Case Report
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Year 2025, Volume: 9 Issue: 2, 143 - 149, 30.10.2025
https://doi.org/10.47748/tjvr.1715305

Abstract

References

  • Bacek LM, Macintire DK. Treatment of primary immune-mediated hemolytic anemia with mycophenolate mofetil in two cats. J Vet Emerg Crit Care. 2011;21(1):45-49.
  • Cusack B, Buggy DJ. Anaesthesia, analgesia, and the surgical stress response. BJA Education. 2020;20 (9): 321–328.
  • Ettinger SJ, Feldman EC. Textbook of Veterinary Internal Medicine. 8th ed. E-Book: Elsevier; 2017.
  • Fingland RB. The Uterus. In Current techniques in small animal surgery, 5th ed, Williams & Wilkins; 1998.
  • Garden OA, Kidd L, Mexas AM, et. al. ACVIM consensus statement on the diagnosis of immune-mediated hemolytic anemia in dogs and cats. J Vet Intern Med. 2019;33:313-334.
  • Gunn-Moore DA, Day MJ, Graham MEA, Cue SM, Harbour DA. Immune-mediated haemolytic anaemia in two sibling cats associated with multicentric lymphoblastic infiltration. J Feline Med Surg. 1999; 1:209-214.
  • Hill QA, Stamps R, Massey E, et al. The diagnosis and management of primary autoimmune haemolytic anaemia. Br J Haematol. 2017;176:395-411.
  • Husbands BD, Smith SA, Weiss DJ. Idiopathic immune-mediated hemolytic anemia (IMHA) in cats. In: Proceedings of the American College of Veterinary Internal Medicine; Dallas, USA; 2002.
  • Kohn B, Weingart C, Eckmann V, Ottenjann M, Leibold W. Primary immune-mediated hemolytic anemia in 19 cats: diagnosis, therapy and outcome (1998–2004). J Vet Intern Med. 2006; 20:159-166.
  • Kopke MA, Sarah P, Craig GR. Presumed immune-mediated haemolytic anaemia associated with pregnancy in a cat. J Feline Med Surg Open Rep. 2019; 5(1):1-5.
  • LeVine DN, Kidd L, Garden OA, et al. ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats. J Vet Intern Med. 2024; 38(4):1958-1981.
  • Limlenglert P, Rungsipipat A, Pusoonthornthum R. Application of flow cytometry for early diagnosis and monitoring in cats with immune-mediated hemolytic anemia. Thai J Vet Med. 2011; 41(2):185-191.
  • Johnston SA, Tobias KM. Veterinary Surgery: Small Animal, 2nd ed. Saunders; 2017.
  • McCullough S. Immune-mediated hemolytic anemia: understanding the nemesis. Vet Clin North Am Small Anim Pract. 2003; 33:1295-1315.
  • Paes G, Paepe D, Veldeman J, Campos M, Daminet S. Immune-mediated hemolytic anemia (IMHA) in cats-part 1: a review. Vlaams Diergeneeskd Tijdschr. 2010; 79:415-422.
  • Sentürk S, Temizel M. Treatment of immune-mediated hemolytic anemia and thrombocytopenia with vincristine in a dog. J Res Vet Med. 2001; 20:85-91.
  • Whitley N. Dealing with immune-mediated haematological diseases in dogs and cats: 2. Thrombocytopenia and Evan's syndrome. In Pract. 2020; 42(1):20-25.

Evans syndrome following cesarean section and ovariohysterectomy in two cats: a rare postoperative complication

Year 2025, Volume: 9 Issue: 2, 143 - 149, 30.10.2025
https://doi.org/10.47748/tjvr.1715305

Abstract

This case report describes the diagnosis and treatment of immune-mediated hemolytic anemia (IMHA) and thrombocytopenia in two cats that underwent ovariohysterectomy following cesarean section. Both cats were presented at different times with dystocia. Cesarean sections were performed based on clinical evaluations including maternal condition, fetal heart rate, and labor progression, and were followed immediately by ovariohysterectomy. On postoperative days 1 and 4, respectively, both cats developed rapidly progressing, scattered bruising on the abdomen, despite being clinically stable. Physical examination revealed ecchymoses across the abdomen and other regions. Laboratory results indicated mild anemia with reduced hemoglobin, hematocrit, erythrocyte, and platelet counts. IMHA and thrombocytopenia were diagnosed based on clinical signs and the presence of spherocytes on blood smears. Immunosuppressive therapy led to full resolution of hematologic abnormalities in both cases. To the authors’ knowledge, this is the first report of IMHA and thrombocytopenia developing in cats following cesarean section and ovariohysterectomy. Although the exact underlying cause remains unclear, it is possible that surgical stress may have played a role to the development of immune-mediated hematologic complications in these cases.

Ethical Statement

This study does not present any ethical concerns.

References

  • Bacek LM, Macintire DK. Treatment of primary immune-mediated hemolytic anemia with mycophenolate mofetil in two cats. J Vet Emerg Crit Care. 2011;21(1):45-49.
  • Cusack B, Buggy DJ. Anaesthesia, analgesia, and the surgical stress response. BJA Education. 2020;20 (9): 321–328.
  • Ettinger SJ, Feldman EC. Textbook of Veterinary Internal Medicine. 8th ed. E-Book: Elsevier; 2017.
  • Fingland RB. The Uterus. In Current techniques in small animal surgery, 5th ed, Williams & Wilkins; 1998.
  • Garden OA, Kidd L, Mexas AM, et. al. ACVIM consensus statement on the diagnosis of immune-mediated hemolytic anemia in dogs and cats. J Vet Intern Med. 2019;33:313-334.
  • Gunn-Moore DA, Day MJ, Graham MEA, Cue SM, Harbour DA. Immune-mediated haemolytic anaemia in two sibling cats associated with multicentric lymphoblastic infiltration. J Feline Med Surg. 1999; 1:209-214.
  • Hill QA, Stamps R, Massey E, et al. The diagnosis and management of primary autoimmune haemolytic anaemia. Br J Haematol. 2017;176:395-411.
  • Husbands BD, Smith SA, Weiss DJ. Idiopathic immune-mediated hemolytic anemia (IMHA) in cats. In: Proceedings of the American College of Veterinary Internal Medicine; Dallas, USA; 2002.
  • Kohn B, Weingart C, Eckmann V, Ottenjann M, Leibold W. Primary immune-mediated hemolytic anemia in 19 cats: diagnosis, therapy and outcome (1998–2004). J Vet Intern Med. 2006; 20:159-166.
  • Kopke MA, Sarah P, Craig GR. Presumed immune-mediated haemolytic anaemia associated with pregnancy in a cat. J Feline Med Surg Open Rep. 2019; 5(1):1-5.
  • LeVine DN, Kidd L, Garden OA, et al. ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats. J Vet Intern Med. 2024; 38(4):1958-1981.
  • Limlenglert P, Rungsipipat A, Pusoonthornthum R. Application of flow cytometry for early diagnosis and monitoring in cats with immune-mediated hemolytic anemia. Thai J Vet Med. 2011; 41(2):185-191.
  • Johnston SA, Tobias KM. Veterinary Surgery: Small Animal, 2nd ed. Saunders; 2017.
  • McCullough S. Immune-mediated hemolytic anemia: understanding the nemesis. Vet Clin North Am Small Anim Pract. 2003; 33:1295-1315.
  • Paes G, Paepe D, Veldeman J, Campos M, Daminet S. Immune-mediated hemolytic anemia (IMHA) in cats-part 1: a review. Vlaams Diergeneeskd Tijdschr. 2010; 79:415-422.
  • Sentürk S, Temizel M. Treatment of immune-mediated hemolytic anemia and thrombocytopenia with vincristine in a dog. J Res Vet Med. 2001; 20:85-91.
  • Whitley N. Dealing with immune-mediated haematological diseases in dogs and cats: 2. Thrombocytopenia and Evan's syndrome. In Pract. 2020; 42(1):20-25.
There are 17 citations in total.

Details

Primary Language English
Subjects Veterinary Obstetrics and Gynecology
Journal Section 2025 Volume 9 Number 2
Authors

Ebru Karakaya Bilen 0000-0003-4837-1858

Öznur Yilmaz Koç 0000-0003-0424-9471

Ali Ünver 0000-0002-9683-7387

Mahsum Başak 0000-0003-1257-8283

Gülşah Akgül 0000-0003-4804-6502

Early Pub Date October 26, 2025
Publication Date October 30, 2025
Submission Date June 5, 2025
Acceptance Date July 30, 2025
Published in Issue Year 2025 Volume: 9 Issue: 2

Cite

APA Karakaya Bilen, E., Yilmaz Koç, Ö., Ünver, A., … Başak, M. (2025). Evans syndrome following cesarean section and ovariohysterectomy in two cats: a rare postoperative complication. Turkish Journal of Veterinary Research, 9(2), 143-149. https://doi.org/10.47748/tjvr.1715305
AMA Karakaya Bilen E, Yilmaz Koç Ö, Ünver A, Başak M, Akgül G. Evans syndrome following cesarean section and ovariohysterectomy in two cats: a rare postoperative complication. TJVR. October 2025;9(2):143-149. doi:10.47748/tjvr.1715305
Chicago Karakaya Bilen, Ebru, Öznur Yilmaz Koç, Ali Ünver, Mahsum Başak, and Gülşah Akgül. “Evans Syndrome Following Cesarean Section and Ovariohysterectomy in Two Cats: a Rare Postoperative Complication”. Turkish Journal of Veterinary Research 9, no. 2 (October 2025): 143-49. https://doi.org/10.47748/tjvr.1715305.
EndNote Karakaya Bilen E, Yilmaz Koç Ö, Ünver A, Başak M, Akgül G (October 1, 2025) Evans syndrome following cesarean section and ovariohysterectomy in two cats: a rare postoperative complication. Turkish Journal of Veterinary Research 9 2 143–149.
IEEE E. Karakaya Bilen, Ö. Yilmaz Koç, A. Ünver, M. Başak, and G. Akgül, “Evans syndrome following cesarean section and ovariohysterectomy in two cats: a rare postoperative complication”, TJVR, vol. 9, no. 2, pp. 143–149, 2025, doi: 10.47748/tjvr.1715305.
ISNAD Karakaya Bilen, Ebru et al. “Evans Syndrome Following Cesarean Section and Ovariohysterectomy in Two Cats: a Rare Postoperative Complication”. Turkish Journal of Veterinary Research 9/2 (October2025), 143-149. https://doi.org/10.47748/tjvr.1715305.
JAMA Karakaya Bilen E, Yilmaz Koç Ö, Ünver A, Başak M, Akgül G. Evans syndrome following cesarean section and ovariohysterectomy in two cats: a rare postoperative complication. TJVR. 2025;9:143–149.
MLA Karakaya Bilen, Ebru et al. “Evans Syndrome Following Cesarean Section and Ovariohysterectomy in Two Cats: a Rare Postoperative Complication”. Turkish Journal of Veterinary Research, vol. 9, no. 2, 2025, pp. 143-9, doi:10.47748/tjvr.1715305.
Vancouver Karakaya Bilen E, Yilmaz Koç Ö, Ünver A, Başak M, Akgül G. Evans syndrome following cesarean section and ovariohysterectomy in two cats: a rare postoperative complication. TJVR. 2025;9(2):143-9.