Efficacy of multimodality approach to sudden hearing loss

Abstract

Objectives: This study aims to investigate whether addition of intratympanic steroid ITS to systemic steroid and hyperbaric oxygen HBO is effective in the treatment of sudden hearing loss SHL . Patients and Methods: Between January 2008 and October 2011, 58 patients diagnosed with SHL were enrolled in the study. Twenty patients 11 males, 9 females; mean age 45.3±21 years; range 24 to 66 years who received systemic steroid and HBO composed group 1, while 38 patients 19 males, 19 females; mean age 41.6±16 years; range 25 to 61 years who received ITS in addition to systemic steroid and HBO composed group 2. Results: Post-treatment hearing improvement was statistically significant in both groups in terms of the mean pure tone according to the Siegel’s criteria p<0.05 . Treatment was successful at 55% of patients in group 1 and 63% in group 2. Despite increased success rate with the addition of ITS, it did not indicate statistical significance p>0.05 . However, there was a strong statistically significant difference in terms of profound hearing loss over 90 dB p<0.05 . None of six patients 0% with profound hearing loss in group 1 benefited treatment, while addition of ITS to the treatment yielded success in six of 12 patients with profound hearing loss 50% in group 2 p<0.05 . Conclusion: Addition of ITS to systemic steroid and HBO treatment may yield better results in patients with SHL. However, ITS injection seems beneficial for patients with profound SHL.

Keywords

• Hyperbaric oxygen, intratympanic steroid, sudden sensorineural hearing loss

Ani işitme kaybında çoklu tedavi yaklaşımın etkinliği

Abstract

Amaç: Bu çalışmada ani işitme kaybının AİK tedavisinde sistemik steroid ve hiperbarik oksijene HBO ilave olarak intratimpanik steroidin ITS etkinliği araştırıldı.Hastalar ve Yöntemler: Ocak 2008 - Ekim 2011 tarihleri arasında AİK tanısı konulan 58 hasta çalışmaya dahil edildi. Sistemik steroid ve HBO tedavisi uygulanan 20 hasta 11 erkek, 9 kadın; ort. yaş 45.3±21 yıl; dağılım 24-66 yıl grup 1’i oluştururken; sistemik steroid ve HBO tedavisine ek olarak ITS tedavisi uygulanan 38 hasta 19 erkek, 19 kadın; ort. yaş 41.6±16 yıl; dağılım 25-61 yıl grup 2’yi oluşturdu.Bulgular: Tedavi sonrası iyileşme oranları, Siegel kriterlerine göre saf ses ortalamalarında her iki grup arasında istatistiksel olarak anlamlı bulundu p0.05 . Ancak 90 dB üzeri derin işitme kayıplarında güçlü bir istasitiksel fark vardı p

Keywords

• Hiperbarik oksijen, intratimpanik steroid, ani sensörinöral işitme kaybı

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