Year 2025,
Volume: 9 Issue: 2, 143 - 149, 30.10.2025
Ebru Karakaya Bilen
,
Öznur Yilmaz Koç
,
Ali Ünver
,
Mahsum Başak
,
Gülşah Akgül
References
-
Bacek LM, Macintire DK. Treatment of primary immune-mediated hemolytic anemia with mycophenolate mofetil in two cats. J Vet Emerg Crit Care. 2011;21(1):45-49.
-
Cusack B, Buggy DJ. Anaesthesia, analgesia, and the surgical stress response. BJA Education. 2020;20 (9): 321–328.
-
Ettinger SJ, Feldman EC. Textbook of Veterinary Internal Medicine. 8th ed. E-Book: Elsevier; 2017.
-
Fingland RB. The Uterus. In Current techniques in small animal surgery, 5th ed, Williams & Wilkins; 1998.
-
Garden OA, Kidd L, Mexas AM, et. al. ACVIM consensus statement on the diagnosis of immune-mediated hemolytic anemia in dogs and cats. J Vet Intern Med. 2019;33:313-334.
-
Gunn-Moore DA, Day MJ, Graham MEA, Cue SM, Harbour DA. Immune-mediated haemolytic anaemia in two sibling cats associated with multicentric lymphoblastic infiltration. J Feline Med Surg. 1999; 1:209-214.
-
Hill QA, Stamps R, Massey E, et al. The diagnosis and management of primary autoimmune haemolytic anaemia. Br J Haematol. 2017;176:395-411.
-
Husbands BD, Smith SA, Weiss DJ. Idiopathic immune-mediated hemolytic anemia (IMHA) in cats. In: Proceedings of the American College of Veterinary Internal Medicine; Dallas, USA; 2002.
-
Kohn B, Weingart C, Eckmann V, Ottenjann M, Leibold W. Primary immune-mediated hemolytic anemia in 19 cats: diagnosis, therapy and outcome (1998–2004). J Vet Intern Med. 2006; 20:159-166.
-
Kopke MA, Sarah P, Craig GR. Presumed immune-mediated haemolytic anaemia associated with pregnancy in a cat. J Feline Med Surg Open Rep. 2019; 5(1):1-5.
-
LeVine DN, Kidd L, Garden OA, et al. ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats. J Vet Intern Med. 2024; 38(4):1958-1981.
-
Limlenglert P, Rungsipipat A, Pusoonthornthum R. Application of flow cytometry for early diagnosis and monitoring in cats with immune-mediated hemolytic anemia. Thai J Vet Med. 2011; 41(2):185-191.
-
Johnston SA, Tobias KM. Veterinary Surgery: Small Animal, 2nd ed. Saunders; 2017.
-
McCullough S. Immune-mediated hemolytic anemia: understanding the nemesis. Vet Clin North Am Small Anim Pract. 2003; 33:1295-1315.
-
Paes G, Paepe D, Veldeman J, Campos M, Daminet S. Immune-mediated hemolytic anemia (IMHA) in cats-part 1: a review. Vlaams Diergeneeskd Tijdschr. 2010; 79:415-422.
-
Sentürk S, Temizel M. Treatment of immune-mediated hemolytic anemia and thrombocytopenia with vincristine in a dog. J Res Vet Med. 2001; 20:85-91.
-
Whitley N. Dealing with immune-mediated haematological diseases in dogs and cats: 2. Thrombocytopenia and Evan's syndrome. In Pract. 2020; 42(1):20-25.
Evans syndrome following cesarean section and ovariohysterectomy in two cats: a rare postoperative complication
Year 2025,
Volume: 9 Issue: 2, 143 - 149, 30.10.2025
Ebru Karakaya Bilen
,
Öznur Yilmaz Koç
,
Ali Ünver
,
Mahsum Başak
,
Gülşah Akgül
Abstract
This case report describes the diagnosis and treatment of immune-mediated hemolytic anemia (IMHA) and thrombocytopenia in two cats that underwent ovariohysterectomy following cesarean section. Both cats were presented at different times with dystocia. Cesarean sections were performed based on clinical evaluations including maternal condition, fetal heart rate, and labor progression, and were followed immediately by ovariohysterectomy. On postoperative days 1 and 4, respectively, both cats developed rapidly progressing, scattered bruising on the abdomen, despite being clinically stable. Physical examination revealed ecchymoses across the abdomen and other regions. Laboratory results indicated mild anemia with reduced hemoglobin, hematocrit, erythrocyte, and platelet counts. IMHA and thrombocytopenia were diagnosed based on clinical signs and the presence of spherocytes on blood smears. Immunosuppressive therapy led to full resolution of hematologic abnormalities in both cases. To the authors’ knowledge, this is the first report of IMHA and thrombocytopenia developing in cats following cesarean section and ovariohysterectomy. Although the exact underlying cause remains unclear, it is possible that surgical stress may have played a role to the development of immune-mediated hematologic complications in these cases.
Ethical Statement
This study does not present any ethical concerns.
References
-
Bacek LM, Macintire DK. Treatment of primary immune-mediated hemolytic anemia with mycophenolate mofetil in two cats. J Vet Emerg Crit Care. 2011;21(1):45-49.
-
Cusack B, Buggy DJ. Anaesthesia, analgesia, and the surgical stress response. BJA Education. 2020;20 (9): 321–328.
-
Ettinger SJ, Feldman EC. Textbook of Veterinary Internal Medicine. 8th ed. E-Book: Elsevier; 2017.
-
Fingland RB. The Uterus. In Current techniques in small animal surgery, 5th ed, Williams & Wilkins; 1998.
-
Garden OA, Kidd L, Mexas AM, et. al. ACVIM consensus statement on the diagnosis of immune-mediated hemolytic anemia in dogs and cats. J Vet Intern Med. 2019;33:313-334.
-
Gunn-Moore DA, Day MJ, Graham MEA, Cue SM, Harbour DA. Immune-mediated haemolytic anaemia in two sibling cats associated with multicentric lymphoblastic infiltration. J Feline Med Surg. 1999; 1:209-214.
-
Hill QA, Stamps R, Massey E, et al. The diagnosis and management of primary autoimmune haemolytic anaemia. Br J Haematol. 2017;176:395-411.
-
Husbands BD, Smith SA, Weiss DJ. Idiopathic immune-mediated hemolytic anemia (IMHA) in cats. In: Proceedings of the American College of Veterinary Internal Medicine; Dallas, USA; 2002.
-
Kohn B, Weingart C, Eckmann V, Ottenjann M, Leibold W. Primary immune-mediated hemolytic anemia in 19 cats: diagnosis, therapy and outcome (1998–2004). J Vet Intern Med. 2006; 20:159-166.
-
Kopke MA, Sarah P, Craig GR. Presumed immune-mediated haemolytic anaemia associated with pregnancy in a cat. J Feline Med Surg Open Rep. 2019; 5(1):1-5.
-
LeVine DN, Kidd L, Garden OA, et al. ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats. J Vet Intern Med. 2024; 38(4):1958-1981.
-
Limlenglert P, Rungsipipat A, Pusoonthornthum R. Application of flow cytometry for early diagnosis and monitoring in cats with immune-mediated hemolytic anemia. Thai J Vet Med. 2011; 41(2):185-191.
-
Johnston SA, Tobias KM. Veterinary Surgery: Small Animal, 2nd ed. Saunders; 2017.
-
McCullough S. Immune-mediated hemolytic anemia: understanding the nemesis. Vet Clin North Am Small Anim Pract. 2003; 33:1295-1315.
-
Paes G, Paepe D, Veldeman J, Campos M, Daminet S. Immune-mediated hemolytic anemia (IMHA) in cats-part 1: a review. Vlaams Diergeneeskd Tijdschr. 2010; 79:415-422.
-
Sentürk S, Temizel M. Treatment of immune-mediated hemolytic anemia and thrombocytopenia with vincristine in a dog. J Res Vet Med. 2001; 20:85-91.
-
Whitley N. Dealing with immune-mediated haematological diseases in dogs and cats: 2. Thrombocytopenia and Evan's syndrome. In Pract. 2020; 42(1):20-25.