Öz

Solucan özleri, kanseri durdurucu ve önleyici çeşitli maddeler içermesi nedeniyle kanser araştırmalarında ilgi çekici bir araştırma alanı haline gelmiştir. Ekstraktın kanser hücreleri üzerindeki antikanser etkisinin belirlenmesi, kemoterapötik ajanların toksik etkilerine karşı yeni tedavi stratejilerine ve alternatif tıp yöntemlerine ilgiyi artırabilir. Bu nedenle bu çalışma, solucan ekstraktlarının doğasını ve kullanıldıkları kanser türlerini sistematik bir inceleme yoluyla vurgulayarak ilaç geliştirme ve gelecekteki antikanser tedavileri için farkındalık yaratmayı amaçlamaktadır. Ocak 2018 ile Aralık 2022 arasında yayınlanan makaleleri belirlemek için CINAHL, PubMed, Medline, Scopus ve Web of Science veritabanlarında sistematik bir arama yapıldı. 'Solucan', 'solucan özü' ve 'antikanser etkisi' anahtar kelimelerinin çeşitli düzenlemelerinden yararlandık. Solucan ekstraktlarının kanser hücreleri üzerindeki in vitro ve in vivo sitotoksik etkisini gösteren İngilizce yazılmış orijinal çalışmaları incelemeye dahil ettik. Arama kriterlerimizle eşleşen 15 çalışma bulduk. Yapılan çalışmalar arasında en çok çalışılan solucan türü Eisenia foetida (Savigny) olurken, en sık çalışılan kanser türü ise kolon kanseri oldu. Koleomik Sıvının antikanser aktivitesini pozitif sonuçlarla test etmek için yaygın olarak kullanılan ekstrakt olduğu bulundu.

A systematic review of antiproliferative and antitumour activity of earthworm extracts

Abstract

Earthworm extracts have become an interesting research area in cancer research due to their ingredients with anticancer and antiproliferative activities. Determining the anticancer effect of an extract on cancer cells may lead to new treatment strategies and alternative medicine to at least reduce the toxic effects of chemotherapeutic agents. In the present study, we aimed to raise awareness for drug development and future anticancer therapeutics by emphasizing the nature of earthworm extracts and the types of cancer they are used in through a systematic review. A systematic search of CINAHL, PubMed, Medline, Scopus and Web of Science databases was conducted to identify publications published between January 2018 and December 2022. We used different arrangements of the keywords ‘earthworm’, ‘earthworm extract’ and ‘anticancer effect’. We identified original studies written in English depicting in vitro and in vivo cytotoxic effects of earthworm extracts on cancer cells, and included these studies in our review. We found 15 studies matching our search criteria. Among the studies, Eisenia foetida (Savigny) was determined as the most studied earthworm, and colon cancer was the most frequently studied cancer type. The coleomic fluid was found to be the commonly used extract yielding positive results.

Keywords

• Anticancer effect
• Antiproliferative
• Cancer therapy
• Coleomic fluid
• Eisenia foetida
• Colon cancer

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