjvr.861722

Öz

Destekleyen Kurum

Fırat Üniversitesi Araştırma Projeleri Birimi

Proje Numarası

VF 17.03

Teşekkür

Fırat Üniversitesi Araştırma Projeleri Birimine desteklerinden dolayı teşekkür ederiz.

Kaynakça

  • Agosa ET. Physical and Physiological Characteristics’ of Seed of Sesame (Sesamum indicum L.) Varieties Grown in Nigeria. University of Agriculture, Department of Plant Breeding And Seed Technology College of Plant Science And Crop Production, Master Thesis, Abeokuta, 2011.
  • Ali BH, Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother Res. 2003; 17:299-306 .
  • Anonymous 1. Seed. Available at: https://www.fairdinkumseeds.com/products-page/brassica-lettuce-and-asian greens/sesame-indicum-white-sesame-seeds/. Accessed May 20, 2017.
  • Arici M, Sagdic O, Gecgel U. Antibacterial effect of Turkish black cumin (Nigella sativa L.) oils. Grasas Y Aceites. 2005; 56:259-62.
  • Blumenthal M. St John’ s Wort. American Botanical Council. 1998; 11:470-85.
  • Bocci V. The case for oxygen-ozonetherapy. Br J Biomed Sci. 2007; 64:44-9.
  • Burits M, Bucar F. Antioxidant activity of Nigella sativa essential oil. Phytother Res. 2000; 14:323-8.
  • Cingi Mİ. Sarı kantaron yağının yara iyileştirmesindeki yeri. Anadolu Tıp Derg. 1991; 13:35-9.
  • Çırak C. Farklı doku kültürü uygulamalarının iki kantaron türünde (Hypericum perforatum ve H. bupleuroides) mikroçoğaltım yeteneği ve hiperisin ile toplam fenolik birikimi üzerine etkileri, Doktora Tezi, Ondokuz Mayıs Üniversitesi Fen Bilimleri Enstitüsü, Samsun, 2006.
  • Cotran RS, Kumar V, Collins T. Robbins Pathologic Basis of Disease. 2nd ed. Philadilphia: WB Saunders; 1999. p.107-9.
  • Di Carlo G, Borrelli F, Ernst E, Izzo AA. St John‘s wort: Prozac from the plant Kingdom. Trends Pharmacol Sci. 2001; 22(6):292-7.
  • Dunic GZ. Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in rats. Phytother Res. 2009; 23(11):1559-64.
  • Engin A. Yara iyileşmesi. In: Sayek İ ed. Temel Cerrahi El Kitabı. Ankara: Güneş Tıp Kitapevleri, 2009. p.135-40.
  • Gençcelep M, Aslan L, Yüksel H, Karasu A, Bakır B. Otolog fibrin yapıştırıcının açık yara tedavisinde iyileşme üzerine etkisi: deneysel çalışma. YYÜ Vet Fak Derg. 2001; 12(1- 2):101-4 .
  • Greeson JM, Sanford B, Monti DA. St. John's wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literature. Psychopharmacology. 2001; 153:402-14.
  • Hammer KDP, Hilwing ML, Solco AKS. Inhibition of prostoglandin E2 production by antiinflamatuar Hypericum perforatum extracts and constituents in RAW264.7 mouse macrophage cells. J Agric Food Chem. 2007;55:7323-31.
  • Hunt EJ, Lester CAE, Lester EA, Tackett RL. Effect of St. John's wort on free radikal production. Life Sciences. 2001; 69:181-90.
  • Islam SK, Ahsan M, Hassan CM, Malek MA. Antifungal activities of the oils of Nigella sativa seeds. Pak J Pharm Sci. 1989; 2:25-8.
  • Kang MH. Mode of action of sesame ligands in protecting low density lipoprotein against oxidative dame in vitro. Life Sci. 2000; 66:161-71.
  • Kim HS, Noh SU, Han YW, Kim KM, Kang H, Kim HO, et al. Therapeutic effects of topical application of ozone on acute cutaneous wound healing. J Korean Med Sci. 2009;24(3):368-74.
  • Lavagna SM, Secci D. Efficacy of Hypericum and Calendula oils in the epithelial reconstruction of surgical wounds in childbirth with caesarean section. Farmaco. 2001; 56: 451-3.
  • Lazarus GS, Cooper DM, Knighton DN, Margolis DJ, Percoraro Re, Rodeheaver G, et al. Definitions and Guidelines for Assessment of Wounds and Evaluation of Healing. Arch Dermatol. 1994; 130(4):489-93.
  • Li J, Chen J, Kirsner R. Pathophysiology of Acute Wound Healing. Clin Dermatol. 2007; 25:9-18.
  • Öztürk N, Korkmaz S, Öztürk Y. Wound-healing activity of St. John’s wort (Hypericum perforatum L.) on chicken embryonic fibroblasts, J Ethnopharmacol. 2007;111(1):33-9.
  • Robbins KC. Temel Patoloji (Basic Patology). 5th edition, İstanbul: Nobel Tıp Kitapevleri; 1992. p.47-60. Strodtbeck F. Physiology of wound healing. New Inf Nurs Rev. 2001; 1:43-52.
  • Suja KP. Antioksidant efficacy of sesame cake extract in vegetable oil protection. Food Chem. 1998; 84:393-400.
  • Valacchi G, Lim Y, Belmonte G, Miracco C, Zanardi I, Bocci V, et al. Ozonated sesame oil enhances cutaneous wound healing in SKH1 mice. Wound Repair Regen. 2011; 19:107-15.
  • Viebahn-Haensler R. The Use of Ozone in Medicine. Heidelberg: Karl F. Haug; 2002. p.83-4.
  • Witte MB, Barbul A. General principles of wound healing. Surg Clin of North Am. 1997; 77(3):509-28.

Effects on the Wound Healing Process Using Ozonated Oils (Sesame, Nigella sativa, Hypericum perforatum) in Rats

Yıl 2021, Cilt: 5 Sayı: 1, 25 - 33, 22.03.2021
https://doi.org/10.47748/tjvr.861722

Öz

Objective: In this study, the effects of three different ozonated oils (Sesame, Nigella sativa, and Hypericum perforatum) on wound closure rate, healing process, and possible complications were examined macroscopically and microscopically.
Materials and Methods: Twenty-one adult Wistar albino female rats were used in the study. Subjects were divided into three groups, early wound healing, (7 days), medium wound healing, (14 days), and late wound healing (21 days). Four full-thickness skin wounds of equal size (10 mm in diameter) were formed on the back regions of all rats. This region was chosen for preventing self-inflicted injuries and reducing external irritation. The wound was left open during the healing process. While the first wound (control) received no treatment in the second wound, ozonated Sesame oil, in the third wound ozonated Nigella sativa oil, and in the fourth wound ozonated Hypericum perforatum oil were used. No group obtained parenteral drug administration. The first, second, and third main groups were euthanized on days 7, 14, and 21, respectively. The wound healing was assessed macroscopically daily. Wound sizes of individual rats were measured with a caliper and digitally photographed every day from the day of injury. After euthanasia, all wound sites of the subjects were evaluated histopathologically.
Results: There were no significant differences in wound healing between treatments on the first day 7. On the 14, it was found that the healing was better in the group that applied Nigella sativa and Sesame oils (p≤0.05). On day 21 wound healing was completed in all subjects with a resultant of better outcome in Nigella sativa oil treatment compared with others (p≤0.01).
Conclusion: In this study, the best wound healing outcome was achieved with Nigella sativa oil and Sesame oil where three different minced oils were used.

Proje Numarası

VF 17.03

Kaynakça

  • Agosa ET. Physical and Physiological Characteristics’ of Seed of Sesame (Sesamum indicum L.) Varieties Grown in Nigeria. University of Agriculture, Department of Plant Breeding And Seed Technology College of Plant Science And Crop Production, Master Thesis, Abeokuta, 2011.
  • Ali BH, Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother Res. 2003; 17:299-306 .
  • Anonymous 1. Seed. Available at: https://www.fairdinkumseeds.com/products-page/brassica-lettuce-and-asian greens/sesame-indicum-white-sesame-seeds/. Accessed May 20, 2017.
  • Arici M, Sagdic O, Gecgel U. Antibacterial effect of Turkish black cumin (Nigella sativa L.) oils. Grasas Y Aceites. 2005; 56:259-62.
  • Blumenthal M. St John’ s Wort. American Botanical Council. 1998; 11:470-85.
  • Bocci V. The case for oxygen-ozonetherapy. Br J Biomed Sci. 2007; 64:44-9.
  • Burits M, Bucar F. Antioxidant activity of Nigella sativa essential oil. Phytother Res. 2000; 14:323-8.
  • Cingi Mİ. Sarı kantaron yağının yara iyileştirmesindeki yeri. Anadolu Tıp Derg. 1991; 13:35-9.
  • Çırak C. Farklı doku kültürü uygulamalarının iki kantaron türünde (Hypericum perforatum ve H. bupleuroides) mikroçoğaltım yeteneği ve hiperisin ile toplam fenolik birikimi üzerine etkileri, Doktora Tezi, Ondokuz Mayıs Üniversitesi Fen Bilimleri Enstitüsü, Samsun, 2006.
  • Cotran RS, Kumar V, Collins T. Robbins Pathologic Basis of Disease. 2nd ed. Philadilphia: WB Saunders; 1999. p.107-9.
  • Di Carlo G, Borrelli F, Ernst E, Izzo AA. St John‘s wort: Prozac from the plant Kingdom. Trends Pharmacol Sci. 2001; 22(6):292-7.
  • Dunic GZ. Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in rats. Phytother Res. 2009; 23(11):1559-64.
  • Engin A. Yara iyileşmesi. In: Sayek İ ed. Temel Cerrahi El Kitabı. Ankara: Güneş Tıp Kitapevleri, 2009. p.135-40.
  • Gençcelep M, Aslan L, Yüksel H, Karasu A, Bakır B. Otolog fibrin yapıştırıcının açık yara tedavisinde iyileşme üzerine etkisi: deneysel çalışma. YYÜ Vet Fak Derg. 2001; 12(1- 2):101-4 .
  • Greeson JM, Sanford B, Monti DA. St. John's wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literature. Psychopharmacology. 2001; 153:402-14.
  • Hammer KDP, Hilwing ML, Solco AKS. Inhibition of prostoglandin E2 production by antiinflamatuar Hypericum perforatum extracts and constituents in RAW264.7 mouse macrophage cells. J Agric Food Chem. 2007;55:7323-31.
  • Hunt EJ, Lester CAE, Lester EA, Tackett RL. Effect of St. John's wort on free radikal production. Life Sciences. 2001; 69:181-90.
  • Islam SK, Ahsan M, Hassan CM, Malek MA. Antifungal activities of the oils of Nigella sativa seeds. Pak J Pharm Sci. 1989; 2:25-8.
  • Kang MH. Mode of action of sesame ligands in protecting low density lipoprotein against oxidative dame in vitro. Life Sci. 2000; 66:161-71.
  • Kim HS, Noh SU, Han YW, Kim KM, Kang H, Kim HO, et al. Therapeutic effects of topical application of ozone on acute cutaneous wound healing. J Korean Med Sci. 2009;24(3):368-74.
  • Lavagna SM, Secci D. Efficacy of Hypericum and Calendula oils in the epithelial reconstruction of surgical wounds in childbirth with caesarean section. Farmaco. 2001; 56: 451-3.
  • Lazarus GS, Cooper DM, Knighton DN, Margolis DJ, Percoraro Re, Rodeheaver G, et al. Definitions and Guidelines for Assessment of Wounds and Evaluation of Healing. Arch Dermatol. 1994; 130(4):489-93.
  • Li J, Chen J, Kirsner R. Pathophysiology of Acute Wound Healing. Clin Dermatol. 2007; 25:9-18.
  • Öztürk N, Korkmaz S, Öztürk Y. Wound-healing activity of St. John’s wort (Hypericum perforatum L.) on chicken embryonic fibroblasts, J Ethnopharmacol. 2007;111(1):33-9.
  • Robbins KC. Temel Patoloji (Basic Patology). 5th edition, İstanbul: Nobel Tıp Kitapevleri; 1992. p.47-60. Strodtbeck F. Physiology of wound healing. New Inf Nurs Rev. 2001; 1:43-52.
  • Suja KP. Antioksidant efficacy of sesame cake extract in vegetable oil protection. Food Chem. 1998; 84:393-400.
  • Valacchi G, Lim Y, Belmonte G, Miracco C, Zanardi I, Bocci V, et al. Ozonated sesame oil enhances cutaneous wound healing in SKH1 mice. Wound Repair Regen. 2011; 19:107-15.
  • Viebahn-Haensler R. The Use of Ozone in Medicine. Heidelberg: Karl F. Haug; 2002. p.83-4.
  • Witte MB, Barbul A. General principles of wound healing. Surg Clin of North Am. 1997; 77(3):509-28.
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Cerrahi
Bölüm 2021 Volume 5 Number 1
Yazarlar

İbrahim Canpolat 0000-0001-7196-5529

Yesari Eröksüz 0000-0001-5962-8810

Tamara Rızaoğlu Bu kişi benim 0000-0002-1613-7162

Proje Numarası VF 17.03
Yayımlanma Tarihi 22 Mart 2021
Gönderilme Tarihi 15 Ocak 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 5 Sayı: 1

Kaynak Göster

APA Canpolat, İ., Eröksüz, Y., & Rızaoğlu, T. (2021). Effects on the Wound Healing Process Using Ozonated Oils (Sesame, Nigella sativa, Hypericum perforatum) in Rats. Turkish Journal of Veterinary Research, 5(1), 25-33. https://doi.org/10.47748/tjvr.861722
AMA Canpolat İ, Eröksüz Y, Rızaoğlu T. Effects on the Wound Healing Process Using Ozonated Oils (Sesame, Nigella sativa, Hypericum perforatum) in Rats. TJVR. Mart 2021;5(1):25-33. doi:10.47748/tjvr.861722
Chicago Canpolat, İbrahim, Yesari Eröksüz, ve Tamara Rızaoğlu. “Effects on the Wound Healing Process Using Ozonated Oils (Sesame, Nigella Sativa, Hypericum Perforatum) in Rats”. Turkish Journal of Veterinary Research 5, sy. 1 (Mart 2021): 25-33. https://doi.org/10.47748/tjvr.861722.
EndNote Canpolat İ, Eröksüz Y, Rızaoğlu T (01 Mart 2021) Effects on the Wound Healing Process Using Ozonated Oils (Sesame, Nigella sativa, Hypericum perforatum) in Rats. Turkish Journal of Veterinary Research 5 1 25–33.
IEEE İ. Canpolat, Y. Eröksüz, ve T. Rızaoğlu, “Effects on the Wound Healing Process Using Ozonated Oils (Sesame, Nigella sativa, Hypericum perforatum) in Rats”, TJVR, c. 5, sy. 1, ss. 25–33, 2021, doi: 10.47748/tjvr.861722.
ISNAD Canpolat, İbrahim vd. “Effects on the Wound Healing Process Using Ozonated Oils (Sesame, Nigella Sativa, Hypericum Perforatum) in Rats”. Turkish Journal of Veterinary Research 5/1 (Mart 2021), 25-33. https://doi.org/10.47748/tjvr.861722.
JAMA Canpolat İ, Eröksüz Y, Rızaoğlu T. Effects on the Wound Healing Process Using Ozonated Oils (Sesame, Nigella sativa, Hypericum perforatum) in Rats. TJVR. 2021;5:25–33.
MLA Canpolat, İbrahim vd. “Effects on the Wound Healing Process Using Ozonated Oils (Sesame, Nigella Sativa, Hypericum Perforatum) in Rats”. Turkish Journal of Veterinary Research, c. 5, sy. 1, 2021, ss. 25-33, doi:10.47748/tjvr.861722.
Vancouver Canpolat İ, Eröksüz Y, Rızaoğlu T. Effects on the Wound Healing Process Using Ozonated Oils (Sesame, Nigella sativa, Hypericum perforatum) in Rats. TJVR. 2021;5(1):25-33.