Botulinum-A Toxin Application for the Treatment of Asymmetric Crying Facies

Yıl 2010, Cilt: 17 Sayı: 4, 365 - 367, 01.08.2010

Mehmet Aslan Uğur Bıçak Ali Gürlek İsa Üzüm Cengiz Yakıncı

Öz

An infant with a face symmetrical at rest, but one corner of the mouth does not pull downward and outward symmetrically with the other while crying and smiling, is said to have an “asymmetric crying facies” (ACF). The etiology of this asymmetry is congenital absence or hypoplasia of the depressor anguli oris muscle (DAOM) at one corner of the mouth. Its associations with major congenital anomalies, most commonly in the cardiovascular system, have been reported. In this report, a six-year-old boy with asymmetric crying facies and its treatment with botulinum-A toxin (BOTOX) is presented. To our knowledge, the treatment of ACF with BOTOX has not been reported yet. Key words: Asymmetric Crying Facies; Botulinum-A Toxin; Child.

Anahtar Kelimeler

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Asimetrik Ağlayan Yüz Tedavisinde Botulinum-A Toksin Uygulaması

Öz

“Asimetrik ağlayan yüz” istirahat esnasında simetrik olan yüzün, ağlama ya da gülme sırasında ağız köşesinin aşağı ve dışa hareketinin kısıtlı olması ya da hiç olmamasıdır. Asimetrinin etiyolojisinde tek taraflı depresör anguli oris kasının konjenital yokluğu veya hipoplazisi vardır. Major konjenital anomalilerle, en çok da kardiovasküler sistemle birlikteliği bildirilmiştir. Bu yazıda asimetrik ağlayan yüzü olan 6 yaşındaki bir erkek çocuğu ve botulinum-A toksiniyle (BOTOKS) tedavisi sunulmaktadır. Asimetrik ağlayan yüzün BOTOKS'la tedavisi henüz bildirilmemiştir. Anahtar Sözcükler: Asimetrik Ağlayan Yüz; Botulinum-A Toksini; Çocuk.

Anahtar Kelimeler

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Kaynakça

• Pape KE, Pickering D. Asymmetric crying facies: an index of other congenital anomalies. J Pediatr 1972;81:22-30.
• Nelson KB, Eng GD. Congenital hypoplasia of the depressor anguli oris muscle: differentiation from congenital facial palsy. J Pediatr 1972;81:16-20.
• Bawle EV, Conard J, Van Dyke DL, et al. Seven new cases of Cayler cardiofacial syndrome with chromosome 22q11.2 deletion, including a familial case. Am J Med Genetics 1998;79:406-10.
• de Echaniz Espejo L, Narbona Garcia J, Garcia Corchon C, et al. Asymmetric crying facies syndrome. Ann Esp Pediatr 1987;27:199-204.
• Papadatos C, Alexiou D, Nicolopoulos D, et al. Congenital hypoplasia of depressor anguli oris muscle: a genetically determined condition? Arch Dis Child 1974;49:927-31.
• Meberg A, Skogen P. Three different manifestations of congenital muscular aplasia in a family. Acta Paediatr Scand 1987;76:375-77.
• D’Addio AP, Taiti S, Vitarelli A. A case of the cardiofacial syndrome (Cayler’s syndrome). Minerva Pediatr 1993;45:189-92.
• Innes AM. Asymmetric crying facies and associated congenital anomalies: the contribution of 22q11 microdeletions. J Child Neurol 2001;16:778.
• Hoefnagel D, Penry JK. Partial facial paralysis in young children. N Engl J Med 1960; 262:1126.
• Shaari CM, Wu B, Biller HF, et al. Botulinum toxin decreases salivation from canine submandibuler glands. Otolaryngol Head Neck Surg 1998;118:452-7.