Akut Civa Zehirlenmesi İle Başvuran Çocuklarda Biyokimyasal Parametreler Ve Lipoprotein ilişkili Fosfolipaz A2 (Lp-Pla2) Düzeyleri

Yıl 2011, Cilt: 5 Sayı: 3, 100 - 103, 26.12.2011

Ömer Yılmaz

Öz

Amaç: Çalışmada, akut civa toksisitesi saptanan çocuklarda biyokimyasal parametrelerin ve lipoprotein ilişkili fosfolipaz A2 düzeylerinin saptanması amaçlanmıştır.
Materyal ve Metod: Çalışmaya okul laboratuarında gerçekleşen bir kaza nedeniyle akut elemental civa maruziyeti oluşmuş 27 çocuk ve maruziyet hikayesi olmayan 24 sağlıklı kontrol dahil edilmiştir. ALT, AST, GGT, amilaz, üre, kreatinin, magnezyum, fosfor, kalsiyum düzeyi gibi biyokimyasal parametreler ve lipoprotein ilişkili fosfolipaz A2 seviyeleri saptanarak iki grup arasında fark olup olmadığı araştırılmıştır.

Bulgular: Yapılan istatistiksel analizlerde çalışılan parametreler açısından iki grup arasında farklılığa rastlanmamıştır.
Sonuç: Çalışılan parametrelerin civa zehirlenmesi olan çocuklarda akut dönemde etkilenmediği ve çalışma sonuçlarının örneklem zamanı ile ilişkili olduğu sonucuna varılmıştır.
Akut maruziyetin kronik dönemdeki etkilerinin monitörize edilmesi, farklı zamanlarda alınan örneklerde yapılacak ileri çalışmalarla aydınlığa kavuşabilecektir.

ABSRACT
Purpose: In our study, our aim is to detect the lipoprotein associated phospholipase A2 and biochemical parameters in children with acute mercury toxicity.
Material and Method: 27 children, who have been exposed to elemental mercury due to an accident in school laboratory and 24 healthy controls were included in the study. The difference between the two groups was investigated with analysis of biochemical parameters, including ALT, AST, GGT, amilase, urea, creatinine, magnesium, phosphorus, calcium and
lipoprotein associated phospholipase A2.

Findings: No difference between groups was demonstrated statistically.
Results: It has been concluded that; the analyzed parameters were not affected in acute period and results of analysis were related to the sampling time. Biomonitoring of chronic
effects of acute exposure needs further studies including periodical analysis of parameters in different sampling times

Anahtar Kelimeler

Civa toksisitesi, lipoprotein ilişkili fosfolipaz A2, karaciğer enzimleri, böbrek fonksiyonu, kalsiyum

Kaynakça

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